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Syndemics Prevention Network

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Presentation on theme: "Syndemics Prevention Network"— Presentation transcript:

1 Syndemics Prevention Network
System Dynamics Simulation in Support of Obesity Prevention Decision-Making Bobby Milstein and Jack Homer For Institute of Medicine Committee on an Evidence Framework for Obesity Prevention Decision-Making Irvine, California March 16, 2009 Bobby Milstein (August 26, 2004)

2 Syndemics Prevention Network
Agenda System Dynamics Background Obesity Life-Course Model ( , CDC) Cardiovascular Risk Model ( , CDC & NIH) Bobby Milstein (August 26, 2004)

3 Syndemics Prevention Network
Re-Directing the Course of Change Questions Addressed by System Dynamics Modeling What? Prevalence of Obese Adults, United States Where? Historical Data Regression Forecast Simulation Experiments Why? How? Who? Regression Model Assumes Linear growth (by age, sex) Historical Data: NHANES Projection: Ruhm CJ. Current and future prevalence of obesity and severe obesity in the United States Forum for Health Economics & Policy 2007;10(2):1-28. Bobby Milstein (August 26, 2004)

4 Types of Models for Policy Planning & Evaluation
Syndemics Prevention Network Types of Models for Policy Planning & Evaluation Events Time Series Models Describe trends Increasing: Depth of causal theory Robustness for longer-term projection Value for developing policy insights Degrees of uncertainty Leverage for change Multivariate Statistical Models Identify historical trend drivers and correlates Patterns Dynamic Simulation Models Anticipate new trends, learn about policy consequences, and set justifiable goals Structure Bobby Milstein (August 26, 2004)

5 Syndemics Prevention Network
System Dynamics Simulating Dynamic Complexity Origins Jay Forrester, MIT, Industrial Dynamics, 1961 (“One of the seminal books of the last 20 years.”-- NY Times) Public policy applications starting late 1960s Population health applications starting mid-1970s Good at Capturing Differences between short- and long-term consequences of an action Time delays (e.g., incubation period, time to detect, time to respond) Accumulations (e.g., prevalences, resources, attitudes) Behavioral feedback (reactions by various actors) Nonlinear causal relationships (e.g., threshold effects, saturation effects) Differences or inconsistencies in goals/values among stakeholders Forrester JW. Industrial Dynamics. Cambridge, MA: MIT Press; 1961. Sterman JD. Business Dynamics: Systems Thinking and Modeling for a Complex World. Boston, MA: Irwin/McGraw-Hill; 2000. Bobby Milstein (August 26, 2004)

6 System Dynamics Health Applications 1970s to the Present
Syndemics Prevention Network System Dynamics Health Applications 1970s to the Present Disease epidemiology Cardiovascular, diabetes, obesity, HIV/AIDS, cervical cancer, chlamydia, dengue fever, drug-resistant infections Substance abuse epidemiology Heroin, cocaine, tobacco Health care patient flows Acute care, long-term care Health care capacity and delivery Managed care, dental care, mental health care, disaster preparedness, community health programs Health system economics Interactions of providers, payers, patients, and investors Homer J, Hirsch G. System dynamics modeling for public health: Background and opportunities. American Journal of Public Health 2006;96(3): Bobby Milstein (August 26, 2004)

7 An (Inter) Active Form of Policy Planning/Evaluation
Syndemics Prevention Network An (Inter) Active Form of Policy Planning/Evaluation System Dynamics is a methodology to… Map the salient forces that contribute to a persistent problem; Convert the map into a computer simulation model, integrating the best information and insight available; Compare results from simulated “What If…” experiments to identify intervention policies that might plausibly alleviate the problem; Conduct sensitivity analyses to assess areas of uncertainty in the model and guide future research; Convene diverse stakeholders to participate in model-supported “Action Labs,” which allow participants to discover for themselves the likely consequences of alternative policy scenarios Realistic understanding of causal dynamics (actions, reactions, accumulations, delays) Justifiable goals (numerical targets, life-course implications, timing) Criteria for choosing actions and impetus for implementing them (within the health sector and beyond) Bobby Milstein (August 26, 2004)

