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Gene Ontology Project

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Presentation on theme: "Gene Ontology Project"— Presentation transcript:

1 Gene Ontology Project http://www.geneontology.org/

2 http://www.geneontology.org/cgi-bin/biblio.cgi 450 1063 publications over 284 Journals Who is citing GO?

3 Week ending 25th September 2006

4 1.National Institute on Alcohol Abuse and Alcoholism (NIAAA) 2.National Institute on Aging (NIA) 3.National Institute of Allergy and Infectious Diseases (NIAID) 4.National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) 5.National Center for Complementary and Alternative Medicine (NCCAM) 6.National Cancer Institute (NCI) 7.National Institute on Drug Abuse (NIDA) 8.National Institute on Deafness and Other Communication Disorders (NIDCD) 9.National Institute of Dental & Craniofacial Research (NIDCR) 10.National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) 11.National Institute of Biomedical Imaging and Bioengineering (NIBIB) 12.National Institute of Environmental Health Sciences (NIEHS) 13.National Eye Institute (NEI) 14.National Institute of General Medical Sciences (NIGMS) 15.National Institute of Child Health and Human Development (NICHD) 16.National Human Genome Research Institute (NHGRI) 17.National Heart, Lung and Blood Institute (NHLBI) 18.National Library of Medicine (NLM) 19.National Center on Minority Health and Health Disparities (NCMHD) 20.National Institute of Mental Health (NIMH) 21.National Institute of Nursing Research (NINR) 22.National Institute of Neurological Disorders and Stroke (NINDS) 23.National Center for Research Resources (NCRR) 24.Fogarty International Center (FIC) Sample of 77 research papers, both intra-mural & extra-mural research. NIH funded experimental research that uses the GO

5 Companies NLP & Ontology Products BioWisdom, IBM Array Products and data analysis Affymetrix, Spotfire Products that use GO Clontech, Inpharmatica Reagents & services Sigma, Abnova Big Pharmas AstraZeneca

6 Clark et al., 2005 part_of is_a

7 Clark et al., 2005

8 Whole genome analysis (J. D. Munkvold et al., 2004)

9 attacked time control Puparial adhesion Molting cycle hemocyanin Defense response Immune response Response to stimulus Toll regulated genes JAK-STAT regulated genes Immune response Toll regulated genes Amino acid catabolism Lipid metobolism Peptidase activity Protein catabloism Immune response Bregje Wertheim at the Centre for Evolutionary Genomics, Department of Biology, UCL and Eugene Schuster Group, EBI. …analysis of high-throughput data according to GO MicroArray data analysis

10

11 P05147

12 PMID: 2976880

13 P05147 PMID: 2976880 GO:0047519

14 P05147 PMID: 2976880 GO:0047519 IDA

15 P05147 PMID: 2976880 GO:0047519 IDA

16 P05147 PMID: 2976880 GO:0047519 IDA

17

18 Clark et al., 2005 part_of is_a

19 Clark et al., 2005 part_of is_a

20 Whole genome analysis (J. D. Munkvold et al., 2004)

21 attacked time control Puparial adhesion Molting cycle hemocyanin Defense response Immune response Response to stimulus Toll regulated genes JAK-STAT regulated genes Immune response Toll regulated genes Amino acid catabolism Lipid metobolism Peptidase activity Protein catabloism Immune response Bregje Wertheim at the Centre for Evolutionary Genomics, Department of Biology, UCL and Eugene Schuster Group, EBI. …analysis of high-throughput data according to GO MicroArray data analysis

22 http://www.psb.ugent.be/

23 2006 Consortium Meeting, St. Croix, U.S. Virgin Islands, March 30 - April 3, 2006

24 Contributors dictyBase FlyBaseGeneDB Gramene ReactomeWormBase The GO Editorial Office Berkeley Bioinformatics and Ontology Project (BBOP) Gene Ontology Annotation @ EBI (GOA) Mouse Genome Database (MGD) and Gene Expression Database (GXD) Rat Genome Database (RGD) Saccharomyces Genome Database (SGD) The Arabidopsis Information Resource (TAIR) The Institute for Genomic Research (TIGR) Zebrafish Information Network (ZFIN)


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