1. VACCINE Group V Eka Putri Dewi (115090107111010) Ferlany Hardiyanti (115090101111009) Nanda Yuli Rahmawati (115090100111010)

2. A vaccine is substance used to stimulate a person’s immunity (protection against) a certain disease. Some vaccines stimulate immunity by encouraging the body to make antibodies (humoral immunity). VACCINE

3. Live attentuanted Form of the wild virus or bacterium Can replicate themselves so the immune response almost similar to natural infection Inactivated Cannot replicate and thus generally not as effective as live vaccines Immune response mostly antibody based KIND OF VACCINE

4. How to make vaccine? Fig 1. Mechanism to make vaccine

5. VIDEO CHECK THIS OUT

6. Even 2,500 Years Ago, People Knew Immunity Worked.  Greek physicians noticed that people who survived smallpox never got it again.  The insight: Becoming infected by certain diseases gives immunity.

7. Vaccination Edward Jenner 1796 : Cowpox/Swinepox 1800’s Compulsory childhood vaccination Fast forward 2300 years

8. Smallpox 1% v. 25% mortality Increase immunity UK: 1700’s China 1950 Pakistan/Afghanistan/Ethio pia 1970 pathmicro.med.sc.edu/ppt-vir/vaccine.ppt Variolation was a huge advance

9. Smallpox As a result, after a world-wide effort Smallpox was eliminated as a human disease in 1979 pathmicro.med.sc.edu/ppt-vir/vaccine.ppt

11.  A live or inactivated substance derived from a pathogen (e.g bacteria or virus)capable of producing an immune response Expose the patient to an Antigen If the patient is subsequently exposed to infectious agent carrying this Antigen they will mount a faster immune response How does vaccination work?

12. Molecular Biology of the Cell Alberts et al Patient exposed to pathogen Carrying antigens A and B It works like this

13. How the Vaccine Work ? Check This Out Our Video

15. Breasts produce colostrum beginning during pregnancy and continuing through the early days of breastfeeding. This special milk is yellow to orange in color and thick and sticky. It is low in fat, and high in carbohydrates, protein, and antibodies to keep the baby healthy. What Is Colustrum ?

16. Colostrum actually works as a natural and 100% safe vaccine. It contains large quantities of an antibody called secretory immunoglobulin A (IgA) which is a new substance to the newborn. Before the baby was born, he received the benefit of another antibody, called IgG, through placenta

17. Colostrum vs Breast Milk

18. Genetically Modified Vaccine

20. Application Of Genetic Engineering In Development Using Bacterial Vaccine Hepatitis Saccharomyces cereviciae To Prevent Hepatitis B Virus Infection