8 Syndemics Prevention Network
An Ecological Framework for Organizing Influences on Overweight and Obesity Energy Balance Prevention of Overweight and Obesity Among Children, Adolescents, and Adults Individual Factors Behavioral Settings Social Norms and Values Home and Family School Community Work Site Healthcare Genetics Psychosocial Other Personal Factors Food and Beverage Industry Agriculture Education Media Government Public Health Systems Healthcare Industry Business and Workers Land Use and Transportation Leisure and Recreation Food and Beverage Intake Physical Activity Sectors of Influence Energy Intake Energy Expenditure Adapted from: Koplan JP, Liverman CT, Kraak VI, editors. Preventing childhood obesity: health in the balance. Washington, DC: Institute of Medicine, National Academies Press; 2005. Bobby Milstein (August 26, 2004)

9 The Obesity “System”: A Broad Causal Map
Syndemics Prevention Network The Obesity “System”: A Broad Causal Map Responses to Growth B1 Self-improvement B2 Medical response B3 Improving preventive healthcare B4 Creating better messages B5 Creating better options in beh. settings B6 Creating better conditions in wider environ B7 Addressing related health conditions Engines of Growth R1 Spiral of poor health and habits R2 Parents and peer transmission R3 Media mirrors R4 Options shape habits shape options R5 Society shapes options shape society Resources, Resistance, Benefits & Supports R6 Disease care costs squeeze prevention B8 Up-front costs undercut protection efforts B9 Defending the status quo B10 Potential savings build support R7 Broader benefits build support 5/8/05 Bobby Milstein (August 26, 2004)

10 The Closed-Loop View Leads Us To Question…
Syndemics Prevention Network The Closed-Loop View Leads Us To Question… How can the engines of growth loops (i.e. social and economic reinforcements) be weakened? What incentives can reward parents, school administrators, employers, and other decision-makers for expanding healthy diet and activity options ? Are there resources for health protection that do not compete with disease care? How can industries be motivated to change the status quo rather than defend it? How can benefits beyond weight reduction be used to stimulate investments in expanding healthier options? Bobby Milstein (August 26, 2004)

11 Syndemics Prevention Network
Mapping and Modeling Two systems thinking tools: Causal loop diagramming (mapping) Mathematical simulation (modeling) Causal diagrams provide a ‘macroscopic’ view that goes beyond ‘laundry list’ thinking by introducing circular causality. Maps reveal possibilities, but are not testable. They have little explanatory power and cannot weigh the relative importance of factors. A useful evidence-based systems framework includes both maps and models. “Without modeling, we might think we are learning to think holistically when we are actually learning to jump to conclusions.” – John Sterman Hurricane Andrew: Aug, 23, 24, 25, 1992 Homer J and Oliva R. Maps and models in system dynamics: a response to Coyle System Dynamics Review 2001; 17: Bobby Milstein (August 26, 2004)

12 Simulation and “Double-Loop Learning”
Syndemics Prevention Network Simulation and “Double-Loop Learning” Real World Unknown structure Dynamic complexity Time delays Impossible experiments Virtual World Known structure Controlled experiments Enhanced learning Implementation Game playing Inconsistency Short term Selected Missing Delayed Biased Ambiguous Decisions Information Feedback Strategy, Structure, Decision Rules Inability to infer dynamics from mental models Mental Models Misperceptions Unscientific Biases Defensiveness Sterman JD. Learning in and about complex systems. System Dynamics Review 1994;10(2-3): Sterman JD. Business dynamics: systems thinking and modeling for a complex world. Boston, MA: Irwin McGraw-Hill, 2000. Bobby Milstein (August 26, 2004)

13 What is a System? What are Dynamics?
Syndemics Prevention Network What is a System? What are Dynamics? System (Structure) = Stocks + Flows + Feedback Loops +… Stocks are accumulations of flows (of population, resources, changing goals, perceptions, etc.) Feedback loops link accumulations back to decisions that alter the flows: only 2 types (goal-seeking, self-reinforcing) Delays complicate things further As do non-linearities (need for critical mass, saturation effects) Dynamics = Behavior over time Patterns in time series data (growth, fluctuation, etc.) Visible relationships of two or more variables (move together, move opposite, lead-lag, etc.) Bobby Milstein (August 26, 2004)

