1. Course Module: Introduction to Bioinformatics – CS 2001 July 2002 - CS Databases

2. Course Module: Introduction to Bioinformatics – CS 2001 July 2002 - CS Types of Database  Sequence and Bibliographic  Genomic  Clinical and Mutation  Homologies  Integrated Most databases are accessible from a web page are interlinked

3. Course Module: Introduction to Bioinformatics – CS 2001 July 2002 - CS Sequence Databases Main nucleic acid sequence databases EMBL GenBank DDBJ Main protein sequence databases Swiss Prot also TREMBL, GenPept Often integrated with other databases

4. Course Module: Introduction to Bioinformatics – CS 2001 July 2002 - CS Integrating Sequence and Bibliographic Databases Entrez Links nucleic acid sequences, protein sequences and MEDLINE Powerful and easy to use SRS Universal system for searching sequence and other databases Available worldwide including at HGMP

5. Course Module: Introduction to Bioinformatics – CS 2001 July 2002 - CS Genomic Databases GDB Repository for mapping and genomic data for the Human Genome Project Powerful; links to other databases ACeDB Developed to provide access to C.elegans data

6. Course Module: Introduction to Bioinformatics – CS 2001 July 2002 - CS Clinical and Mutation Databases OMIM Online Mendelian Inheritance in Man Database of disease-linked genes and associated phenotypes Links to Entrez, GDB and other databases HGMD Database of sequences and phenotypes of disease-causing mutations Disease-specific mutation databases

7. Course Module: Introduction to Bioinformatics – CS 2001 July 2002 - CS Homology Databases MGI Mapping and gene expression data for the mouse Human homologies Links to GDB and Entrez Many other organism-specific databases can be used to search for homologs of human genes

8. Course Module: Introduction to Bioinformatics – CS 2001 July 2002 - CS An Integrated Database GeneCards Integrated resource of information on human genes and their products Major emphasis on human disease Links to many kinds of biomedical information Sequence databases OMIM, HGMD, MDB Doctors’ Guide to the Internet

9. Course Module: Introduction to Bioinformatics – CS 2001 July 2002 - CS Database Searching Tips  Look for links to Help or Examples  Try Boolean searches  Be careful with UK/US spelling differences leukaemia vs leukemia haemoglobin vs hemoglobin colour vs color