Presentation is loading. Please wait.

Presentation is loading. Please wait.

Figure 1 Regulation of systemic functions by signaling through G protein pathways. S R Neves et al. Science 2002;296:1636-1639 Published by AAAS.

Similar presentations


Presentation on theme: "Figure 1 Regulation of systemic functions by signaling through G protein pathways. S R Neves et al. Science 2002;296:1636-1639 Published by AAAS."— Presentation transcript:

1 Figure 1 Regulation of systemic functions by signaling through G protein pathways. S R Neves et al. Science 2002;296:1636-1639 Published by AAAS

2

3

4 Backpropagation of action potentials (APs) in different morphologies with identical channel types and distributions Philipp Vetter, Arnd Roth and Michael Häusser J Neurophysiol 85:926-937, 2001.

5 Sensitivity of backpropagation to voltage- gated channel density in different cell types

6 Morphological determinants of backpropagation. A: relationship between the number of dendritic branchpoints and gNa,thresh B: rate of increase in membrane area withdistance from the soma (dA/dx) C: relationship between the maximum slope of the smoothed dA/dx distribution and gNa,thresh

7 Forward propagation depends on dendritic geometry. A–C: forward propagation of a dendritic AP was simulated successively at all dendritic locations in a nigral dopamine neuron (A), a layer 5 pyramidal cell (B), and a cerebellar Purkinje neuron (C)

8 Dendritic Plateau Potentials X. Cai, C.W. Liang, S. Muralidharan, J.P. Kao, C.M. Tang and S.M. Thompson Neuron 44 (2004), pp. 351–364

9 Block of SK Channels in Distal Dendrites Facilitates the Triggering of Action Potential with Dendritic Glutamate Application

10

11 Apamin-Sensitive Ca2-Activated K Channels in the Distal Dendrites Are Responsible for Repolarization of Plateau Potentials

12 Nickel-sensitive T-type and apamin-sensitive SK channels maintained the high precision of pacemaker spiking in dopaminergic neurons. Wolfart J, Roeper J J. Neurosci. 2002;22:3404-3413

13 Inhibition of T-type channels evoked bursting in a subpopulation of dopaminergic midbrain neurons.

14 Focal activation of mGluRs induces a wave of Ca 2+ Morikawa HMorikawa H, Khodakhah K, Williams JT J Neurosci. 2003 Jan 1;23(1):149-57K, Williamsi. 2003 Jan

15 Simultaneous blockade of IP3- and cADPR-induced signaling inhibits mGluR IPSCs. A, Intracellular dialysis of both heparin (1 mg/ml) and 8-NH2-cADPR (50 μm) nearly abolished mGluR IPSCs. The cell was first recorded with a control internal solution to obtain a control IPSC amplitude (IPSC1) at ∼ 10 min after the onset of recording. Morikawa H et al. J. Neurosci. 2003;23:149-157

16 Proposed intracellular signaling cascade mediating the mGluR-induced Ca2+ mobilization. Morikawa H et al. J. Neurosci. 2003;23:149-157

17 Block of SK channels increases the firing rate of Purkinje neurons. Womack M D, Khodakhah K J. Neurosci. 2003;23:2600-2607

18 SK channels affect the action potential afterhyperpolarization in Purkinje neurons. Womack M D, Khodakhah K J. Neurosci. 2003;23:2600-2607

19 Block of SK channels increases the firing rate but maintains the trimodal pattern in cells that have the trimodal pattern of activity. Womack M D, Khodakhah K J. Neurosci. 2003;23:2600-2607


Download ppt "Figure 1 Regulation of systemic functions by signaling through G protein pathways. S R Neves et al. Science 2002;296:1636-1639 Published by AAAS."

Similar presentations


Ads by Google