14 Syndemics Prevention Network
System Dynamics Moves from Behavior to Structure by Identifying Accumulations and Feedback Responses Problem Situation 8 6 4 2 10 12 14 16 18 20 Seconds elapsed Ounces Water Level Over Time System Behavior System Structure Bobby Milstein (August 26, 2004)

15 Water Glass Model Diagram (Vensim™ software)
Syndemics Prevention Network Water Glass Model Diagram (Vensim™ software) Faucet openness Water flow at full open Maximum faucet openness decision “Policy Lever” Current Water Level Water flow “Stock” “Flow” “Constant” Desired water level Water level gap “Delay” Perceived water level gap Time to perceive water level gap Bobby Milstein (August 26, 2004)

16 Complete Equations for Water Glass Model
Syndemics Prevention Network Bobby Milstein (August 26, 2004)

17 Sample Output from Water Glass Model
Syndemics Prevention Network Sample Output from Water Glass Model What If… 8 Ounces Perc time Max open Target 6 4 2 2 4 6 8 10 12 14 16 18 20 Seconds elapsed Bobby Milstein (August 26, 2004)

18 Review: Basic Steps in SD Model Building
Syndemics Prevention Network Review: Basic Steps in SD Model Building Problem Situation 8 6 4 2 10 12 14 16 18 20 Seconds elapsed Ounces System Behavior Target System Structure What if…? Perc time Max open Water flow at full open 1. Current water level = INTEG( Water flow , 0) 2. Water flow = Water flow at full open * Faucet openness 3. Water flow at full open = 1 ounce per second 4. Faucet openness = MAX (0, MIN (Maximum faucet openness decision, Perceived water level gap / Water flow at full open )) 5. Maximum faucet openness decision = 1 out of possible 1 6. Perceived water level gap = DELAY1I (Water level gap, Time to perceive water level gap, 0) 7. Water level gap = Desired water level - Current water level 8. Desired water level = 6 ounces 9. Time to perceive water level gap = 1 second FINAL TIME = 20 seconds INITIAL TIME = 0 TIME STEP = seconds System Equations System Model Current water level Water flow Desired water level Water level gap Faucet openness Perceived water level gap Time to perceive water level gap Maximum faucet openness decision Bobby Milstein (August 26, 2004)

19 The Modeling Process is Iterative…
Syndemics Prevention Network The Modeling Process is Iterative… Adapted from Saeed 1992 Homer JB. Why we iterate: scientific modeling in theory and practice. System Dynamics Review 1996;12(1):1-19. Bobby Milstein (August 26, 2004)

20 Empirical…and…Critical
Syndemics Prevention Network Empirical…and…Critical Forrester JW, Senge PM. Tests for building confidence in system dynamics models. In: Legasto A, Forrester JW, Lyneis JM, editors. System Dynamics. New York, NY: North-Holland; p Graham AK. Parameter estimation in system dynamics modeling. In: Randers J, editor. Elements of the System Dynamics Method. Cambridge, MA: MIT Press; p Sterman JD. Business dynamics: systems thinking and modeling for a complex world. Boston, MA: Irwin McGraw-Hill, 2000. Bobby Milstein (August 26, 2004)

21 Practical Options in Causal Modeling
Syndemics Prevention Network Practical Options in Causal Modeling High Impractical Expansive Too hard to verify, modify, and understand Scope (Breadth) Focused Simplistic Low Low High Detail (Disaggregation) Bobby Milstein (August 26, 2004)

22 Syndemics Prevention Network
Model Structure and Level of Detail Depends on the Intended Uses and Audiences Set Better Goals (Planners & Evaluators) Identify what is likely and what is possible Estimate intervention impact time profiles Evaluate resource needs for meeting goals Support Better Action (Policymakers) Explore ways of combining policies for better results Evaluate cost-effectiveness over extended time periods Increase policymakers’ motivation to act differently Develop Better Theory and Estimates (Researchers) Integrate and reconcile diverse data sources Identify causal mechanisms driving system behavior Improve estimates of hard-to-measure or “hidden” variables Identify key uncertainties to address in intervention studies Forrester JW. Industrial Dynamics (Chapter 11: Aggregation of Variables). Cambridge, MA: MIT Press, 1961. Bobby Milstein (August 26, 2004)

