1. Challenging Cases From Clinical Practice Eric E. Schmidt, O.D., FAAO Omni Eye Specialists Wilmington, NC schmidtyvision@msn.com

2. A Diagnostic Quandary 76 y/o WM cc: OD hurts, “like a toothache” Pain is worse at night, lasts for 3-6 hrs. 3 occurrences over past 2 weeks VA has decreased since 1 st episode Type I DM – BS 130 today, sliding scale MD says BP is “way hi recently” BP med

3. Quandary Exam VA – OD 20/100 ph 20/80-2 OS 20/40 ph NI  EOM – no rest.  PERRL mg (-)  SLE – K – cl OU  Conj – cl OU  Lens – 2+/2+/1+ OD, 2+NS, 1+PSC OS  AC – quiet OU, Gr 2 VH OU  IOP – 18 OD, 18 OS

4. Quandary cont Gonio – OD 3,2,2,1 OS 2,2,2,2 DFE – Should you dilate these eyes?

5. Quandary Retina NPDR OU (OS > OD) No CSME No NVD, NVE C/D -.3/.3 OU Anything else?

6. What is your differential diagnosis? How you treat this depends upon your diagnosis!!!>>>@@@@****

7. Quandary options Cataract extraction PI OU Glaucoma drops Blood work Refer to Internist Refer to Retina SLT OU Retinal/ONH Imaging

8. I Rx’d Lumigan OU QHS Ordered labs – CBC – low RBC – ESR – 80mm/Hr – A1c – 5.3 – C-RP – normal 2 wk f/up

9. 2 week exam Pain had returned even w/ Lumigan VA worsening AC- mild cell OD, d & q OS Angles – unchanged OU IOP – 17mm OU Retina – scattered h/MA OU, disk heme OS Does this change your mind?

10. TA biopsy vs PI Pros and cons for each How did our man end up?

11. A Strange Cup Of Tea 68 y/o African –American Treated for NTG x 12 yrs Seidel’s scotomas OU Notch at 2:00 OS NTG well controlled w/ Lumigan OU QHS – (IOP ~ 11mm Hg) VF and rims now stable VA stable at 20/20 OU

12. Routine Follow-Up? No subjective complaints VA OD 20/30, OS 20/20 NI w/ refraction When asked again – OD did feel “kind of funny.” PERRL mg (-), EOM- no restrictions SLE – OS normal - OD as shown

13. Oh Yeah... IOP 42mm Hg OD, 14mm Hg OS What’s your next step? What is your differential diagnosis?

14. Glaucomatocyclitic Crisis Unilateral increased IOP w/ accompanying iritis No predispositioning, no precursors Absence of all other findings Mildly symptomatic Diagnosis of exclusion R/O ACG, NVG, Inflammatory G, PDS

15. Treatment Gonio is the key to the diagnosis Lower IOP – Aqueous suppressors Quiet the anterior chamber reaction – PF QID – Taper quickly IOP sequelae?

16. Case Of The Sudden Vision Loss 17 y/o BM awoke that AM; “couldn’t see” out of OS. “somewhat painful” Looked in mirror, noticed eye was totally white Denies trauma No precursors

17. Exam VA s Rx - OD 20/30, OS LP Pupils - OD Round, reactive no inverse APD, OS - not visible SLE - OD prominent K nerves, no edema, no bulb inj, OS as shown IOP 15 OD, 32 OS

18. Sudden Loss Question 1 What other tests would you perform? 1. Gonioscopy 2. Keratometry/Topography 3. DFE 4. Corneal pachometry 5. VF 6. Gonio & K Topo 7. DFE & Gonio 8. Pachometry & Keratometry

19. Sudden Loss Question 2 What Is Your Diagnosis? 1. Angle Closure Glaucoma 2. Corneal Edema 3. Corneal Hydrops 4. Corneal Perforation 5. Pupillary block glaucoma 6. Fuch’s dystrophy

