1. Scholarly Video Publishing to Increase Productivity and Standardization in Life Sciences Moshe Pritsker, Ph.D. CEO, Editor-in-Chief, co-founder, JoVE

2. Why we need academic video journals How to build a viable video journal Acceptance in the scientific community – current status

3. Scientific Article – same from 1665 First Issue of Philosophical Transactions of the Royal Society

4. Typical Scientific Article or Why Scientists Suffer Position the metaphase spindle at 3 o’clock and hold it with holding pipette. Apply piezo pulses to penetrate the zona pellucida. Touch the metaphase plate with the enucleation pipette. Aspirate the spindle and withdraw the pipette. What is this about???!!!

5. 1 picture vs. 1,000 words or why we need to publish in video Position the metaphase spindle at 3 o’clock and hold it with holding pipette. Apply piezo pulses to penetrate the zona pellucida. Touch the metaphase plate with the enucleation pipette. Aspirate the spindle and withdraw the pipette. Text article Real life

6. Solution: Visualized Description of Experimental Methods Text doesn’t work? Show it in video!

7. Structure of scientific video-articles 1. Animated Abstract 2. Introduction of scientists 3. Experimental procedure4. Discussion of results

8. New Article = Video + Text

9. Why scientists publish in JoVE - Journal, Not Database - Indexed in PubMed and Medline - Prestigous Editorial Board - Make your research reproducible - Show what you know to do to your colleagues - Spend less time on training - Retain technology in your lab when experts leave

10. JoVE - Current Status - Published 40 montly issues, >650 video-articles - 50 video-articles per month are produced across the world - Areas covered: Neuroscience, Immunology, Developmental Biology, Cell Biology, Biochemistry, Bioengineering, Plant Biology, Psychology, Medicine and others - First-and-only video journal accepted for indexing in PubMed and Medline - Most contributions from leading research universities in US and abroad: Harvard, MIT, Yale, NIH, Oxford, Cambridge, Max Planck, Weizmann Institute.... - Partnerships with traditional publishers: Science (AAAS), Current Protocols (Wiley), Springer Protocols (Springer) and Annual Reviews - Numerous articles in general and scientific press, TV and radio interviews (CNN, Nature, Science, WIRED, Voice of America, El Tiempo,....)

11. Starting from Prestigious Institutions

12. Who publishes what in JoVE? - Group of Eric Lander (MIT, Broad Instittue) - genomics: Hi-C: A Method to Study the Three-dimensional Architecture of Genomes - Group of Rudolf Jaenisch (MIT) – stem cells: Generating iPS Cells from MEFS through Forced Expression of Sox-2, Oct-4, c-Myc, and Klf4 - Group of Arturo Alvarez-Buylla (UCSF) – neural development: The Subventricular Zone En-face: Wholemount Staining and Ependymal Flow - Group of John Cooke (Stanford) – animal model of disease: Murine Model of Hindlimb Ischemia - Group of John Carlson (Yale) – behavior: Proboscis Extension Response (PER) Assay in Drosophila

13. Usage 2008 2007 2009 2008 2007 2009 80,000 visitors per months 210,000 downloads (3 pageloads per each visitor)

14. Who watches JoVE Per video 15,000 visitors / year 80% are from academia Top viewing countries include United States Western European countries China Canada Japan India

15. Institutions subscribed - 2010 >150 libraries subscribed: Harvard University, Massachusetts Institute of Technology – MIT, Brandeis University, Brown University, Cold Spring Harbor Laboratory – CSHL, Cornell University, Fred Hutchinson Cancer Research Center, George Mason University, Kent State University, Max-Planck-Institute for Medical Research (Germany), Mount Sinai School of Medicine – MSSM, National Institute of Health – NIH, National Taiwan University (Taiwan), Northeastern University of Illinois, Princeton University, Purdue University, Rockefeller University, Salk Institute, UC Davis, UC Irvine, UCLA, University of Verona (Italy), University of Hong Kong (Hong Kong), University of Iowa, University of Miami, University of New South Wales (Australia), University of Southern California – USC, University of Waterloo (Canada), University of Zurich (Switzerland), Vanderbilt University, Weizmann Institute of Science (Israel), Wellesley College, Yale University, Yonsei University (Korea),…

16. Testimonials Super idea. Excellent movie. Best wishes with your novel publishing concept. Thomas D. Pollard, PhD Professor, Yale University I just viewed an excellent little article on your site, and I would like to include it in the reference materials for my course. Moses Goddard, MD Associate Professor of Surgery, Brown University It is a great way of sharing the kinds of details that make all the difference but are very hard to put into a printed report. Helmut Hirsch, PhD, Distinguished Teaching Professor, University at Albany Thank you for creating and developing such an astounding resource for scientists! This is truly going to rapidly advance progress in all fields of research and the potential applications are endless. Lalitha Chandrasekher, Candidate for PhD Physiology and Biophysics, Georgetown Univ.

17. We film your video for you

18. Video production process Text Protocol Filming (5h) Editing Published

19. Videographer Network to Cover All Universities Covers USA, UK, Canada, Germany, Netherlands, Austria, Switzerland, Sweden, Denmark, Israel, Japan and Australia - Cost-effective platform for large-scale production of scientific videos from all over the world

20. Film at Your Lab I just wanted to say thank you for all of your professionalism and hard work with our team today. You and the team you assembled did a great job with the whole process (many faculty who saw us have commented positively) and you were able to still tolerate my less than stellar acting. Thanks again and I look forward to working with you all in the future. Glenn Glenn Raup PhD, RN, NE-BC Assistant Professor Harris College of Nursing & Health Sciences Texas Christian University

21. JoVE – what‘s next? JoVE Medicine JoVE Neuroscience JoVE Immunology ….

22. Your choice – what do you want for your users?

23. ROI for institutions Increase efficiency of learning for scientists and students Video journal: effective resource on how to do experiements Save money on research and education How much money saved? 1 post-doc: salary $50K per year, 6 month of work saved = $25K saved $25K x 10 = $250K

24. JoVE Team

25. Testimonial I recently had the opportunity to publish in the Journal of Visualized Experiments (JoVE), the online video journal for biological sciences. I came across JOVE when I was trying to understand the methodology of chromatin immunopreciptation assays. The text is accompanied by video demonstrations which makes the methodology of the experiments much more clear. Thus, JOVE is a very unique and useful resource for researchers, graduate students, postdocs and undergraduates in science. This novel visualization approach will improve reproducibility of experimental studies, and increase the efficiency of research and education in the biological sciences. Dr. John Cooke Professor of Medicine, Associate Director, Stanford Cardiovascular Institute.