23 Tests for Building Confidence in Simulation Models
Syndemics Prevention Network Tests for Building Confidence in Simulation Models Focusing on STRUCTURE Focusing on BEHAVIOR ROBUSTNESS Dimensional consistency Extreme conditions Boundary adequacy Parameter (in)sensitivity Structure (in)sensitivity REALISM Face validity Parameter values Replication of behavior Surprise behavior Statistical tests UTILITY Appropriateness for audience and purposes Counterintuitive behavior Generation of insights Forrester 1973, Forrester & Senge 1980, Richardson and Pugh 1981 Bobby Milstein (August 26, 2004)

24 The Future of Systems Simulation
Syndemics Prevention Network The Future of Systems Simulation More ambitious models, addressing big strategic questions Supporting macro-models with more empirical data, but also with the results of focused (operational, mechanistic) micro-models Improved use of expert judgment; e.g., Delphi method More use of software tools for automated model calibration, sensitivity testing, and documentation Better public outreach through logical, balanced presentation that provides clear path from evidence to insight “There seems to be a common attitude that the major difficulty is shortage of information and data. Once data are collected, people feel confident in interpreting the implications. I differ on both of these attitudes. The problem is not shortage of data but rather our inability to perceive the consequences of the information we already possess.” – Jay Forrester Forrester JW. System dynamics—the next fifty years. System Dynamics Review 2007;23(2/3): Homer JB. Macro- and micro-modeling of field service dynamics. System Dynamics Review 1999;15(2): Meadows DH, Robinson JM. The Electronic Oracle: Computer Models and Social Decisions. Wiley & Sons, 1985. Bobby Milstein (August 26, 2004)

25 Obesity Life-Course Model (with CDC, 2005-2006)
Syndemics Prevention Network Obesity Life-Course Model (with CDC, ) Initially considered obesity dynamics broadly Narrowed our focus to address a fundamental question at the heart of much policy discussion: How do changes in caloric balance affect the future BMI distribution across the life-course? What does that imply for policy? Growth of Obesity for Four Age Ranges United States, Obesity definitions by age Ages 2-19: BMI>=30 or >=95th percentile on CDC growth chart Ages 20-74: BMI>=30 Data source: National Center for Health Statistics, CDC: National Health Examination Survey (NHES) , National Health and Nutrition Examination Survey (NHANES) Homer J, Milstein B, Dietz W, et al. Obesity population dynamics: exploring historical growth and plausible futures in the U.S. Proc. 24th Int’l System Dynamics Conference; Nijmegen, The Netherlands; July 2006. Bobby Milstein (August 26, 2004)

26 Focusing on Life-Course Dynamics
Syndemics Prevention Network Focusing on Life-Course Dynamics Explore likely consequences of possible interventions affecting caloric balance (intake less expenditure) How much impact on obesity prevalence? How long will it take to see? Should we target particular subpopulations? (age, sex, weight category; lack data for race, ethnicity) Consider interventions broadly but leave details (composition, coverage, efficacy, cost) outside model boundary for now Available data inadequate Would require a separate research effort to estimate these details Not addressing feedback loops of reinforcement and resistance Not addressing cost-effectiveness Bobby Milstein (August 26, 2004)

27 Syndemics Prevention Network
Growth of Obesity by Age Range since (Gender breakout not shown here) Syndemics Prevention Network Definitions Ages 2-19 (NHES): Overweight BMI>=85th percentile, Obese BMI>=95th percentile on CDC growth chart Ages 2-19 (NHANES): Overweight BMI>=25 or 85th percentile, Obese BMI>=30 or 95th percentile, Severely obese BMI>=35 or 99th percentile on CDC growth chart Ages 20-74: Overweight BMI>=25; Obese BMI>=30; Severely obese BMI>=35 Bobby Milstein (August 26, 2004)

28 Syndemics Prevention Network
Population Weight-Change Dynamics From Caloric Balance to Obesity Prevalence Dynamic Population Weight Framework Birth Immigration Yearly aging Population by Age (0-99) and Sex Caloric Flow-rates between Not Moderately Moderately Severely Balance BMI categories Overweight Overweight Obese Obese Death Overweight and obesity prevalence Data sources: NHANES, CDC growth charts, Census, Vital Statistics, Arkansas K-12 assessment, Forbes 1986, Flegal 2005 Bobby Milstein (August 26, 2004)

