Presentation on theme: "Crohn’s disease - A Review of Symptoms and Treatment"— Presentation transcript:
1 Crohn’s disease - A Review of Symptoms and Treatment Brian NguyenUniversity of California - Irvine Medical Center, Orange, CA
2 Background Inflammatory bowel disease in large intestine and rectum May occur in any part of GI tractChronic conditionOnset occurs yrs oldExact cause unknownGenetic risk factorsPeople who have relative with the disease have risk factor 10x greater than general population. Brother or sister, 30x greater.
3 Background Autoimmune disorder Immune system attacks normal microbes White blood cells rush liningChronic inflammationSimilar symptoms to ulcerative colitisUC affects superficial layers and colon onlyCD affects all layers and GI tract
4 Usually found in ileocecal region (small intestine to large intestine) Ileum to cecumUsually found in ileocecal region (small intestine to large intestine)
6 Symptoms Periods of flare ups Abdominal pain Diarrhea Fever Weight lossAnal pain
7 Complications Obstruction of bowel Ulcers in tract Malnutrition Swelling or scar tissueUlcers in tractCan result in fistulas (30%)AbscessMalnutritionInadequate intake and absorption
8 Diagnosis Colonoscopy (70% effective) Radiological studies Blood tests Visualization of colon and terminal ileumRadiological studiesCan help see remainder of small intestineHighlights inflammationBlood testsAnemia indication for Crohn’sInflammation of small intestine can be seen with narrowing of the intestine and prevention of passage of stool and air
9 Treatment No “cure” – only symptom relief Medication Surgery Cortisteroids or anti-inflammatory agentsImmunosuppressive drugsSurgeryRemove diseased portion of intestineAnastomosis connects remaining bowel50% patients have recurrence within 5 yearsAntibiotics to treat infectionsIndications for surgery include hemorrhage, fistulas, abscesses or strictures. Surgery needed for about ¾ of patients. Usually total abdominal colectomy or total proctolectomy with ileostomy performed.
10 SurgeryTotal proctolectomyTotal proctocolectomy with ileostomy
11 SurgeryTotal colectomy with ileorectal anastomosis
12 Prognosis No cure Higher risk for colon cancer Long periods of remission