Presentation on theme: "HIV Structure, Lifecycle, and Replication"— Presentation transcript:
1 HIV Structure, Lifecycle, and Replication Background: Basic VirologyStructure: Virion structure, genome,and proteinsLifecycle: Infection and Expression
2 VirusesMicroscopic infectious agents that can infect the cells of a biological organism.Viruses can only replicate themselves by infecting a host cell and are incapable to reproduce on their own.A complete virus particle, known as a virion consists of nucleic acid surrounded by a protective coat of protein called a capsid.
3 Human immunodeficiency virus (HIV) is a retrovirus that causes acquired immunodeficiency syndrome (AIDS).HIV primarily infects vital cells in the human immune system such as helper T cells (CD4+ T cells), macrophages and dendritic cells. HIV infection leads to low levels of CD4+ T cells.
36 Some Take-home points: HIV Structure:HIV is comprised of viral proteins, host cell membraneenv is the only exposed viral protein (evades immune response)gag (p24) represents the primary structural component of virion
37 Take-home points: HIV Genome: RNA genome -- requires HIV reverse transcription to DNAIn a productive infection, genome permanently integrates into host genomeHIV Genome encodes 9 viral genes: 3 structural, 3 regulatory, 3 accessory
38 Discussion Points/Exercises Can you draw a representation of what HIV looks like?Explain, in general lay terms in 1 sentence, how an HIV entry inhibitor, reverse transcriptase inhibitor, integrase inhibitor, and protease inhibitor work based on your knowledge of the HIV lifecycle.Discuss where you think other targets for antiretroviral therapy may be based on its lifecycle.