29 Detail of Aging and BMI Change Processes
Syndemics Prevention Network Detail of Aging and BMI Change Processes Not Overweight Moderately Obese Severely Births Age 0 Age 1 Age 99 No Change in BMI Category (maintenance flow) Increase in BMI Category (up-flow) Decline in BMI Category (down-flow) Data sources: NHANES, CDC growth charts, Census, Vital Statistics, Arkansas K-12 assessment, Forbes 1986, Flegal 2005 Bobby Milstein (August 26, 2004)

30 Two Classes of Interventions
Syndemics Prevention Network Two Classes of Interventions Dynamic Population Weight Framework Birth Immigration Yearly aging Changes in the Physical Population by Age (0-99) and Sex and Social Environment Trends and Planned Caloric Flow-rates between Not Moderately Moderately Severely Interventions Balance BMI categories Overweight Overweight Obese Obese Weight Loss/Maintenance Services for Individuals Death Overweight and obesity prevalence Data sources: NHANES, CDC growth charts, Census, Vital Statistics, Arkansas K-12 assessment, Forbes 1986, Flegal 2005 Bobby Milstein (August 26, 2004)

31 Syndemics Prevention Network
Is Adult Activity and Eating Much Influenced by Habits Learned in Childhood? It is often said that activity and eating habits are shaped during early childhood, and that once poor habits are established, it is difficult to change them.1 It is true that overweight children are more likely to become obese adults.2 However, this could simply reflect adult surroundings that are in many cases similar to the childhood environment. Adequate long-term studies to test the habit-carryover hypothesis have not been done.3 What happens when the childhood environment was healthy but the adult environment is not, or vice versa? We don’t know. But we do know there is a strong link between one’s current surroundings and social networks and one’s weight.4 1. Ritchie et al. Pediatric overweight: A review of the literature. UC Berkeley Center for Weight and Health, 2001; Byrne, J Nutrition Education and Behavior, 34(4), 2002. 2. Deckelbaum and Williams, Obesity Research 9(Suppl 4), 2001; Dietz and Gortmaker, Annual Review of Public Health 22, 2001; Goran MI, AJCN 73, 2001; Dietz WH, J Nutrition128(S), 1998. 3. Bar-Or O., PCPFS Research Digest Series 2, No. 4, 1995. 4. Christakis and Fowler. NEJM 357, 2007. Bobby Milstein (August 26, 2004)

32 Syndemics Prevention Network
Findings An inflection point in the growth of overweight and obesity prevalences probably occurred during the 1990s The daily caloric imbalance accounting for this growth has been less than 50 kcal/day (within each BMI category) Impacts of changing environments on adult obesity take decades to play out fully: “Carryover effect” Youth interventions have only small impact on overall adult obesity (assuming adult habits are determined by adult environment) Weight loss programs for the obese could accelerate progress—but is there a realistic alternative to risky/expensive bariatric surgery? Bobby Milstein (August 26, 2004)

33 Alternative Futures for Teenage Obesity
Syndemics Prevention Network Alternative Futures for Teenage Obesity Obese fraction of Teens (Ages 12-19) 50% 40% 30% Fraction of popn 12-19 20% 10% 0% 1970 1980 1990 2000 2010 2020 2030 2040 2050 Base SchoolYouth AllYouth AllAges+WtLoss Bobby Milstein (August 26, 2004)

34 Alternative Futures for Adult Obesity
Syndemics Prevention Network Alternative Futures for Adult Obesity Obese fraction of Adults (Ages 20-74) 50% 40% 30% Fraction of popn 20-74 20% 10% 0% 1970 1980 1990 2000 2010 2020 2030 2040 2050 Base SchoolYouth AllYouth School+Parents AllAdults AllAges AllAges+WtLoss Bobby Milstein (August 26, 2004)

35 Possible Extensions to Model Details of Activity & Food Environments
Dynamic Population Weight Framework Population by Age (0-99) and Sex Flow-rates between BMI categories Overweight and obesity prevalence Obesity-attributable unhealthy days illness costs Birth Immigration Death Caloric Balance Yearly aging Not Overweight Moderately Obese Severely Trends and Planned Interventions Changes in the Physical and Social Environment Weight Loss/Maintenance Services for Individuals Food Price Smoking Social Influences on Consumption & Selection Options for Affordable Recommended Foods (Work, School, Markets, Restaurants) Activity Limiting Conditions Options for Safe, Accessible Physical Activity (Work, School, Neighborhoods) Distance from Home to Work, School, Errands Electronic Media in the Home Active/Inactive Options Activity Environment Food Syndemics Prevention Network Possible Extensions to Model Details of Activity & Food Environments Indicates possible extensions to the existing model Bobby Milstein (August 26, 2004)

