2. months for 2 x 10 years11/2009 best 11/2009 cost Processing18100 x8x4 GIPS$5/GIPS Storage (disk) 121,000 x2 TB$0.10/GB LAN BW18100 x10 GB/s$1/MB/s WAN BW121,000 x4 GB/s$1000/MB/s/mo Display pixels36010 x4 M$100/M Implication: spend hardware to simplify software. Huge components work (OS, database, browser) Better hardware enables new applications. Complexity goes into software.

3. Simulation 1950- today nuclear weapons, payroll, protein folding, games, virtual reality Communication (storage) 1980- today email, airline tickets, books, movies, Bing, Virtual Earth Embodiment (physical world) 2010-... factories, cars, robots, smart dust

4. UNFOLDING OF THE DNA BINDING DOMAIN OF HIV INTEGRASE HIV uses proteins to insert its genetic code into our DNA. The DNA binding domain of HIV integrase (below) is the protein which HIV uses to grab onto our DNA such that it can then connect its genetic code into ours.

6. 256 bytes of RAM, $199

15. Reduce highway traffic deaths to zero

17. video

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