1. Applied Mathematics –Computational Engine Research – F. Tanner –Simulation of Food Sprays – F. Tanner –Multiphase Fluid Systems – K. Feigl –Cardiac Dynamics – W. Ying Statistical Genetics Group –Q. Sha, R. Jiang, J. Dong, S. Zhang, H. Chen Department of Mathematical Sciences March 2008Computing Initiative

2. Motivation –Health and Environmental –Sustainability Main Objectives –Understand physical processes –Develop simulation tools Results –Strategy to minimize fuel consumption and emissions –Multi-orifice asynchronous injection Computational Engine Research Mass fraction of an evaporating fuel spray March 2008Computing Initiative

3. Motivation –Spray-drying and spray-freezing –Encapsulation of nutrients Main Objectives –Obtain desired drop size distributions –Maximize production Modeling Challenges/Research –Complex flows and materials –Phase changes Modeling of Food Sprays Air-assisted atomization of a nutriose liquid spray March 2008Computing Initiative

4. Examples/Applications –Emulsions, foams, polymer blends –Foods, plastics, pharmaceuticals Goals –Understand process- microstructure- rheology relationship –Design processes to optimize product properties Research –Multidisciplinary approach –Combine modeling, simulation and experiments Simulation of Fluid Systems Simulated deformation of a fluid droplet March 2008Computing Initiative

5. Droplet deforming in supercritical shear flow Droplet deforming in supercritical elongational flow March 2008Computing Initiative Simulation of Fluid Systems

6. Wenjun Ying –Ph.D. Math – Duke University –Post-doc – Biomedical Eng. – Duke University Modeling electrical dynamics in the heart using adaptive meshes Simulation of Cardiac Dynamics Simulation of Dog Heart March 2008Computing Initiative

7. Sixteen Members –5 faculty –2 post-docs –9 PhD Students Supported by 4 NIH Grants Total funding of over $1 million Statistical Genetics Group March 2008Computing Initiative

8. Group Aims –Develop new tools for analysis of genomic data –Use innovative models and methods in human genetic studies Key Research Areas –Functional gene mapping –Pedigree analysis –Gene interactions –Computational methodologies –Microarray analysis March 2008Computing Initiative Statistical Genetics Group