36 Syndemics Prevention Network
Cardiovascular Disease Intervention Strategy (with CDC and NIH, ) What are the key pathways of CV risk, and how do these affect health outcomes and costs? How might interventions affect the risk factors and outcomes in the short- and long-term? How might policy efforts be better balanced given limited resources? The CDC has partnered on this project with the Austin (Travis County), Texas, Dept. of Health and Human Services. The model is calibrated to represent the overall US, but is informed by the experience and local data of the Austin team. Homer J, Milstein B, Wile K, Pratibhu P, Farris R, Orenstein D. Modeling the local dynamics of cardiovascular health: risk factors, context, and capacity. Preventing Chronic Disease 2008;5(2). Available at Homer J, Milstein B, Wile K, Trogdon J, Huang P, Labarthe D, Orenstein D. Simulating and evaluating local interventions to improve cardiovascular health. In submission to Preventing Chronic Disease. Bobby Milstein (August 26, 2004)

37 Syndemics Prevention Network
Risk Factors for CVD Data sources: NHANES, NHIS, MEPS, AHA/NIH reports, Census, Vital Statistics, Framingham risk calculators, literature on risk factors and costs Bobby Milstein (August 26, 2004)

38 Tobacco and Air Quality Interventions
Syndemics Prevention Network Tobacco and Air Quality Interventions Data sources: NHANES, NHIS, MEPS, AHA/NIH reports, Census, Vital Statistics, Framingham risk calculators, literature on risk factors and costs Bobby Milstein (August 26, 2004)

39 Health Care Interventions
Syndemics Prevention Network Health Care Interventions Data sources: NHANES, NHIS, MEPS, AHA/NIH reports, Census, Vital Statistics, Framingham risk calculators, literature on risk factors and costs Bobby Milstein (August 26, 2004)

40 Interventions Affecting Stress
Syndemics Prevention Network Interventions Affecting Stress Data sources: NHANES, NHIS, MEPS, AHA/NIH reports, Census, Vital Statistics, Framingham risk calculators, literature on risk factors and costs Bobby Milstein (August 26, 2004)

41 Healthy Diet Interventions
Syndemics Prevention Network Healthy Diet Interventions Data sources: NHANES, NHIS, MEPS, AHA/NIH reports, Census, Vital Statistics, Framingham risk calculators, literature on risk factors and costs Bobby Milstein (August 26, 2004)

42 Physical Activity & Weight Loss Interventions
Syndemics Prevention Network Physical Activity & Weight Loss Interventions Data sources: NHANES, NHIS, MEPS, AHA/NIH reports, Census, Vital Statistics, Framingham risk calculators, literature on risk factors and costs Bobby Milstein (August 26, 2004)

43 Syndemics Prevention Network
Adding Up the Costs Data sources: NHANES, NHIS, MEPS, AHA/NIH reports, Census, Vital Statistics, Framingham risk calculators, literature on risk factors and costs Bobby Milstein (August 26, 2004)

44 Syndemics Prevention Network
Graphs of assumptions #1: Age 18 obesity reduced 70% by 2030 #2a: Poor diet reduced from 64% to 41% #3: Use of weight loss services among obese increased from 10% to 24% #2b: Inadequate PA reduced from 51% to 22% Bobby Milstein (August 26, 2004)

45 Obesity prevalence in adults (all subgroups combined)
Syndemics Prevention Network Obesity prevalence in adults (all subgroups combined) -3.5% -30.5% -37.2% As in the life-course model, lower childhood obesity accounts for only 12% of the adult prevalence reduction projected in the full-population approach of “Teen_DietPA” Bobby Milstein (August 26, 2004)

46 Syndemics Prevention Network
Further Consequences With the three policies combined, cumulative deaths through 2040 can be reduced by 2.36M and cumulative consequence costs by $1.08Tr Bobby Milstein (August 26, 2004)


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