Presentation on theme: "Renal Pathology. Introduction: 150gm: each kidney 1700 liters of blood filtered 180 L of G. filtrate 1.5 L of urine / day. Kidney is a retro-peritoneal."— Presentation transcript:
Introduction: 150gm: each kidney 1700 liters of blood filtered 180 L of G. filtrate 1.5 L of urine / day. Kidney is a retro-peritoneal organ Blood supply: Renal Artery & Vein One half of kidney is sufficient – reserve kidney function: Filtration, Excretion, Secretion, Hormone synthesis.
Clinical Syndromes: Nephritic syndrome. –Oliguria, Haematuria, Proteinuria, Oedema. Nephrotic syndrome. –Gross proteinuria, hyperlipidemia, Acute renal failure –Oliguria, loss of Kidney function - within weeks Chronic renal failure. –Over months and years - Uremia
Introduction Functions of the kidney: –excretion of waste products –regulation of water/salt –maintenance of acid/base balance –secretion of hormones Diseases of the kidney –glomeruli –tubules –interstitium –vessels
Malignant nephrosclerosis Arises in malignant hypertension Hyperplastic vessels Ischemia of kidney Medical emergency
5% of cases of hypertension Super-high blood pressure, encephalopathy, heart abnormalities First sign often headache, scotomas Decreased blood flow to kidney leads to increased renin, which leads to increased BP! 5y survival: 50% Malignant Hypertension