1. UPDATE ON EMERGENCY CARDIAC CARE GUIDELINES Mark L. Greenberg, MD Associate Professor of Medicine Director, Clinical Electrophysiology and Pacing

2. 1 BLS and ACLS-- Historical Perspective l 1956: External defibrillation (Zoll) l 1958: Mouth-to-mouth ventilation (Safar, Elam) l 1960: Chest compressions (Kouwenhoven) l 1979: Automatic External Defibrillator (AED) (Diack) l 1996: Biphasic waveform approved for AED use in USA l 2000: First international evidence-based resuscitation guidelines

3. The Chain of Survival of Cardiopulmonary Resuscitation

4. Valenzuela, et al. Circulation. 1997;96:3308- 13. Interdependence of Early CPR and Early Defibrillation

5. The physiologic mechanism of chest compressions: cardiac pump (A) or thoracic pump (B)?

6. What’s New in BLS l New Chest Compression Rate and Compression- Ventilation Ratio for Adults l Interposed Abdominal Compression CPR (IAC- CPR)

7. INTERRUPTIONS IN CHEST COMPRESSIONS ARE DETRIMENTAL l Lay rescuers: 16 seconds to administer 2 breaths (cf 3-4 sec. for professionals). l Compression: ventilation ratio of 5:1 yields higher PaO2 but lower oxygen delivery than 15:2 (64 compressions, 8 ventilations per minute).

8. New Chest Compression Rate and Compression-Ventilation Ratio for Adults l Compression rate approx. 100/min for adults and children over age one l Compression-ventilation ratio 15:2 for both one and two-rescuer CPR (5:1 after trachea intubated)

9. Interposed Abdominal Compression CPR (IAC- CPR) l An alternative for in-hospital resuscitation l Abdomen compressed between xiphoid and umbilicus during relaxation phase of chest compression l Increases forward blood flow during CPR and appears to improve survival

10. IAC-CPR

11. Seesaw-like Function of the Lifestick

12. ResQPump™ Metronome Force Gauge Handle Suction Cup

13. Inspiratory Impedance Threshold Valve (ITV) l Design: Each time the chest wall recoils following a compression, the ITV transiently blocks air/oxygen from entering the lungs, creating a small vacuum in the chest. l Concept: Lower intrathoracic pressure in the chest during the decompression phase of CPR enhances venous return to the thorax.

14. ResQValve  (CPR x ) Disposable, one- way valve that fits into the respiratory circuit and impedes inspiratory gas exchange during decompression

15. ResQValve Placement

16. BrainLeft Ventricle STD CPR STD CPR + ITV ACD CPR ACD CPR + ITV 0.0 0.2 0.4 0.6 0.8 1.0 Blood Flow During CPR (Porcine VF Model) Blood Flow (ml/min/gm) Lurie et al. Improving ACD CPR with an inspiratory impedance valve. Circulation 1995;91:1629-32.

17. Blood Pressure During CPR in Humans 0 20 40 60 80 100 120 mmHg Systolic Diastolic STD CPR ACD + ITV Cohen et al, JAMA 1992 and Plaisance et al, Circulation 2000 Baseline (Normal)

18. RCT of ACD/ITV CPR vs. STANDARD CPR l 220 patients, 157 with witnessed events (Mainz, Germany) l 24 hr. survival 37% with ACD/ITV CPR vs. 22% with standard CPR (p=0.03) Wolcke et. al. Circulation.2002;106:II-538.

19. What’s New in External Defibrillation l More emphasis on early defibrillation l Automatic External Defibrillation (AED) and Public Access Defibrillation (PAD) l Defibrillation with a biphasic waveform

20. Defibrillation The Time Factor* Survival rates after VF cardiac arrest decrease approximately 7% to 10% with every minute that defibrillation is delayed. Guidelines 2000 for Cardiovascular Resuscitation and Emergency Cardiovascular Care.Circulation. 2000;102(suppl I)8. August 22,2000 Time (min) 100 80 90 70 60 50 40 30 20 10 0 1 2345678 9 Percent of Survival 10 * Non-linear

21. 13 year old boy struck by a pitch Commotio Cordis

22. Goals For Early Defibrillation l In hospital: defibrillation within 3 minutes l Out of hospital: defibrillation within 5 minutes of activation of the EMS (value of AED and PAD)

24. Unconscious patient, no pulse Shock advised

25. Unconscious patient, no pulse No shock advised?

26. President Bill Clinton, 5/20/00 radio address. “It is time for the national government to help bring AED’s to public places all over America... I am working with Congress to complete a vital piece of legislation that would not only encourage the installation of AED’s in federal buildings, but also grant legal immunity to good Samaritans who use them... It is now our responsibility to bring this technology, this modern miracle, to every community in America.”

