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Brain tumor.

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Presentation on theme: "Brain tumor."— Presentation transcript:

1 Brain tumor

2 WHO Histologic Classification of CNS tumors:
Neuroepithelial Tumors Astrocytic tumors Oligodemdroglial tumors Ependymal tumors Mixed gliomas Choroid plexus tumors Neurologic tumors Pineal parenchymal tumors Embryonal tumors Tumors of cranial/spinal nerves Mesenchymal tumors, benign Mesenchymal tumors, malignant Uncertain histogenesis Hemopoietic neoplasms Cysts/tumorlike lesions Sellar tumors

3 Prognostic Factors: for malignant astrocytomas
Age Tumor type Performance status Extent of surgery

4 Principles of Treatment:
Surgery: initial treatment Radiotherapy Chemotherapy Combine treatment

5 Estimated Survival: 5 years (%)
Astrocytoma Grade I (cerebellar) Grade I (all sites) 50-60 Grade II Grade III Grade IV 0-10 Medulloblastoma Ependymoma Oligodendroglioma Brain stem 3rd ventricle+midbrain 25-35 Pinealoma

6 Roles of Radiotherapy in Brain Tumor
Incomplete surgery Deep seated tumor: midbrain, pons Radiosensitive tumor: medulloblastoma Pituitary adenoma Palliation: metastatic lesions

7 Roles of Whole Cerebrospinal Axis Irradiation:
Medulloblastoma Ependymoma: esp. poorly differentiated type Malignant glioma of posterior fossa Pinealoma Choroid plexus papilloma Reticulum cell sarcoma of the brian

8 Complications and Late Effects of Radiation:
Acute reaction Brian edema Early delayed reaction Necrotizing leukoencephalopathy Somnolence Syndrome Late delayed reaction Cerebral Necrosis Optic nerve injury

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