Presentation on theme: "Vulval & Vaginal lesions"— Presentation transcript:
1Vulval & Vaginal lesions Dr. Abdallah H. AlsadigMD
2Vulval anatomy The vulva (external genitalia ) includes: Mons pubis clitorislabia majora and minoraPerineum: a less hairy skin & subcutaneous tissue area lying between the vaginal orifice & the anus & covering the perineal body. Its length is 2-5 cm or more. The urethra opens on to it.Vestibule: a forecourt or a hall next to the entrance. It is the area of smooth skin lying within the L. minora & in front of the vaginal orifice.Hymen.
4Lichen sclerosusComprises 70% of benign epithelial disorders → epithelial thinning, inflammation & histological changes in the dermis.Aetiology: unknownSx: Itching (commonest), vaginal soreness + Dyspareunia. Burning and pain are uncommon.Signs: crinkled skin, L. minora atrophy, constriction of V. orifice, adhesions, ecchymoses & fissures.Dx: Biopsy is mandatoryRx: - emollients, topical steroids.- Testosterone: not effective than petroleum jelly & → pruritus, pain & virilization.- Surgery: avoided unless malignant changes
5Squamous cell hyperplasia Df: thickened skin with white hyperkeratotic patches, excoriation & fissures.Histo: hyperkeratosis, cellular epithelial proliferation with normal maturation & inflammatory response in the dermis (lymphatic & plasma cell infiltration).Aetiology: repetitive surface irritation & trauma from irritants that causing scratching & rubbing.RX: is the same as Lichen sclerosis
6Benign Vulval lumps Bartholin’s cyst. Epidermal inclusion cyst. Skene’s duct cyst.Congenital mucous cysts: arise from mesonephric ducts remnants.Cyst of the canal of Nuck: can give rise to hydrocele in labia maqjora.Sebaceous cyst.Papillomatosis (solid).Fibroma (solid).Lipoma (solid).Condylomata (solid).Cysts are either congenital or arise from obstructed glands.Manifestations arise from the cysts (cosmotic) or from infection.
7Bartholin glands Two in number. Lie posteriolaterally to the vaginal orifice, one on either sideNormally not seen nor felt.If enlarged, can be a painless cyst or painful abscess
8Bartholin Duct Cyst usually unilateral, on the Most common Vulval cyst.usually unilateral, on theposterio-lateral side of theintroitus.usually about 2 cm &contains sterile mucus.Usually asymptomatic.secondary infections →Bartholin's abscess.Rx: excision or Marsupialization.
10Skene's Gland urethra Normally neither seen nor felt are found on each side ofurethraNormally neither seen norfelt
11Skenitis May become swollen and tender, particularly with GC or chlamydiaRx: drainage.Culture for GC, Chlamydia
12Inclusion Cysts of the Vulva Contain creamy, yellow debris & lined with stratified epithelium.Found in the perineum, posterior V. wall & other parts of the vulva.Arise from perineal skin buried at obstetrical injuries.Usually symptomless.Rx: excision.
13Vulval CarcinomaVulval & vaginal cancers are rare (1000 new cases/year in UK).Majority are of epidermal originAge: years.90-95% of Vulval cancer are of Squamous origin.Melanoma of the vulva is second most common type (4-9%).
14AetiologyVulval dermatomes (lichen sclerosis): a common Vulval inflammatory dermatosis (HPV 16 & 33) affecting older women with ↑chance of malignant progression.Vulval Intraepithelial Neoplasia (VIN) : 80% will lead to invasive cancer at 10 years if not treated & 7-8% if treated. VIN3 is a pre-invasive condition.Human papilloma virus (HPV): associated with 30% of Vulval cancer & with 80-90% of Vulval cancer in women less than 50 years of age.Smoking: co-factor of HPV & VIN development.VIN affects mainly L.minora & perineum.
15Classification of VINVIN I - mild dysplasia with hyperplastic vulvar dystrophy with mild atypiaVIN II - Moderate dysplasia, hyperplastic vulvar dystrophy with moderate atypiaVIN III - Severe dysplasia; hyperplastic vulvar dystrophy with severe atypia (it replaces the term carcinoma in situ, Bowen’s disease).Carcinoma in situ
16VIN Dx & RxDx: colposce + biopsiesRx:- low grade VIN: observation.- VIN3: local excision or laser vaporization- Topical immunomodulator: imiquimod
17Vulval Carcinoma Clinical Staging (F.I.G.O.): Stage I : 1a: confined to vulva with <1mm invasion.1b: confined to vulva with a diameter < 2 cm & no inguinal lymph nodes affection.Stage II : limited to vulva with diameter > 2 cm) & no inguinal lymph nodes affection.Stage III : adjacent spread to the lower urethra and/or vagina and/or anus and/or unilateral lymph nodes affection.Stage IV :Bilateral inguinal nodes metastases, involvement of mucosa of rectum, urinary bladder, upper urethra or pelvic bones.Distant metastasis.
18Treatment of Vulval Carcinoma Stage I & II :Radical local excision with 1cm disease–free margin.Stage III & IV :- According to the general health.- Chemotherapy & radiotherapy to shrink the tumour to permit surgery which may preserve the urethral & anal sphincter function.- radical vulvectomy + inguinal L. nodes dissection.- reconstructive surgery with skin grafts or myocutaneous flaps for healing.
19Vaginal Intraepithelial Neoplasia (VaIN) Extremely uncommon (150 times < CIN).70% associated with CIN (extension of the transformation zone into the vaginal fornices).Predisposing factors: similar to those of CIN (HPV), but the age of VaIN is higher than CIN, diethylstilboesterol in utero (metaplastic transformation into the vagina), previous history of CIN), radiotherapy of CA cervix.VaIN is graded 1-3 but is less invasive than CIN:- VaIN1: mild dysplasia.- VaIN2: moderate dysplasia.- VaIN3: severe dysplasia.Dx: V. smear, colposcopy, biopsy (even after hysterectomy).Rx: low grade: observation. high grade: excision, 5-fluoroyracil, diathermy. Alternatively, Radiotherapy.
20Vaginal Carcinoma Incidence: 1-2% of all gyn. Cancer. Classification: 1. primary: squamous (common, 85%), adenocarcinoma (17-21 years of age, metastasis to L.Ns), clear cell adenocarcinoma (DES).2. secondary: metastasis from the cervix, endometrium,…..others.50% in the upper 3rd, 30% in lower 3rd & 19% in middle 3rd.Posterior V. lesions more common than anterior & the anterior are more common than lateral lesions.Spread: direct & lymphatic.
21Clinical Staging (F.I.G.O.): Vaginal CarcinomaClinical Staging (F.I.G.O.):Stage I: tumour confined to vagina.Stage II : tumour invades paravaginal tissue but not to pelvic sidewall.Stage III : tumour extends to pelvic sidewall.Stage IV :a) tumour invades mucosa of bladder or rectum and/or beyond the true pelvis.b) Distant metastasis.
22TREATMENT Stage 1: 1. Tumour < 0.5 cm deep: a. surgery: local excision or total vaginectomy with reconstruction.b. radiotherapy.2. Tumour > 0.5 cm deep: (a) wide vaginectomy, pelvic lymphadenectomy + reconstruction of vagina. (b) radiotherapystage 2: (a) radical vaginectomy, lymphadenectomy (b) radiotherapyStage 3: radiotherapy.