20. Sudden Loss Question 3 How would you treat it? 1. Adsorbonac 5% QID, TXE 0.5OS 2. Penetrating Keratoplasty 3. Betimol 1/2% OS BID, Eflone QID 4. Pressure patch, Atropine OS 5. BCL, Quixin OS QID 6. BCL, Lotemax OS QID 7. Eflone OS QID, Adsorbonac 5% OS QID

21. The Case Of The Low IOP The history : – 72 y/o BF w/ long-standing POAG – Trusopt BID, Xalatan QHS, Betimol ½ BID – IOP - hi teensOU – C/D -.8/.8 OD, 85/.85OS lamina visible OU – VF- OD mild double arcuate OS- Seidel’s scotoma sup VA – OD 20/70 OS 20/25 SLE – cataracts OD > OS

22. Low IOP cont Px underwent combined procedure OD 6 wks S/P surgery VA OD 20/20 – IOP 3 OD, 21 OS – G meds OS Only 2 ½ years later: – Pain OD, VA 20/50 OD – 3+ bulb inj, 2+ AC cell – IOP – 3mm OD, 17mm OS – Fundus- hazy view

23. What is your management plan? 1. EP QID OD 2. EP Q2H OD 3. Atropine ½% OD, PF OD QID 4. Retinal referral 5. Glaucoma referral 6. Vigamox OD QID

24. I Rx’d EP OD QID, HA5% OD BID 2 days later- – VA 20/50-2 – Eye feels better – AC rxn 1+ cell – DFE- as shown

25. What is your diagnosis? 1. Choroidal detachment 2. Posterior Uveitis 3. Retinal detachment 4. Retinoschisis 5. Retinal tear

26. What are you going to do with this? 1. Retinal referral 2. Glaucoma referral 3. Pred Forte OD Q2H 4. Close observation 5. Run out of the door screaming! 6. Calling Dr McGreal!

27. Why has this occurred? Prolonged hypotension? Bleb problems? Ciliary body shutdown? Prolonged uveitis? **** Check The Bleb****

28. 2 holes in surface of bleb Now what? – 1. BCL – 2. Vigamox OD QID – 3. PF QID – 4. BCL, TXE ½ QAM – 5. BCL, Vigamox TID – 6. Vigamox TID, TXE ½ QAM – 7. Vigamox TID, TXE ½ QAM, BCL

29. Trabeculectomy post-op Don’t want IOP too low for too long Bleb management is the key – IOP hi, bleb hi – IOP hi, bleb flat – IOP low, bleb low – IOP low, bleb high Know what to look for, know how to treat

30. Causes of Ocular Hypotony 1. Wound Leak 2. Ciliary Body Shutdown 3. Choroidal detachment 4. Retinal Detachment 5. Uveitis

31. Choroidal Effusion Accumulation of Fluid in suprachoroidal space Caused by trauma, hypotony or inflammation Clinical Features: – Anterior displacement of choroid in annular, lobular or flat arrangement – Must differentiate from RD – Can occur days, weeks or months post-op

32. Choroidal detachment CONSERVATIVE TREATMENT!!! PANIC NOT!!!! – Patch if wound leak – Monitor closely if no wound leak – Try to elevate the IOP – Steroids???

33. The Case Of The “Sore Eye” 17 y/o WM CC: “Itch and Pain OD” 3 weeks duration and it’s getting worse Initially very itchy, now it is painful FB sensation, photophobia, tearing No known trauma, Rx’d Vasocon TID Ext – Ptosis RUL, frank injection SLE – AC –d & q, 1+ mucus d/c

34. What is the diagnosis? 1. Allergic conjunctivitis 2. Corneal abrasion 3. Bacterial keratitis 4. Dellen 5. Vernal keratoconjunctivitis

35. How Do You Know It’s Not Infectious???

36. What Is The Best Treatment? 1.BCL and Gentamicin QID 2. BCL and Xibrom BID 3. BCL and Zymar QID 4. Lotemax OD QID 5. Vigamox OD TID 6. Tobradex OD QID 7. Vigamox and Nevanac TID each 8. Some combination of these

37. Does She Or Doesn’t She? A Glaucoma Conundrum – 51 y/o WF – No family hx of G – BCVA 20/20 OD, OS – SLE – normal – C/D -.65/.75 OD,.65/.70 OS – IOP – 23 OD, 23 OS @ 8:40 AM – 22/22 @10:20AM, 25/26@3:30PM – Does she have glaucoma?

