Presentation on theme: "Ticks, Mites and Associated Pathogens"— Presentation transcript:
1Ticks, Mites and Associated Pathogens Overview:Characteristics of the subclass Acari (ticks and mites)Metastigmatid mites = ticksTicks and tick-borne pathogensAll other mites….Mites and mite-borne pathogens
2Ticks and Mites (Subclass Acari) 1. Class Arachnida (Also includes spiders and scorpions2. Characteristics of Acari (mites and ticks):a. sac-like, unsegmented bodyb. highly specialized mouthparts, capitulum w/ hypostomec. phytophagous, predatory, parasiticd. larvae 6 legs, nymph & adult 8 legse. 4-stage life cycle, egg-larva-nymph-adult
3Ticks and Mites - Classification Class ArachnidaSubclass AcariOrder Ixodida (= Metastigmata) (ticks)Order Mesostigmata (free-living, predaceous, and parasitic mites)Order Prostigmata (chiggers, follicle mites)Order Astigmata (house dust, storage & scabies mites)
4Ticks - Classification Class ArachnidaTicks (3 families):IxodidaeArgasidaeNuttalliellidaeSubclass AcariSuperorder ParasitiformesOrderSource:
5Mites - Classification Class ArachnidaSubclass AcariMesostigmatid MitesSuperorder ParasitiformesOrderSource:
7Ticks and Mites - Classification Recent validation of Acari suborders (ticks are ticks and mites are mites)Recent reorganization within the ticksJ. S. H. Klompen, William C. Black IV, James E. Keirans, and Douglas E. Norris Systematics and Biogeography of Hard Ticks, a Total Evidence Approach. Cladistics 16, 79–102.Ivan G. Horak, Jean-Louis Camicas and James E. Keirans The Argasidae, Ixodidae and Nuttalliellidae (Acari: Ixodida): a world list of valid tick names. Experimental and Applied Acarology 28: 27–54.
10TICKS Characteristics of Ixodida (ticks) - approx. 900 species a. largest of acarines - larger than mitesb. toothed hypostomec. Haller's organ (sensory pit on tarsi of first pair of legs)d. absence of claws on palpse. evolved as parasites of reptiles, adaptation to mammals associated with general reduction in body sizeTick Families: Ixodidae - Hard Ticks, Argasidae – Soft Ticks, Nuttalliellidae - rare, S. Africa (single species)
12Family Ixodidae Hard Ticks (approx. 683 species, 12 genera) Features:a. sexual dimorphism, male - enlarged scutum, female - shieldb. mouthparts (capitulum) visible dorsallyc. feed only once during each stage, often diurnal, males show little size increased. range parasites, questing from vegetation, one large egg batch
14Typical Life History of Hard Ticks (most three-host): a. One-Host: Rhipicephalus (Boophilus) annulatus (Texas Cattle Fever Tick), all stages on same host, but leave host to molt, control using pasture rotationb. Three-Host: Dermacentor variabilis (American Dog Tick), each stage uses a different host - larva on small rodents, nymph on larger mammal, adult on another large mammal. Other three host: Rhipicephalus sanguineus (Brown Dog Tick) Amblyomma americanum (Lone Star Tick)
15Description of medically-important hard ticks: Genus Approx. # Species DistributionWorld U.S.Amblyomma worldwide, mostly tropicalDermacentor worldwideHyalomma Africa, AsiaNosomma India, SE AsiaRhipicephalus Ethiopian / tropicopolitan(includes Boophilus)Haemaphysalis worldwideIxodes worldwideMargaropus southern, east AfricaBothriocroton Austrailia
16Genus Ixodes: Largest genus of hard ticks Ixodes ricinus/persulcatus complex - Lyme Disease, HGEI. ricinus (European Sheep tick) through Europe, Turkey, IranI. persulcatus (Taiga tick) EurasianI. scapularis (Black-legged tick) eastern USI. pacificus (Western Black-legged tick) western US.I. holocyclus Australia (tick paralysis)I. rubicundus (Karoo tick) South Africa
