2. The ASU Animal Use Program A three-legged stool Institutional Official - Jon Harrison Institutional Official - Jon Harrison Institutional Animal Care & Use Committee Chair – Dale DeNardo Institutional Animal Care & Use Committee Chair – Dale DeNardo Attending Veterinarian (& DACT Director) - Joanne Tetens Attending Veterinarian (& DACT Director) - Joanne Tetens

3. Institutional Animal Care and Use Committee (IACUC) The IACUC provides internal oversight of animals used in research & teaching: - animal use procedures - husbandry - facilities The ASU IACUC consists of 11 voting members plus other supporting participants who include: - faculty representing the various departments and uses of animals - representatives of relevant ASU service units - DACT (including the Attending Vet) - Environmental Health & Safety - Campus Health - Risk Management - Office of Knowledge Enterprise Development Office - non-affiliated member

4. http://researchintegrity.asu.edu/animals/IACUC+Overview Institutional Animal Care and Use Committee (IACUC) Web site includes: - IACUC Policies and Procedures Manual - IACUC forms - protocol due dates & meeting dates - IACUC training instructions and exams - IACUC Standard Institutional Guidelines - AVMA euthanasia guidelines - professional society non-traditional species recommendations - federal regulations and other policies - Animal Welfare Assurance & USDA certificate numbers - Occupational Health & Safety Program documents - DACT forms & housing per diem rates - etc.

5. Primary objective - oversight To assure that ASU meets all regulatory requirements - USDA – enforces the Animal Welfare Act. Definition of “animal”? - OLAW (Office of Laboratory Animal Welfare) – oversees the use of non- human vertebrates in PHS-supported research or included in the institution’s PHS assurance (PHS Policy on Humane Care and Use of Laboratory Animals, 2002) - AAALACi (Association for the Assessment & Accreditation of Laboratory Animal Care International) – voluntary, covers all non-human vertebrates at the institution - U.S. Fish & Wildlife Service – oversees federally protected species, migratory birds, and international transport of all vertebrate animals and their parts - Arizona Game & Fish Department – oversees the capture & holding of native wildlife, as well as the holding of restricted non-native wildlife - Arizona Department of Health Services – covers species where there is a concern for zoonotic disease Institutional Animal Care and Use Committee (IACUC) Next tri-annual visit is this winter! All mammals except laboratory mice & rats

6. Institutional Animal Care and Use Committee (IACUC) Secondary objective - service To minimize the burden on investigators (provided it does not interfere with Objective 1) - Assist investigators in achieving compliance. - Develop processes that are consistent but flexible enough to be relevant to the varied animal use on campus. - Eliminate the need for duplication of effort by investigators (e.g., sharing of protocols across institutions)

7. Institutional Animal Care and Use Committee (IACUC) The review process (detailed in the Policies & Procedures Manual) : Protocols: - pre-reviewed by the Attending Veterinarian, then one other IACUC member (assigned by the Chair as the Primary Reviewer) - reviewed by the full committee at a convened meeting in the presence of the PI or designee Amendments: - Minor – administratively approved by the Chair - Significant – with the approval of the full committee, reviewed by a Designated Reviewer (assigned by the Chair) and the Attending Veterinarian - Major – reviewed by full committee at a convened meeting -the rationale for the new procedure is consistent with the research goals in the approved protocol -involves no increased risk of pain, distress, or discomfort to animals -does not markedly increase, by absolute or relative terms, the number of animals involved in the project - a change that does not affect the animals (e.g., adding personnel) - any change deemed substantive by the Chair or any IACUC member

8. Protocol Form - regulatory oversight is very dynamic (if the rules change, the form must change) - improve comprehension of the questions (the better the question, the more likely we get the info we need) - improve internal logistics (to ease reporting) Why does the protocol form change periodically? MAKE SURE TO USE THE MOST CURRENT FORM! (available on the web site)