1. Lecture 11 – Second Messengers V – MAP Kinase & Phospholipase D Signalling BIOL 5190/6190 Cellular & Molecular Singal Transduction Prepared by Bob Locy Last modified -13F

2. CSB Fig 02:01 Cell signalling pathways CSB Fig 02:01 Cell signalling pathways Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

3. Transducers Second Messengers II 1.MAP kinase signaling ERK pathway ERK pathway JNK pathway JNK pathway p38 pathway p38 pathway 2.Phospholipase D signaling 3.Shingomylin Signaling

4. Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 CSB Fig 2:61 ROS microdomains CSB Fig 2:61 ROS microdomains

5. Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 CSB Fig 2:62 ERK signalling CSB Fig 2:62 ERK signalling

6. Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 CSB Fig 2:63 JNK signalling CSB Fig 2:63 JNK signalling

7. Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 CSB Fig 2:64 NF-kB, IkB, and IKK structure CSB Fig 2:64 NF-kB, IkB, and IKK structure

8. Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 CSB Fig 2:65 NF-kB activation CSB Fig 2:65 NF-kB activation

9. Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 CSB Fig 2:66 Toll receptor signalling CSB Fig 2:66 Toll receptor signalling

10. Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 CSB Fig 2:67 Virus recognition CSB Fig 2:67 Virus recognition

11. Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 CSB Fig 2:68 PLD isoforms CSB Fig 2:68 PLD isoforms

12. Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 CSB Fig 2:69 PLD signalling CSB Fig 2:69 PLD signalling

13. Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 CSB Fig 2:70 Sphingolipid metabolism CSB Fig 2:70 Sphingolipid metabolism

14. Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 CSB Fig 2:71 Sphingomyelin signalling CSB Fig 2:71 Sphingomyelin signalling