17Genus Haemaphysalis: Small, both sexes similar, important in enzootic cycles H. leporispalustris (Rabbit tick) western hemisphere distribution (important maintenance vector for tularemia and RMSF)Genus Hyalomma: Large unornamented ticksH. marginatum Russian states, southernEurope (Crimean-Congo hemorrhagic fever)
18Genus Rhipicephalus: African origin, but several species worldwide in the tropics (now includes previous species of Boophilus, non-ornamented, one-host ticks)R. sanguineus (Brown Dog tick) cosmopolitandistribution (RMSF, boutonneuse fever)R. (Boophilus) annulatus (Cattle Fever tick) southern US, Mexico (Texas Cattle fever, field rotation for control)R. (Boophilus) microplus (Southern cattle tick) Australia, Mexico, S. America
19Genus Dermacentor: Ornate ticks D. variabilis (American dog tick) eastern US, Canada, Mexico (tularemia, RMSF)D. andersoni (Rocky Mountain wood tick) western North America (tularemia, RMSF, Colorado tick fever)D. albipictus (Winter tick) across CanadaD. occidentalis (Pacific coast tick) Oregon, California
20Genus Amblyomma: Large ornate ticks A. americanum (Lone Star tick) central/eastern US - S. American (RMSF, tularemia)A. cajennense (Cayenne tick) Texas, S. America, CaribbeanA. hebraeum (Bont tick) S. Africa
21Family Argasidae Soft Ticks (183 species, 4 genera)Features:a. slight sexual dimorphism, only slightswelling from feedingb. scutum absentc. capitulum not visible dorsallyd. palpi leg-like and flexiblee. intermittant "rapid" feeder, nocturnalf. sometime several nymphal instars, somenon-feeding larvaeg. lair parasites, several egg batches,dry adverse environments
23Typical life history of soft ticks: a. Many-host cycle. Often one larval host and several nymphal and adult hosts. Adult female lays eggs after each feedingArgas persicus (Fowl Tick) chicken houses, bird nests, cosmopolitanOrnithodoros moubata (African Relapsing Fever Tick) feeds on sleeping humans, southern AfricaOtobius megnini (Spinose Ear Tick) adult non-feeding, nymph problem
24Description of medically-important soft ticks: Genus Approx. # species DistributionArgas worldwideOrnithodoros 38 worldwideOtobius 3 western hemisphereCarios worldwide
25Genus Argas: most nocturnal bird-associated A. persicus (Fowl tick) cosmopolitan (economic importance, painful bite)A. arboreus east, S. Africa (arbovirus vector)
26Genus Ornithodoros: Reservoirs and vectors of relapsing fever O. moubata (African Relapsing Fever tick) S. Africa (species complex) numerous speciesGenus Otobius: Adults do not feedO. megnini (Spinose ear tick) western hemisphere, Africa, India (nymphal infestations in ears)
27Tick Sampling Tick Control a. observation on hosts and premises b. Dragging/flaggingc. CO2 - baited trapsTick Controla. Natural predatorsb. Repellents/toxicants for human useI. DEET (apply to skin)II. Pyrethroids (apply to clothing)
28Cultural/mechanical control I. remove harborage for hosts/ticksII. destroy hostsIII. pasture rotation (one-host only)Resistant livestockAnti-tick vaccineChemical control on animal host, oracaricide in habitat
29AVOIDING TICKSWear light-colored clothing to allow you to see ticks that are crawling on your clothing.Tuck your pants legs into your socks so that ticks cannot crawl up the inside of your pants legs.Apply repellants to discourage tick attachment. Repellents containing permethrin can be sprayed on boots and clothing, and will last for several days. Repellents containing DEET (n, n-diethyl-m-toluamide) can be applied to the skin, but will last only a few hours before reapplication is necessary. Use DEET with caution on children. Application of large amounts of DEET on children has been associated with adverse reactions.
