1. Life Sciences Trend Analysis 2013 GERMANY

2. About Us The following statistical information has been obtained from Biotechgate. Biotechgate is a global, comprehensive, Life Sciences database encompassing the Biotechnology, Pharmaceutical and Medical Device industries. www.biotechgate.com www.biotechgate.com The German Biotech Database is a part of the global Biotechgate and is brought to you in partnership with BIO NRW - Cluster Biotechnology North Rhine-Westphalia; representing an active, multicentric network developing into a technological pacesetter for NRW’s life science business. www.germanbiotech.comwww.germanbiotech.com Biotechgate is owned and operated by Venture Valuation AG, a Zurich based company specializing in independent assessment and valuation of technology-driven companies in high growth industries, such as the Life Sciences (Biotech, Pharma, Medtech), ICT, high-tech, Nanotech, Cleantech and Renewable energy. www.venturevaluation.comwww.venturevaluation.com

3. Status of the Sector 2012 Statistics Germany 2013 Statistics 836Total Biotech Companies991 139Biotech - Therapeutics162 561Biotech - R&D Services661 136Biotech - Other168 92%Percentage of SME's91% 3%Percentage of Publicly Owned Companies2% USD 176 M (2011) Financing/Capital Raised USD 261 M (2012) 329Licensing Opportunities411

4. Key Activities of Biotechnology Companies Historical Data Subsector2013 2012 Bioinformatics and Bioelectronics 5% Contract Research and Manufacturing 13%12% Diagnostics and Analytical Services 24%23% Genomics and Proteomics 8% Other Services and Suppliers 27%28% Therapeutics 8%9% Other15%

5. Company Foundation Timeline

6. Company Ownership Historical Data Subsector 2013 2012 Private/ Independent 84%85% Public 2% Subsidiary14%13%

7. Sources of Company Foundations Historical Data Company Foundation 2013 2012 Independent foundation 48%59% Spin-off from company 2%3% Spin-off from public institution / NPO 4%6% Spin-off from university 9%12% Subsidiary 11%14% Other3%4%

8. Number of Employees Historical Data No. of Employees 2013 2012 1-10 24%23% 11-50 47%50% 51-200 20%19% Greater than 2009%6%

9. Products in the Pipeline

10. Financing Rounds in Germany & 3 Major Financing Rounds Financing for 2012/2013 Private Biotech Companies Major Financings in 2012/2013SectorUSD M Curevac GmbH Biotech – Therapeutics & Diagnostics 103 Brain AGBiotech – Other77 Affimed Therapeutics AG Biotech – Therapeutics & Diagnostics 20

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12. Terms of Use The “German Life Sciences Trend Analysis” is based on data entered in the Biotechgate Database available at www.biotechgate.com. The statistics and graphs in this presentation are based on figures and information entered in this database and we do not guarantee any accuracy hereof. The use of the figures and graphs provided in this report is free of charge for any presentations as long as www.biotechgate.com is clearly cited as the source. For all other uses please contact us for terms and conditions. Biotechgate c/o Venture Valuation VV AG Kasernenstrasse 11+41 (43) 321 86 60 8004 Zurichinfo@venturevaluation.com Switzerlandwww.venturevaluation.com