40. Based on this info would you... Start therapy? Get more data? Follow with routine care?

41. Additional Information Gonioscopy – Gr 4 360 degrees OU PMH: Htn, hypercholesterolemia Meds: Vasotec, Lipitor Pachs – OD 652, OS 668 Now would you treat?

42. Now what would you do? What is her “actual “ IOP? What is your target IOP for her? What type of glaucoma does she have? Which drop would you prescribe?

43. One last piece of the puzzle In our office IOP readings were... – 23/21 gat, 18.0/16.3 Pascal – 23/21 GAT, 18.3/17.3 Pascal Does this change anything?

44. As Many Disease As She Pleases 77 WF Macular hole repair OS 8 yrs prior Subsequent SRNVM w/ large macular scar VA OD 20/20, OS HM@6’ – stable for 5 yrs Recently complained of HA “alot” over OS Says her vision OS is worsening, “it will go black at times!”

45. Exam VA OD 20/25- OS – LP SLE – OD no change, OS – 2+ PCO DFE –OD - D,M,V,P wnl OS small macular bleed adjacent to macular scar ONH -.1/.1 OD pink,.15/.15 OS large area of PPA What now? Did we forget something?

46. Ancillary Tests IVFA – no evidence of new SRNVM OCT – Plush NFL, no SRNVM ESR – 20mm/Hr C-RP – 0.8 What now? Is she just crazy? Are you sure we haven’t overlooked anything?

47. Explain the VF result NOW what would you do?

48. MRI Suprasellar mass with impingement on ON Probable glioma Underwent resection Craniopharyngioma!

49. The Case of Newfound Eyes 70 y/o F referred for chronic sore eyes POH: Punctal plugs 3 yrs prior – moderate improvement initially Meds: Synthroid, Adalat, Calcium, ASA, Refresh Tears QID CC: Eyes burn and sting. Very red worse at times. Mild stringy d/c. Vision seems worse “I’m Allergic to everything!”

50. Newfound Data VA OD 20/25, OS 20/30 Ext: normal except for “ruddy” complexion SLE: Lids – 1+ debris OU 1+ Meib inspissation OU 1+ bulb injection few papillae OU K – diffuse SPK OU Lens – 1+ NS OU

51. Which test do you want to do next? 1.Amsler grid 2.Corneal topography 3.Rose-Bengal Stain 4.Schirmer’s strip 5.TBUT 6.Zone Quik

52. What is your diagnosis? 1. Ocular Surface Disease 2. Blepharitis 3. Ocular rosacea 4. VKC 5. Allergic conjunctivitis 6. Bacterial conjunctivitis

53. What is the clinical key to making this diagnosis? 1. Look under the lids – check for papillae 2. Look at the cornea – check for RB staining 3. Look at her tears – check Schirmer’s test 4. Look at her cheeks – check for telangiectasia 5. Look at her daughter – check for a wedding ring

54. Considering that… She has punctal plugs, She is using Patanol OU BID She is using AT a lot Has a Schirmer’s test of 3mm OD, 6mm OS She has corneal staining She continues to be symptomatic

55. How are you going to treat Newfound? 1. Doxycycline 100mg QD 2. Lotemax OU QID 3. Systane OU Q2H 4. Refresh PM ung OU QHS 5. Polysporin Ung OU QHS 6. Restasis OU Q12H 7. Acular LS OU TID 8. Some combo of these

56. What I Did with Newfound RX Doxy 100 QAM FML OU QID AT PRN 1mth later she felt much better, lids were much clearer, no NaFl or RB staining Now what?

57. Long term therapy for Newfound? 1. Doxy 50 QD and AT 2. Optive OU QID 3. Restasis OU BID and AT OU QID 4. Restasis BID and Doxy 50 QD 5. FML OU BID and AT BID 6. Lotemax BID and Restasis BID 7. Doxy 100 QD and AT TID 8. Vitamins and Flax seed oil