30AVOIDING TICKS - IIConduct a body check upon return from potentially tick-infested areas by searching your entire body for ticks. Use a hand-held or full-length mirror to view all parts of your body. Remove any tick you find on your body.Parents should check their children for ticks, especially in the hair, when returning from potentially tick-infested areas. Additionally, ticks may be carried into the household on clothing and pets. Both should be examined carefully.
31Removal of an embedded tick using fine-tipped tweezers. Tick Removal:1. Use fine-tipped tweezers or shield your fingers with a tissue, paper towel, or rubber gloves. When possible, persons should avoid removing ticks with bare hands.2. Grasp the tick as close to the skin surface as possible and pull upward with steady, even pressure. Do not twist or jerk the tick; this may cause the mouthparts to break off and remain in the skin.Removal of an embedded tick using fine-tipped tweezers.
323. Do not squeeze, crush, or puncture the body of the tick because its fluids (saliva, body fluids, gut contents) may contain infectious organisms.4. After removing the tick, thoroughly disinfect the bite site and wash your hands with soap and water.5. Save the tick for identification in case you become ill. This may help your doctor make an accurate diagnosis. Place the tick in a plastic bag and put it in your freezer. Write the date of the bite on a piece of paper with a pencil and place it in the bag.
36Photograph copyright 2001 Steve Barker Otobius megnini
37Medical Importance of Ticks 1. Dermatosis - inflammation, itching , swelling at site of bite2. Exsanguination - anemia can result from heavy infestation3. Otoacariasis - auditory canal infestation, poss. secondary infection4. Predispose to myiasis and infection5. Tick paralysis (envenomization)6. Pathogen transmission (virus, rickettsia, bacteria, spirochaete, protozoa, filarial worms)
38Factors Accounting for High Vector Potential of Ticks 1. Persistent hematophagous feeders2. Relatively slow feeding time allows time for pathogen transfer3. Typically have a wide host range4. Longevity increases chances of acquiring and transmitting a pathogen5. Transovarial transmission of some pathogens6. Few natural enemies, highly sclerotized (resistant to environmental stress)7. High reproductive potential - up to 18,000 eggs and parthenogenesis in some species
40Some Tick-Borne Pathogens Human monocytic ehrlichiosis (HME), caused by Ehrlichia chaffeensis a new monocytotropic ehrlichia, was discovered in 1986 and human granulocytic ehrlichiosis (HGE), caused by the HGE agent (newly named Anaplasma phagocytophilum), a new granulocytotropic ehrlichia, was discovered in 1994.In 1999 another granulocytotropic ehrlichia, E. ewingii which was previously known as a canine pathogen has been recognized as human pathogen. E. sennetsu (renamed to Neorickettsia sennetsu) is another monocytotropic Ehrlichia sp. and the first human pathogen discovered in Japan in the 1950’s and recently found in Malaysia.
41This phylogram is constructed based on 16S rRNA sequences of these species. Nomenclature has been changed from original names based on 16S rRNA sequences which divided them into four genera groups.Family Anaplasmataceae now contains four genera: Ehrlichia, Anaplasma, Neorickettsia, and Wolbachia.
