Presentation on theme: "Chapter 16 Hemal Biochemistry The biochemistry and molecular biology department of CMU."— Presentation transcript:
Chapter 16 Hemal Biochemistry The biochemistry and molecular biology department of CMU
Composition of the blood –The liquid element: plasma –The formed elements: red blood cells (erythrocytes), white blood cells (leukocytes), and platelets (thrombocytes). Plasma --- The blood fraction obtained after removal of the cellular components. Serum --- The liquid element obtained by allowing the blood to clot.
Bilinogen enterohepatic circulation In the terminal ileum and large intestine, a small fraction of the urobilinogens is reabsorbed and reexcreted through the liver to constitute the enterohepatic cycle of urobilinogen.
4. Serum bilirubin and jaundice Conjugated bilirubin is also called direct reacting bilirubin or hepatobilirubin. ＊ Serum bilirubin 1 ～ 16 mol/l (0.1 ～ 1mg/dl) Free bilirubin is also called indirect reacting bilirubin or hemobilirubin.
free bilirubin conjugated bilirubin Binding with Glucuronic acid no yes Reacting with the diazo reagent Slow and indirect Rapid and direct solubility in watersmalllarge Discharged via kidneynoyes Pass through the membrane of cell yesno difference of two bilirubins
Laboratory results in patients with jaundice normal Hemolytic jaundice Hepatocellular jaundice Obstructive jaundice Serum bilirubin total < 1mg/dl > 1 > 1 > 1 direct 0~ 0.8mg/dl ↑ indirect < 1 Urine bile pigments urobilirubin ––+ urobilinogenA few ↑ uncertainty ↓ urobilinA few ↑ uncertainty ↓ Color of fecesnormaldark Simple or normal Clay color ↑ ↑ ↑