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Per ordine alfabetico Consumer Health Databases ClinicalTrials.gov, MEDLINEplusClinicalTrials.govMEDLINEplus Databases about AIDS AIDS Information.

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Presentation on theme: "Per ordine alfabetico Consumer Health Databases ClinicalTrials.gov, MEDLINEplusClinicalTrials.govMEDLINEplus Databases about AIDS AIDS Information."— Presentation transcript:

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5 Per ordine alfabetico

6 Consumer Health Databases ClinicalTrials.gov, MEDLINEplusClinicalTrials.govMEDLINEplus Databases about AIDS AIDS Information Resources, AIDSLINE, AIDSTRIALS and AIDSDRUGSAIDS Information ResourcesAIDSLINEAIDSTRIALS and AIDSDRUGS Databases about Chemicals and Toxicology Chemical Carcinogenesis Research Information System, ChemID, ChemIDplus, Developmental and Reproductive Toxicology Database, EMIC, Gene-Tox Program of the U.S. Environmental Protection Agency, Integrated Risk Information System, Toxic Chemical Release Inventory, Toxicology Data Network, TEHIP, TOXLINEChemical Carcinogenesis Research Information SystemChemIDChemIDplusDevelopmental and Reproductive Toxicology DatabaseEMICGene-Tox Program of the U.S. Environmental Protection AgencyIntegrated Risk Information SystemToxic Chemical Release Inventory Toxicology Data NetworkTEHIPTOXLINE Databases about Genetics Human Genome Resources, Entrez Molecular Sequence Database System, GenBank Retrieval and Sequence Similarity Searching by Internet Electronic Mail, Nat'l Center for Biotechnology Information, Submitting Data to GenBankHuman Genome ResourcesEntrez Molecular Sequence Database SystemGenBank Retrieval and Sequence Similarity Searching by Internet Electronic Mail, Nat'l Center for Biotechnology InformationSubmitting Data to GenBank Databases about Health Services Research, HealthSTAR (incorporates Health Planning & Administration and HSTAR Databases), Health Services Research Projects in Progress, Health Services/Technology Assessment Texts (HSTAT)HealthSTARHealth Services Research Projects in ProgressHealth Services/Technology Assessment Texts (HSTAT) NLM Image Databases, Images from the History of Medicine on Internet, Visible Human ProjectImages from the History of Medicine on InternetVisible Human Project Other Specific NLM Databases DIRLINE, DOCLINE, HISTLINE, SERHOLDDIRLINEDOCLINEHISTLINESERHOLD NLM DATABASES

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8 Clinicaltrials.gov Per chi: pazienti e familiari, media ma anche medici Quali informazioni: abstract dei protocolli (obiettivi, stato di reclutamento, criteri per reclutamento e partecipazione, contact info), informazioni aggiuntive (study design, fase del trial, malattia in studio) Quando è stato fatto: in seguito a atto dellFDA del 1997 registro degli studi finanziati da NIH e enti privati su trattamento sperimentale della malattie gravi e/o con rischio di vita Status: non richiede registrazione. Recensisce oltre 5200 studi sponsorizzati da NIH. Studi sponsorizzati da industria privata saranno aggiunti nel 2000-2001.

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16 Descrive in maniera schematica i dettagli dello studio

17 Criteri di inclusione ed esclusione

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20 Premesse e razionale

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22 Clinical trials: Resource information Understanding clinical trials Informations about specific types of clinical trials (cancer trials, vision research..) NIH Clinical Alerts Information about drugs (recently approved, electronic orange book) General health information (Medline plus, FDA consumer magazine, NIH health info) Related information

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26 Trial interrotto per chiara dimostrazione di inefficacia

27 Suggerimento clinico

28 Farmaci di recente approvazione

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30 Farmaci di recente approvazione: scheda tecnica

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40 About HSDB HSDB contains over 4500 chemical records, each of which can have as many as 150 or so fields of data. HSDB's road scope covers human and animal toxicity, safety and handling, environmental fate, and more. HSDB data undergoes a high level of peer review by the HSDB Scientific Review Panel. HSDB contains one record per chemical.

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45 Dati dellEPA su human risk assessment, focus su dose response

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47 CCRIS: dati di carcinogenesi, mutagenesi, e inibizione della crescita tumorale dal NCI Chemical Carcinogenesis Research Information

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49 About GENE-TOX GENE-TOX is created by the U.S. Environmental Protection Agency (EPA) and contains genetic toxicology (mutagenicity) test data, resulting from expert peer review of the open scientific literature, on some 3000 chemicals. The GENE-TOX program was established to select assay systems for evaluation, review data in the scientific literature, and recommend proper testing protocols and evaluation procedures for these systems. Each of TOXNET's toxicology data files (HSDB, IRIS, CCRIS, and GENE-TOX) contains one record per chemical.

50 GENE-TOX: dati di genotossicità sottoposti a peer review dallEPA

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52 Database di letteratura tossicologica TOXLINE: database mirato su efetti biochimici, farmacologici, fisiologici e tossicologici di farmaci e composti chimici EMIC: Environmental Mutagen Information Center: letteratura corrente su agenti testati per attività genotossica DART/ETIC: Developmental and Reproductive Toxicology and Environmental Teratology Information Center: dati di tossicologia della riproduzione e dello sviluppo

53 About DART The Developmental and Reproductive Toxicology (DART) database consists of citations to literature on chemical, physical, and biological agents that may cause birth defects. It contains citations to literature published since 1989. Approximately 60 percent of DART is derived from MEDLINE.

54 Database di interesse ambientale TRI: Toxic Release Information: report dallanno 1995 dallEPA sul rilascio ambientale di sostanze tossiche

55 Database di Informazione Chimica e Biochimica ChemIDplus: informazioni su sinonimi, struttura e link ad altri database contenenti informazioni su sostanze chimiche e farmaci HSDB Structures: informazioni sulla struttura bidimensionale dei composti presenti nel data base HSDB (hazardous Substances DB) NCI-3D: informazioni sulla struttura 2D e 3D a cura del National Cancer Institute


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