27. Prevalence of AED’s l National Registry of CPR Hospitals: 31% l VA Hospitals: 14% l Commerical Airliners: 100%

28. O’Hare International Airport: 60-90 Second Walk To An AED Caffrey et. al. N Engl J Med 2002;347:1242-7.

29. CHICAGO AIRPORT AED STUDY l Three airports, serving >100 million passengers/yr. l 21 cardiac arrests over 2 yrs; 18 had VF, 11 of whom were resuscitated (10 alive & well one yr. later) Caffrey et. al. N Engl J Med 2002;347:1242-7.

30. Incidence of Unexpected Cardiac Arrest

32. AEDs: UNANSWERED QUESTIONS l Does formal training improve performance? l How are they best deployed? l Are they cost effective?

33. DEFIBRILLATOR WAVEFORMS

34. Defibrillation Current Flow l Biphasic defibrillation—current flows in two phases, first in one direction from one electrode, and then current flows the other way from the other electrode

35. Biphasic Defibrillation Risk of Damage Source: SL Higgins, Prehospital Emergency Care 2000; 4:305-313 Much less peak current and better efficacy than monophasic Biphasic Peak Current Monophasic Peak Current 40% Difference -20 -10 0 10 20 30 40 05101520 Time (msec) Current (amps)

36. Transthoracic Impedance l Measured by the defibrillator l Higher impedance Skin surface—especially dry Hair Fat Bone Air in chest

37. Impedance The current a heart receives from a 200J shock depends on the patient’s impedance 0 10 20 30 40 50 60 255075100125150 Patient Impedance (ohms) Peak Current (amps) Current variance due to impedance, energy held constant

38. Impedance Distribution 3040506070 80 90100110120130140150More 0 2 4 6 8 10 12 14 16 Histogram of patient impedances Impedance (ohms ) Percentage of Patients Medtronic Physio-Control: Impedance data on 723 SCA patients.

39. Biphasic Defibrillators Are NOT All the Same l Waveforms vary (with regard to voltage or pulse duration) in their response to transthoracic impedance measurements. l Energy settings may be fixed, low- dose escalating, or “standard” dose escalating. l No clear superiority among manufacturers.

40. IMPEDANCE ADJUSTMENT WITH PHILIPS FR2 50 40 30 20 10 0 -10 -20 0 5 10 152025303540 Current (A) Time (msec) SMART Biphasic l 150-150-150 J l Current adjusted for impedance l Customized waveform shape for each patient and each shock 50 , 150 J 75 , 150 J 125 , 150 J

41. Why Will Biphasic Defibrillators Replace Standard Monophasic Models? l Impedance compensating, lower shock strength biphasic waveforms have less potential to damage cells. l Biphasic waveforms have superior efficacy for treating atrial fibrillation and ventricular fibrillation.

42. Randomized, controlled trial of 150 J biphasic shocks with 200-360 J monophasic shocks in 115 patients with out-of-hospital VF; time to first shock 8.9+/-3.0 min.. 1st shock % Biphasic Monophasic p <0.0001 96% (52/54) 59% (36/61)B 3 shocks Biphasic Monophasic p < 0.0001 98% (53/54) 69% (42/61) Schneider T, et al, Circulation 2000;102:1780-1787.

43. What’s New in ACLS? l Airway Management l Vasopressin l IV amiodarone as a first-line drug

44. What’s New in Airway Management l Emphasis on skilled bag-mask ventilation with continuous cricoid pressure l Validation of airway adjuncts like the laryngeal mask and Combitube l Recommendation for secondary confirmation techniques to verify ETT placement (e.g.end-tidal CO2)

45. Cricoid Pressure Can Minimize Gastric Inflation

46. Advanced Airway Devices l Esophageal- tracheal combitube

47. Advanced Airway Devices l Laryngeal mask airway (LMA) l Superior to ETT for BLS-level personnel l Equal to ETT for ACLS-level personnel

48. Laryngeal Mask

49. Confirming Tracheal Tube Placement Esophageal detector devices

50. Vasopressin 40 U IV Before Epinephrine 1 mg IV? l Vasopressin appears at least as effective as epinephrine (large RCT underway in Europe). l Vasopressin is non-beta-adrenergic and does not increase myocardial 02 consumption. l Longer half-life (10-20 min. vs. 3-5 min.) simplifies administration.

51. Amiodarone 300 mg IV Should Be Given Before Lidocaine l Advantage lidocaine: rapid onset of action, no hypotension l Game, set, and match amiodarone: minimal proarrhythmia, much stronger evidence for efficacy

52. Kudenchuk et. al. NEJM 1999;341:871-8. Amiodarone vs. Placebo in 504 Pts. with Shock Refractory Out- of-Hospital VT/VF

53. Amiodarone vs. Lidocaine for Shock-Resistant VF Dorian et al. N Engl J Med 2002;346:884-90.

54. Stable Ventricular Tachycardia

55. Polymorphic Ventricular Tachycardia