1. 2014 Summit Co-Convener:Founder: Patient Safety Science & Technology Summit 2014

2. 2014 Summit Co-Convener:Founder: Charles Dean Kurth, MD Anesthesiologist in Chief Director, Department of Anesthesiology Professor, UC Department of Anesthesiology

3. 2014 Summit Co-Convener:Founder: Neonatal Patient Safety Newborn Screening & Oxygen Targeting

4. 2014 Summit Co-Convener:Founder: Neonatal Mortality Rates per 1000 Live Births 19631990 1990 Rank among 197 countries2011 2011 Rank among 197 countries Japan13.831 st 1.21 st Australia19.5518 th 2.427 th US18.2629 th 3.945 th Infant, fetal and maternal mortality. United States-1963. Vital Health Stat 20. 1966 (3): 1-64. Straney LD, Lim SS, Murray CJL, et al. PLOS ONE 2012; 7: 11:e49399. Lozano R, Wang H, Foreman KJ, et al. Lancet 2011; 378: 1139-65. UN Interagency Group for Child Mortality Estimation. Levels and Trends in Child Mortality. UNICEF, WHO, World Bank, UN Population Division, 2012.

5. 2014 Summit Co-Convener:Founder: Significant Performance Gaps Failing to detect Critical Congenital Heart Disease (CCHD) Suboptimal neonatal oxygen targeting

6. 2014 Summit Co-Convener:Founder: Congenital Heart Defects (CHD) #1 Birth defect everywhere 100,000 babies/yr in the US 4,000 infants/year with Critical Congenital Heart Disease (CCHD) in US 130,000 infants/year globally About 2,000 infants/year die or have missed diagnosis in US 65,000 globally

7. 2014 Summit Co-Convener:Founder:

8. 2014 Summit Co-Convener:Founder: Seminal Study Pre- & post-ductal pulse oximetry (Masimo SET ® ) measurements on 39,821 newborns in Sweden Physical exam alone identified 63% of babies with CCHD With pulse oximetry, CCHD detection increased to 83% No babies died of CCHD in pulse oximetry screening group 5 babies died of CCHD in a prospective cohort group Granelli AD, Wennergren M, et al. BMJ 2009; 338: A3037.

9. 2014 Summit Co-Convener:Founder: CCHD Work Group Recommendations (2011) “Newborn screening should be done with “motion-tolerant pulse oximeters that report functional oxygen saturation, have been validated in low perfusion conditions” Kemper AR et al. Pediatrics 2011; (10.1542/peds.2011-1317 )

10. 2014 Summit Co-Convener:Founder:

11. 2014 Summit Co-Convener:Founder: Potential hazards of high and low oxygen saturation targets in preterm infants High SpO 2 target Retinopathy of Prematurity Chronic Lung Disease Periventricular Leukomalacia Cerebral Palsy Low SpO 2 target Patent Ductus Arteriosus High pulmonary vascular resistance Cognitive and motor delay Cerebral palsy Death Askie LM et al. Pediatr Res 2001; 50: 712-719. Haynes RL, et al. J Neuropathol Exp Neurol 2003; 62: 441-450

12. 2014 Summit Co-Convener:Founder:

13. 2014 Summit Co-Convener:Founder: Closing the Gap Universal screening for all babies Appropriate monitoring and oxygen targeting for neonates

14. 2014 Summit Co-Convener:Founder: Patient Safety Science & Technology Summit 2014

15. 2014 Summit Co-Convener:Founder: Peter Cox, MB, ChB Assc. Chief, Department of Critical Care Medicine Hospital for Sick Children Toronto Ontario Anne de-whal Granelli, MD Biomedical Scientist, RDCS(PE) Mitch Goldstein, MD Assc. Professor, Pediatrics Division of Nanotechnology Loma Linda University Children’s Hospital Lisa A. Horn Clinical Program Manager for the CCHD Screening Program Children’s National Health System Jennifer Howes, PhD President March of Dimes Annamarie Saarinen Co-Founder and Chairman Newborn Foundation / Coalition Neonatal & Pediatric Patient Safety Update

16. 2014 Summit Co-Convener:Founder: Neonatal & Pediatric Patient Safety Update

17. 2014 Summit Co-Convener:Founder: Patient Safety Science & Technology Summit 2014