42Ehrlichiosis and Anaplasmosis Small gram-negative bacteria that grow in membrane-bound vacuoles in leukocytes or plateletsTypically 1-3 um cocciDifferent species of Ehrlichia infect different types of host cellsNot all species transmitted by arthropodsHME (human monocytic ehrlichiosis), E. chaffeensisHGE (human granulocytic ehrlichiosis), (A. phagocytophila)HGE overlap with Lyme disease - both transmitted by Ix. scapularis complex members in US
43Ehrlichia chaffeensis is principally transmitted by the lone star tick (Amblyomma americanum). White-tailed deer are a major host of lone star ticks and appear to represent one natural reservoir for E. chaffeensis. Antibody to E. chaffeensis has been found throughout deer populations in the southeastern and midwestern United States, and the organism has been cultured from deer blood. (CDC)
44E. chaffeensis transmission (HME) Cases of HME are predominantly found in the South and south-central regions where the suspect vector, the Lone Star tick (Amblyomma americanum) is present.Amblyomma americanumLonestar tickAssociated withE. chaffeensis transmission (HME)
45Average annual incidence of reported human monocytic ehrlichiosis (HME) by county, using 1995 population census data.
46The HGE agent has been associated with the blacklegged tick (Ixodes scapularis) in the northeastern and upper midwestern United States. The western blacklegged tick (Ixodes pacificus) is a vector in northern California. Ixodes ricinus has been shown to be a vector of A. phagocytophila in Europe. Deer, elk, and wild rodents are likely reservoirs.
47Ixodes pacificus - western black-legged tick Cases of HGE have been reported primarily in the Northeast and Midwest regions and are associated with the bite of deer ticks (Ixodes scapularis). A few cases on the Pacific coast are associated with the related species, Ixodes pacificus.Ixodes scapularis - black-legged deer tick
48Average annual incidence of reported human granulocytic ehrlichiosis (HGE) by county, using 1995 population census data.
49Distribution of the Tick Vectors of Ehrlichia and Anaplasma in the United States
50Ehrlichiosis - Epidemiology During 1986 to 1997, health departments and other diagnostic laboratories reported over 1200 cases of human ehrlichiosis to CDC.Approximately two-thirds were cases of HME. CDC compiles the number of cases reported by the state health departments.Ehrlichiosis is a nationally notifiable disease; however, not all state health departments have reported cases of ehrlichiosis to CDC.
51Reported Cases of Ehrlichiosis in the United States
52Approximate Seasonal Distribution of HGE in the United States
53States where Ehrlichiosis is a notifiable disease (green)
54Lyme DiseaseLyme disease was named in 1977 when arthritis was observed in a cluster of children in and around Lyme, Connecticut.Other clinical symptoms and environmental conditions suggested that this was an infectious disease probably transmitted by an arthropod.Further investigation revealed that Lyme disease is caused by the spirochete bacterium, Borrelia burgdorferi.These bacteria are transmitted to humans by the bite of infected deer ticks and cause more than 16,000 infections in the United States each year.
55Lyme Disease - VectorsBlack-legged ticks (Ixodes scapularis) are responsible for transmitting Lyme disease bacteria to humans in the northeastern and north-central United States.On the Pacific Coast, the bacteria are transmitted to humans by the western black-legged tick (Ixodes pacificus).Ixodes ticks are much smaller than common dog and cattle ticks. In their larval and nymphal stages, they are no bigger than a pinhead.Ticks feed by inserting their mouths into the skin of a host and slowly take in blood.Ixodes ticks are most likely to transmit infection after feeding for two or more days.
60Lyme Disease - RiskIn the United States, Lyme disease is mostly localized to states in the northeastern, mid-Atlantic, and upper north-central regions, and to several counties in northwestern California.In 1999, 16,273 cases of Lyme disease were reported to the Centers for Disease Control and Prevention (CDC).Ninety-two percent of these were from the states of Connecticut, Rhode Island, New York, Pennsylvania, Delaware, New Jersey, Maryland, Massachusetts, and Wisconsin.Outdoor exposure - recreational, professional.
64Month of Lyme disease onset for reported cases, United States - 1992-1998.
65Lyme Disease - Symptoms Lyme disease most often presents with a characteristic "bull's-eye" rash, erythema migrans, accompanied by nonspecific symptoms such as fever, malaise, fatigue, headache, muscle aches (myalgia), and joint aches (arthralgia).The incubation period from infection to onset of erythema migrans is typically 7 to 14 days but may be as short as 3 days and as long as 30 days.Some infected individuals have no recognized illness (asymptomatic infection determined by serological testing), or manifest only non-specific symptoms such as fever, headache, fatigue, and myalgia.
