1. © Cancer Research UK 2008 Registered charity number 1089464 Prostate cancer – UK December 2009

2. © Cancer Research UK 2008 Registered charity number 1089464 Table One: Number of new cases and rates of prostate cancer, UK, 2006 EnglandWalesScotlandN.IrelandUK Cases Males30,0242,1642,50682135,515 Crude rate per 100,000 population Males120.5149.8101.596.2119.6 Age-standardised rate (European) per 100,000 population Males98.1108.281.692.197.1 95% CI97.099.2103.7112.878.484.885.898.496.198.1

3. © Cancer Research UK 2008 Registered charity number 1089464 Figure One: Number of new cases and rates of prostate cancer, by age, UK, 2006

4. © Cancer Research UK 2008 Registered charity number 1089464 Figure Two: Age-standardised* incidence and mortality rates for prostate cancer by world regions, 2002 estimates * to the European standard population

5. © Cancer Research UK 2008 Registered charity number 1089464 Figure Three: Age standardised* (European) incidence and mortality rates, prostate cancer in EU countries, 2006 estimates * to the European standard population

6. © Cancer Research UK 2008 Registered charity number 1089464 Figure Four: Age standardised* (European) incidence and mortality rates, prostate cancer, males, GB, 1975- 2007 * to the European standard population

7. © Cancer Research UK 2008 Registered charity number 1089464 Figure Five: Age-specific incidence rates, prostate cancer, Great Britain, 1975-2006

8. © Cancer Research UK 2008 Registered charity number 1089464 Figure Six: Age-standardised* rates of transurethral resection of the prostate (TURP) and crude rates of PSA testing, Scotland 1981-96 * to the European standard population

9. © Cancer Research UK 2008 Registered charity number 1089464 Figure Seven: Diagram of the prostate

10. © Cancer Research UK 2008 Registered charity number 1089464 Table Two: Treatment and management options for men with localised disease (adapted with permission from NICE (2008) CG58. Prostate cancer: diagnosis and treatment. London. 8 Low-risk men (PSA < 10ng/ml and Gleason score ≤6 and T1- T2a Intermediate-risk men (PSA 10-20 ng/ml or Gleason score 7 or T2b-T2c High-risk men (PSA >20 ng/ml or Gleason score 8-10 or T3-T4) Watchful waiting◊◊◊ Active surveillanceü◊X Brachytherapy◊◊X Prostatectomy◊üü*ü* High dose conformal radiotherapy◊ü†ü†ü*† CryotherapyX* High intensity focused ultrasoundX* ü Preferred treatmentX Not recommended ◊ Treatment option X* Not recommended unless as part of a clinical trial comparing use with established interventions ü* Offer if there is a realistic prospect of†neo-adjuvant ± adjuvant hormone therapy (for Gleason score ≥8) long term disease control is recommended

11. © Cancer Research UK 2008 Registered charity number 1089464 Figure Eight: Rates of radical prostatectomy and orchidectomy, England, 1991–2004 (Adapted with permission from Hussain S et al. BJU Int 2008;101(5):547–55)

12. © Cancer Research UK 2008 Registered charity number 1089464 Figure Nine: Hormone treatment for prostate cancer, UK, 1975–2004 (Adapted with permission from Hussain S et al. BJU Int 2008;101(5):547–55)

13. © Cancer Research UK 2008 Registered charity number 1089464 Figure Ten: One, five and ten-year age-standardised relative survival for prostate cancer, men aged 15-99 diagnosed in England and Wales, 1971–2001

14. © Cancer Research UK 2008 Registered charity number 1089464 Figure Eleven: Five-year age-adjusted relative survival, selected countries in Europe 1990-99 and the US, 1996- 2003

15. © Cancer Research UK 2008 Registered charity number 1089464 Figure Twelve: Relative survival at five years since diagnosis by age, prostate cancer; patients diagnosed 1998-2001, England

16. © Cancer Research UK 2008 Registered charity number 1089464 Table Three: Number of deaths and mortality rates of prostate cancer, UK, 2007 EnglandWalesScotlandN.IrelandUK Deaths Males8,65956379322410,239 Crude rate per 100,000 population Males34.538.731.926.034.2 Age-standardised rate (European) per 100,000 population Males24.724.924.223.524.6 CI 95%24.225.222.927.022.625.920.426.624.225.1

17. © Cancer Research UK 2008 Registered charity number 1089464 Figure Thirteen: Number of deaths and age-specific mortality rates, prostate cancer, UK, 2007

18. © Cancer Research UK 2008 Registered charity number 1089464 Figure Fourteen: Age-specific mortality rates, prostate cancer, UK, 1971-2007