Presentation is loading. Please wait.

Presentation is loading. Please wait.

Fragmentation experiments Fragmentation experiments LNS LNS Status Report C.Agodi TPS collaboration meeting Torino 5-6 novembre 2009.

Similar presentations

Presentation on theme: "Fragmentation experiments Fragmentation experiments LNS LNS Status Report C.Agodi TPS collaboration meeting Torino 5-6 novembre 2009."— Presentation transcript:

1 Fragmentation experiments Fragmentation experiments LNS LNS Status Report C.Agodi TPS collaboration meeting Torino 5-6 novembre 2009

2 What is the contribution to Ion Therapy Treatment Planning ? The optimal TPS should be interactive and evaluated in real time. Innovative contribution in this field is particularly needed in case of clinical ions beams. Energy losses can be assessed via Monte Carlo simulation mainly to account for fragmentation nuclear processes. Cross section fragmentation data RBE table remodels the physical dose deposition including the hadron specificity Cross section fragmentation data LNS LNS The Treatment Planning Systems (TPS) is a complex computer system that helps both to design radiation treatments and to compute the dose to the patient. Planning Treatment Volume Computed Tomography

3 Projectile fragmentation Reaction products : have velocity near to the primary beam; are emitted mostly in the forward direction The detection system has to be efficient in the interest angular region LNS LNS Projectile Reaction at Intermediate energy Target Nuclei Fragmentation

4 12 C beam from CS Target Hodo Big Hodo small LNS LNS Our Measurements at LNS: The Experiment We already measured the 12 C fragmentation on 197 Au and 12 C targets with 32 and 62 AMeV CS beams at LNS-INFN, Catania In 2010 we plan to use different beams up to 80 AMeV. INFN Laboratory Nazionali del Sud, Catania - Sicily - Italy Superconducting cyclotron LNS – INFN, Catania An hodoscope (hodo big and hodo small) composed of two-fold and three- fold telescopes has been used for identify fragments produced in the reaction and measure the energy (θ lab between 0° and ±20°) LNS LNS

5 HODO-BIG: 89 three-folds telescopes array 4.5°-22.5° Si(50μm)-Si(300μm)-CsI(6cm) HODO-SMALL: 81 two-folds telescopes array 4.5°-4.5° Si(300μm)-CsI(10cm) projectile fragment Experimental set – up LNS LNS

6 FRAG (April 2009) 12 C+ 12 C, 197 C + C N° 5·10 12 I ~ 40 – 80 pA C + CH 2 N° 1·10 12 I ~ 40 – 60 pA C + AuN° 11·10 12 I ~ 180 – 230 pA LNS LNS

7 E-E plot LNS LNS

8 Measured vs calculated angular differential cross sections

9 CHARGED PARTICLE PRODUCTION CROSS SECTION PRELIMINARY COMPARISONS – LNS DATA AT 62 AMeV Carbon incident General better agreement of JQMD with our modifications but still worse agreement in the intermediate part of the spectra LNS LNS

10 Extensive study of nuclear reactions of interest for medical and space applications. G.Cuttone, F.Marchetto, G.Raciti, E.Iarocci, V.Patera, C.Agodi, C.Sfienti, E.Rapisarda, M. De Napoli, F. Giacoppo, M.C. Morone, A. Sciubba, G.Battistoni, P.Sala, Sacchi, E.Spiriti, G.A.P.Cirrone, F.Romano INFN: LNS, LNF, Roma2, Roma3, Milan, Turin, Roma Tor Vergata S.Leray, M.D. Salsac, A.Boudard, J.E. Ducret, M. Labalme, F. Haas, C. Ray DSM/IRFU/SPhN CEA Saclay, IN2P3 Caen, Strasbourg, Lyon M. Durante, D. Schardt, R. Pleskac, T. Aumann, C. Scheidenberger, A. Kelic, M.V.Ricciardi, K.Boretzky, M. Heil, H. Simon, M. Winkler GSI P. Nieminen, G. Santin ESA Proposal of Experiment at SIS LNS LNS

11 GSI-GPAC: «Extensive study of nuclear reactions of interest for Medical and Space Applications»: S371 LNS LNS

12 Assuming that the dependence of the acceptance on Pt can be determined with a 20% error then all the slopes should be determined with an accuracy better than 2.5 %, in the worst case (Z = 2) We can get the goal of 3% error in Double Differential Cross Section Estimation of the systematic errors on momentum and angle as reconstructed with ALADIN

13 Fragmentation measurements at GSI The G-PAC approved with high priority the key measurements: LNS LNS 0.2, 0.4 and 1.0 AGeV 0.2, 0.4 AGeV 0.2, 0.4 AGeV

14 Hadrotherapy Analysis Exp.Apr.09 (deadline proposal 12/09) Fragmentation 2010 LNS LNS

15 12 C Fragmentation measurements In order to perform a systematic study of projectile fragmentation intermediate energies, we measured the 12 C fragmentation cross section on different targets at 32 and 62 AMeV at LNS. LNS LNS New mixed inner radiation field ! New mixed inner radiation field ! projectile target projectile fragment target fragment Outer radiation fields Interaction of the radiation with the spacecraft hulls, the body... Target Fragments Projectile fragments … lower charge… lower charge … lower charge … lower charge than target than primaries than target than primaries … high LET … mixed LET … short ranges … long ranges

16 Sezione durto di produzione di particelle cariche ( particelle α) CONFRONTO PRELIMINARE – DATI LNS ( 12 C at 62 AMeV) In generale miglior accordo con il JQMD con le nostre modifiche. Resta comunque una discrepanza notevole nella parte intermedia dello spettro LNS LNS

17 Why fragmentation measurement in hadrontherapy? Disadvantages LNS LNS Light ions Advantages Better Spatial selectivity in dose deposition: Bragg Peak Reduced lateral and longitudinal diffusion High Conformal dose deposition High Biological effectiveness Treatment of highly radiation resistent tumours, sparing surrounding OAR Fall of dose in the tumour target region Unwanted dose in normal tissue behind the target volume An extensive database on nuclear fragmentation cross sections and fluences are needed at therapeutic energy region

18 Disadvantages of carbon ions Nuclear Fragmentation of 12 C beam in the interaction processes with: energy degraders, biological tissues Further problem different biological effectiveness of the fragments Mitigation and attenuation of the primary beam Dose over the Bragg Peak : p ~ 1-2 % C ~ 15 % Ne ~ 30 % Production of fragments with higher range vs primary ions LNS LNS

19 Carbon ions advantages Lower lateral and longitudinal diffusion vs. proton More precise energy deposition Optimal RBE profile - penetration depth position. Online PET for depth deposition monitoring Good Compromise between RBE and OER. LNS LNS

20 Our Measurements at LNS: The Experiment The Hodo-small, set up at a distance of 80 cm from the target consisted of 81 two- fold telescopes: 300 µm Silicon detectors 1x1 cm 2 of active area followed by a 1x1 cm 2 and 10 cm long CsI(Tl) and covered the angular range θ lab =±4.5°. The Hodo-big, set up at a distance of 0.6 m from the target, consisted of 89 three- fold telescopes 50 µm µm Silicon detectors both having 3x3 cm 2 surface followed by a 6 cm long CsI(Tl)of the same surface. It covered the angular range θ lab between ±4.5° and ±20° Hodo Small Target Hodo Big E CsI(Tl)

Download ppt "Fragmentation experiments Fragmentation experiments LNS LNS Status Report C.Agodi TPS collaboration meeting Torino 5-6 novembre 2009."

Similar presentations

Ads by Google