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Cellular response to DNA damage Reponse Mechanisms Tolerance of DNA damage Replicative bypass of template damage Translesion DNA synthesis Reversal.

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Presentation on theme: "Cellular response to DNA damage Reponse Mechanisms Tolerance of DNA damage Replicative bypass of template damage Translesion DNA synthesis Reversal."— Presentation transcript:

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3 Cellular response to DNA damage Reponse Mechanisms Tolerance of DNA damage Replicative bypass of template damage Translesion DNA synthesis Reversal of DNA damage Enzymatic photoreactivation Repair of O 6 -alkylguanine, O 4 - alkyltimidine Ligation of DNA strand breaks Excision of DNA damage Base Excision Repair Nucleotide Excision Repair Mismatch Repair Double strand breaks ligation Single strand annealing Recombinational Repair Non-Homologous End Joining

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7 La radiazione Solare può essere distinta in 3 componenti principali a seconda della lunghezza donda: ULTRAVIOLETTO ( nanometri) 10% VISIBILE ( nm.) 45% INFRAROSSO ( nm.) 45%

8 UV-induced damage

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10 UV-responsive photolyases

11 Direct reversal (de-alkylating proteins)

12 Base Excision Repair

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15 Nucleotide Excision Repair (E.coli)

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17 Nucleotide Excision Repair (Global Genome Repair -Humans)

18 Nucleotide Excision Repair (Transcription Coupled -Humans)

19 Common features of GGR & TCR

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