67Lyme Disease - Treatment/Control Antibiotic treatment for 3-4 weeks with doxycycline or amoxicillin is generally effective in early disease.Cefuroxime axetil or erythromycin can be used for persons allergic to penicillin or who cannot take tetracyclines.Later disease, particularly with objective neurologic manifestations, may require treatment with intravenous ceftriaxone or penicillin for 4 weeks or more, depending on disease severity.In later disease, treatment failures may occur and retreatment may be necessary.
68BabesiosisBabesiosis is caused by hemoprotozoan parasites of the genus Babesia.While more than 100 species have been reported, only a few have been identified as causing human infections.Babesia microti and Babesia divergens have been identified in most human cases, but variants (considered different species) have been recently identified.Little is known about the occurrence of Babesia species in malaria-endemic areas where Babesia can easily be misdiagnosed as Plasmodium.
69Babesiosis - Life Cycle Babesiosis is transmitted by ixodid (hard-bodied) ticks. Ticks become infected by feeding on an infected vertebrate animal (rodents, cattle, wild animals) or transovarially (ticks thus can be vectors as well as reservoirs), depending on the Babesia species.In the ticks, the parasites develop and multiply. Transmission to the next vertebrate host occurs during a subsequent blood meal of the tick.Inside the vertebrate host, the parasites directly invade the erythrocytes (without the exo-erythrocytic liver stage required by human malaria parasites), where they undergo successive cycles of multiplication and reinvasion.The cycle is closed when the infected blood is ingested by a tick feeding on the mammalian host. Babesia can also be acquired by transfusion of blood or blood products.
70Babesiosis - Geographic Distribution Worldwide, but little is known about the prevalence of Babesia in malaria-endemic countries, where misdiagnosis as Plasmodium probably occurs.In Europe, most reported cases are due to B. divergens and occur in splenectomized patients.In the United States, B. microti is the agent most frequently identified (Northeast and Midwest), and can occur in non-splenectomized individuals.Two variants, arguably different species, have been reported in the U.S. states of Washington and California (WA1- type and related parasites) and Missouri (MO1).
72Rocky Mountain Spotted fever a. pathogen Rickettsia rickettsiib. Nearctic and Neotropical, first described in USc. human disease, now most common in eastern US, human encroachmentd. headache, lumbar ache, malaise, 2-5 day incubation, antibiotic treatmente. transmission by bite, trans-stadial and TOTf. D. variabilis eastern, D. andersoni western, Amblyomma cajennense neotropical
73Characteristic spotted rash of late-stage Rocky Mountain spotted fever on legs of a patient, ca. 1946
74Dermacentor andersoni Rocky Mountain wood tick Dermacentor variabilis American dog tick
75Figure 9. Reported cases of Rocky Mountain spotted fever in the United States,
76Figure 10. Seasonal distribution of reported cases of Rocky Mountain spotted fever,
77Figure 11. Number of reported cases of Rocky Mountain spotted fever by state and region,
78Tick-borne Viruses1. More than 100 arboviruses associated with ticks; 116 tick species, 32 argasid, 84 ixodid.2. Many based only on isolation of virus, disease potential unknown3. Most important all exist as zoonoses, and TOT occurs in some
79Colorado tick fever (Reoviridae, genus Orbivirus) a. focal zoonosis in Rocky Mountain states and South Dakota of US, and western Canada, overwinters in nymphb. main vector to humans is Dermacentor andersoni, no TOT, other zoonotic vectorsc. reservoir hosts - rodents, squirrels, porcupinesd. disease is dengue-like, 3-6 day incubation in humans, severe in children
