1. Thursday, October 2, 2014 Title: Genetic Disorders LT: I will be able to explain the inheritance of various genetic disorders. Do Now: 1.What is the difference between an autosomal disorder and a sex linked disorder? 2.Analyze the pedigree below and answer the following: The characteristic indicated by the blackened figures is probably: a. Dominant. b. Recessive. c. Non-dominant. d. Sex-linked recessive.

2. Pedigree Question #1 to Ask… What is the mode of inheritance? –Autosomal dominant: the disorder is a dominant trait, only one affected allele must be inherited to show the phenotype –Autosomal recessive: the disorder is a recessive trait and offspring must inherit TWO recessive alleles to show the phenotype –Sex Linked: the disorder is LINKED to the X chromosome and is inherited when the affected X or two affected X chromosomes are passed on

3. How do I Know??? Autosomal DOMINANT

4. Autosomal Dominant Disorders: Affects males and females equally Both genders can pass the trait Later generations will be affected Rarely skips a generation –Achondroplasia (dwarfism) –Huntington’s Disease –Marfan Disease

5. How do I Know??? Sex Linked Disorder

6. Sex Linked Disorders Affects males more than females Only females can be carriers Can be passed from either parent* Most are recessive –Duchenne Muscular Dystrophy –Colorblindness –Hemophilia

7. How do I Know??? Autosomal RECESSIVE

8. Autosomal Recessive Disorders Affects both genders equally Can skip generations Both genders can be carriers –Cystic Fibrosis –Sickle Cell Anemia –Tay-Sachs

9. Today’s Activity: You and a partner will research ONE inherited genetic disorder. You will use that research to identify FIVE FAST FACTS about the disorder. You will then read a scenario about a family that has a history of that disorder. Using the scenario, you will create a pedigree that accurately represents the family history of that disorder. You will then answer the questions posed. Your final assessment of mastery will be a POSTER and PRESENTATION* of that poster to the class.

10. Poster Requirements: Disorder Name: BOLD, NEAT, CLEAR Five Facts Pedigree: CORRECT, CLEAR, NEAT @ least ONE Punnett Square you ran Scenario attached *My walls are bare… I’d like to change that!

11. Thursday, October 2, 2014 Title: Pedigrees and Genetic Disorders LT: I will be able to trace the inheritance of a trait within a family. Do Now: Why would it be important to be able to track the inheritance of a trait across multiple generations of a family?

12. Today’s Agenda 1.You will record live notes about PEDIGREES and GENETIC DISORDERS. 2.You will receive a practice worksheet about pedigrees to complete as homework, DUE tomorrow.

13. Friday, October 3, 2014 Do Now: Using the pedigree, determine which mode of inheritance (autosomal dominant, autosomal recessive, sex linked) the trait follows. Explain your choice. Then, determine the genotype of person X. LT: I will be able to track the inheritance of a trait within multiple generations of a family using a pedigree.

14. Today’s Agenda 1.You will continue your genetic investigation of a family history and a genetic disorder. 2.DUE at END of class: 1.Completed poster 2.Don’t forget to turn in your purple pedigree homework!

15. Friday, October 3, 2014 Do Now: DRAW THE PEDIGREE! Using the pedigree, determine: –What is the relationship between U, V and W? –What is the phenotype of X? –What is the genotype of Y? Title: Pedigrees – Mode of Inheritance LT: I will be able to track the inheritance of a trait within multiple generations of a family using a pedigree.

16. Today’s Agenda 1.You will record quick notes about PEDIGREES and GENETIC DISORDERS. 2.You will work with your lab group to create a pedigree about a family and their history of a genetic disorder. 3.Don’t forget!!! Turn in your pedigree homework from last night!

17. Pedigree Question #1 to Ask… What is the mode of inheritance? –Autosomal dominant: the disorder is a dominant trait, only one affected allele must be inherited to show the phenotype –Autosomal recessive: the disorder is a recessive trait and offspring must inherit TWO recessive alleles to show the phenotype –Sex Linked: the disorder is LINKED to the X chromosome and is inherited when the affected X or two affected X chromosomes are passed on

18. How do I Know??? Autosomal DOMINANT

19. Autosomal Dominant Disorders: Affects males and females equally Both genders can pass the trait Later generations will be affected Rarely skips a generation –Achondroplasia (dwarfism) –Huntington’s Disease –Marfan Disease

20. How do I Know??? Sex Linked Disorder

21. Sex Linked Disorders Affects males more than females Only females can be carriers Can be passed from either parent* Most are recessive –Duchenne Muscular Dystrophy –Colorblindness –Hemophilia

22. How do I Know??? Autosomal RECESSIVE

23. Autosomal Recessive Disorders Affects both genders equally Can skip generations Both genders can be carriers –Cystic Fibrosis –Sickle Cell Anemia –Tay-Sachs