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Published byJoshua Malloy Modified over 10 years ago
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Class switch recombination Immunglobulin variable Region (Antigenbindung) konstante Region (Eigenschaften, Funktion)
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Class switch recombination DNA Ig heavy chain 53 EµIµ PSµCµCδCδIγ PSγSγCγCγIε PSεSεCεCεIα PSαSαCαCα3RR variabel konstant Eµ = Enhancer IP = Promotor für jeweilige konstante Region S = switch Region, repetitive Sequenz C = konstante Region Regionen µ, δ, γ3, γ1, γ2b, γ2a, ε, α 3RR= regulatorische Region downstream der C, 4 Enhancer VDJ
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Class switch recombination DNA Ig heavy chain 53 EµIµ PSµCµCδCδIγ PSγSγCγCγIε PSεSεCεCεIα PSαSαCαCα3RR 5 SµSαSαCαCα 3 loop VDJ Promotor aktiviert
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Class switch recombination DNA Ig heavy chain 53 EµIµ PSµCµCδCδIγ PSγSγCγCγIε PSεSεCεCεIα PSαSαCαCα3RR 5 SµSαSαCαCα 3 funktionsfähiges switch- Produkt mit Deletion hier: IgA switch circle VDJ
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