80Tick-borne encephalitides (Flaviviridae, genus Flavivirus), two forms a. Russian Spring Summer encephalitis (far eastern form)I. taiga forest in E. Russia and NE ChinaII. vector is Ixodes persulcatusb. Tick-Borne encephalitis (western form)I. coniferous and temperate deciduous forestsII. vector is I. ricinusc. Overlap of tick species in western Russia, both forms of virus present, other ticks involved in focal transmission, TOT in ticks, "holiday" disease, tick bite or drinking milk of infected goat
81Kyasanur Forest disease (genus Flavivirus) a. Southern India, disease discovered following monkey deaths, and human illness/deathb. vector is Haemaphysalis spinigera (H. turturis - zoonotic cycle)c. human contact in forest, intrusion in foci of infectiond. fever, headache, severe muscle pain - diphasic - cough, GI disturbance, prolonged recovery, 5% mortality
82Crimean-Congo hemorrhagic fever (Bunyaviridae, genus Nairovirus)a. Russian states, Asia, Africa, Europe - first seen in Russian soldiersb. 27 tick taxa associated with zoonotic maintenance, TOT in some speciesc. human epidemics associated with Hyalomma marginatum and other sp. of Hyalommad. infection via bite, or crushing tick on skine. acute febrile illness with hemorrhagic symptoms
83Others: Louping Ill virus I. ricinus sheep, UK Omsk Hemorrhagic Fever virusDermacentor sp. and Ixodes sp. SiberiaPowassan Encephalitis virusDermacentor sp. and Ixodes sp. US
84MITESUsually less than 1 mm long, life cycle: egg-larva-nymph-adult, 1-3 nymphal stages1. oviposition - usually egg, but some ovoviviparous2. egg -- adult, 8 days to several weeks, average 4 weeksAbdomen joined to cephalothorax, no segmentation1. Typical 3 legs - larva, 4 legs - adult, but reduction in some species2. Chelicerae for tearing or piercing in parasitic species
85MITES Free-living, predaceous and parasitic - endo/ecto Skin damage to livestock, as much as $5 million /year in economic damageEffects on humans and animals:1. dermatitis or other tissue damage2. loss of blood or other tissue fluids3. transfer of pathogenic agents4. cause of strong allergic reactions
86ACARIASIS - infestation with mites Possible sites of infestation:external, inner and middle earrespiratory passages and lungsnasal passageslymphatic tissue
87(Laelaps sp., Ornithonyssus sp.) MITESOrder MesostigmataA. Relatively large mites, mm lengthB. Pair of stigmata located behind and lateral to third coxa, associated with peritremesC. Many are predatory, biocontrol usesD. Not host specific, human host unusual but will cause skin disorders(Laelaps sp., Ornithonyssus sp.)
89(Demodex sp., Trombiculid mites) Order ProstigmataA. Heterogenous group, weakly sclerotized, mm in lengthB. Stigmata present, usually at base of chelicerae, difficult to seeC. More than 50 families in suborder, some medically important(Demodex sp., Trombiculid mites)
93MITES - Control Sampling 1. Removal from outside host, with wash 2. Skin scraping for intradermal forms3. Drag similar to tick flagging
94MITES - Control Direct host treatment a. for human scabies, repeated treatments with ointments containing sulfur, benzyl benzoate, thiabendazole, or an approved insecticide (permethrin) - lindane resistanceb. injection of products such as Ivermectinc. insecticidal dipping for domestic animals
95MITES - Control Premise spray Repellent/Toxicant Quarantine a. spray roosts for chicken/fowl mitesRepellent/Toxicanta. permethrinb. apply to socks, bottom of pant legsQuarantine
97RickettsialpoxRickettsia akari Liponyssoides mite vectorHouse mice, rats - vertebrate hosts in urban areas
98ChiggersChiggers, also known as "redbugs, jiggers or harvest mites", are the immature stages of a tiny red mite.They inhabit areas of tall grass, associated with low, wet spots, ponds and stream banks, wild berry patches and forest underbrush.The larvae attach themselves to the clothing of people or to the fur of passing animals. Before settling down to feed, chiggers move to a constriction such as sock tops, waist bands or armpits.Feeding chiggers inject a salivary fluid which dissolves the host's cells, then suck up the liquefied tissue. Within a few hours, small, reddish, intensely itching welts appear.These bites may continue to itch for several days up to two weeks after the chigger is dislodged.
