1. NIST: Promoting U.S. Innovation and Industrial Competitiveness Focus on Microfluidics Clara Asmail Technology Marketing Program Manager Technology Services National Institute of Standards and Technology U.S. Department of Commerce

2. NIST patented technologies to be presented tonight : Microfluidics portfolio  Simple High-Performance Biochemical Analysis  Methods For Polymer Microfluidic Fabrication  Microfluidic Mixing And Flow Manipulation  Uniform Assembly Of Nanoliposomes  Surface immobilization of biopolymers

3. What are Microfluidics? Precise control and manipulation of very small fluid flows ~ on the order of microliters or nanoliters ** a drop of water is approximately 25 microliters

4. Microfluidics conserves costs in biomedical research Small volume of fluids in microfluidic channels translates to: Small amounts of reagents and analytes used & Integrated process steps – simpler, faster

5. Industrial Applications for instrumentation suppliers Pharmaceutical & Biotech $600 B Diagnostics$30 B Medical Devices$200 B Drug Delivery $91 B (by 2009) $220 B (by 2015) Emerging Markets for Microfluidics Applications Geraldine Andrieux Gustin Yole Development June, 2007

6. Microfluidics: Market size expectations 2005 global market for microfluidic technologies ~ $2.9B by 2011 should grow to ~ $6.2 B i.e., an average annual growth rate of 14.1% Microfluidics Technology BCC Research September, 2006

7. Companies currently in Microfluidics market space: 3MCaliper LS Bartels mikrotechnikGyros Boehringer Ingelheim microPartsDiagnoswiss RainDance TechnologiesDyconex eGeneEksigent Technologies FluidigmGenesystems MicroplumbersNanogen IQ microWilden AG Weidmann PlasticsEpigem Micralyne Microfluidics chip shopMicronics Micronit microfluidicsWasatch microfluidics ThinXXSSpinX Technologies

8. Microfluidics: Critical market segments drug discovery drug delivery in-vitro diagnostics ink jet printing --- mature chemical analysis high-throughput screening

9. Microfluidics will enable efficient screening of more drugs in less time and drastically cut down the costs of drug development.

10. NIST technology presentations Dr. David Ross Simple High-Performance Biochemical Analysis Methods For Polymer Microfluidic Fabrication Microfluidic Mixing And Flow Manipulation Uniform Assembly Of Nanoliposomes Dr. Michael Tarlov Surface Immobilization Of Biopolymers