100US distribution of chiggers - other areas also have focally high populations The CulpritLarval chigger mite
101(Orientia tsutsugamushi) Scrub typhus(Orientia tsutsugamushi)Vector - larval Leptotrombidium mites\Reservoir - mites via TOT, transitory rodent infectionsDistribution - SE Asia and islands of Indian Ocean and SW Pacific, coastal North Queensland, AustraliaExposure - outdoor recreation or occupational exposure - disturbed habitat
103Chigger ProtectionStay out of areas where chiggers are likely to be present including woodlots, pastures, roadside ditches or other areas with tall grasses and weeds. Chiggers are especially common in moist low-lying areas.Wear loose-fitting clothing and avoid sitting or reclining on the ground when camping, picnicking or working outdoors.Apply a repellent containing DEET (N,N-diethyl-meta-toluamide) to shoes, socks and trousers before entering chigger-infested areas. Caution: some individuals may be sensitive to DEET. Always read and follow label directions.
104Chigger Protection - II Immediately after possible exposure to chiggers take a bath, thoroughly scrubbing the body with hot soapy water. This will kill or dislodge many of the chiggers.When bites begin to itch, apply rubbing alcohol, followed by one of the non-prescription local anesthetics. A baking soda paste, calamine lotion or product such as "After-Bite" also will help reduce discomfort.Avoid scratching bites since this only increases irritation and may lead to secondary infection of the bite.Where chiggers are a problem in landscapes, keep lawns and shrubbery well manicured especially in areas adjacent to dwellings. Eliminate tall grasses and weeds. Chiggers also can be reduced by spraying infested foliage with carbaryl (Sevin), chlorpyrifos (Dursban) or diazinon.
107ScabiesScabies is an infestation of the skin with the microscopic mite Sarcoptes scabei. Infestation is common, found worldwide, and affects people of all races and social classes.Scabies spreads rapidly under crowded conditions where there is frequent skin-to-skin contact between people, such as in hospitals, institutions, child-care facilities, and nursing homes.
108Scabies - SymptomsPimple-like irritations, burrows or rash of the skin, especially the webbing between the fingers; the skin folds on the wrist, elbow, or knee; the penis, the breast, or shoulder blades.Intense itching, especially at night and over most of the body.Sores on the body caused by scratching. These sores can sometimes become infected with bacteria.
109Scabies - InfestationBy direct, prolonged, skin-to-skin contact with a person already infested with scabies. Contact must be prolonged (a quick handshake or hug will usually not spread infestation). Infestation is easily spread to sexual partners and household members. Infestation may also occur by sharing clothing, towels, and bedding.People with weakened immune systems and the elderly are at risk for a more severe form of scabies, called Norwegian or crusted scabies.
115House Dust Mites - Dermatophagoides The term 'house dust mites' is used originally to refer to those mites belonging to Pyroglyphidae. At present, the term 'dust mites' is widely used instead and this is in reference to all pyroglyphid and nonpyroglyphidites that are implicated in dust borne respiratory allergy.House dust mites cause 25% of all allergies and 50% of all asthmatic diseases are traceable to house dust mites
117Ticks, Mites and Associated Pathogens Summary:Characteristics of the order Acari (ticks and mites)Metastigmatid mites = ticksMANY tick-borne pathogens…Mesostigmatid mites, prostigmatid mites and astigmatid mitesInfestation, allergy, scrub typhus, rickettsialpox