1. PREMENSTRUAL SYNDROME Ozgul Muneyyirci-Delale

2. Premenstrual Syndrome Premenstrual Syndrome (PMS) is defined as “the cyclic recurrence in the luteal phase of the menstrual cycle of a combination of distressing physical, psychological, and/or behavioral changes of sufficient severity to result in deterioration of interpersonal relationships and/or interference with normal activities. Nearly 200 symptoms have been associated with this definition and it is the clustering of these signs and symptoms that is the hallmark of PMS.

3. Catamenial The term “catamenial” is derived from the Greek and signifies around menses. In general an instance where a single recognized medical condition presented in the premenstruum was referred to as a catamenial disorder while a cluster of symptoms was referred to as PMS.

4. Premenstrual Magnification Many patients with psychiatric disorders also complain of worsening of their symptoms around the premenstrual phase, called “premenstrual magnification” (PMM).

5. PMS Milder symptoms are believed to occur in about 30% to 80% of reproductive-age women, while severe symptoms are estimated to occur in 3% to 5% of menstruating women.

6. Concordance Rate The concordance rate (if both twins have PMS) was found to be significantly higher in monozygous twins (93%) than dizygous twins (44%) and in non-twin control women (31%).

8. Common Symptoms of PMS Women with PMS Symptom Showing Symptoms (%) Behavioral Fatigue92 Irritability91 Labile mood with alternating sadness and anger81 Depression80 Oversensitivity69 Crying spells65 Social withdrawal65 Forgetfulness56 Difficulty concentrating 47

9. Common Symptoms of PMS (Continued) Physical Abdominal bloating90 Breast tenderness85 Acne71 Appetite changes and food cravings70 Swelling of the extremities67 Headache60 Gastrointestinal upset48

10. Differences Between PMS and PMDD

11. Differences Between PMS and PMDD (Continued)

12. Patterns of PMS  Premenstrual symptoms can begin at ovulation with gradual worsening of symptoms during the luteal phase (pattern 1).  PMS can begin during the second week of the luteal phase (pattern 2).

13. Patterns of PMS (Continued)  Some women experience a brief, time-limited episode of symptoms at ovulation, followed by symptom-free days and a recurrence of premenstrual symptoms late in the luteal phase (pattern 3).  The most severely affected women have symptoms that at ovulation worsen across the luteal phase and remit only after menses cease (pattern 4). These women describe having only one week a month that is symptom-free.

14. Differential Diagnosis Psychiatric disorders  Major depression  Dysthymia  Generalized anxiety  Panic disorder  Bipolar illness (mood irritability)  Other Medical disorders  Anemia  Autoimmune disorders  Hypothyroidism  Diabetes  Seizure disorders  Endometriosis  Chronic fatigue syndrome  Collagen vascular disease

15. Differential Diagnosis (Continued) Premenstrual exacerbation  Of psychiatric disorders  Of seizure disorders  Of endocrine disorders  Of cancer  Of systemic lupus erythematosus  Of anemia  Of endometriosis Psychosocial spectrum  Past history of sexual abuse  Past, present, or current domestic violence

16. Diagnosis of PMS PMS A.Does not meet DSM-IV criteria but does meet ICD-10 criteria for PMS B. Symptoms occur only in the luteal phase, peak shortly before menses, and cease with menstrual flow or soon after C. Presence of one or more of the following symptoms  Mild psychological discomfort  Bloating and weight gain  Breast tenderness  Swelling of hands and feet  Aches and pains  Poor concentration  Sleep disturbance  Change in appetite

17. PMDD (DMS-IV Criteria) A.At least five of the symptoms below, with at least one being a core symptom, are present a week before menses and remit a few days after onset of menses:  Depressed mood or dysphoria (core symptom)  Anxiety or tension (core symptom)  Affective lability (core symptom)  Irritability (core symptom)  Decreased interest in usual activities

18. PMDD (DMS-IV Criteria) (Continued)  Concentration difficulties  Marked lack of energy  Marked change in appetite, overeating, or food cravings  Hypersomnia or insomnia  Feeling overwhelmed  Other physical symptoms (e.g., breast tenderness, bloating, headache, joint or muscle pain)

19. PMDD (DMS-IV Criteria) (Continued) B.Symptoms must interfere with work, school, usual activities, or relationships C.Symptoms must not merely be an exacerbation of D.Criteria A, B and C must be confirmed by prospective daily ratings for at least two cycles

20. See Attached Menstrual Symptom Diary

21. Treatment of PMS  Oral contraceptives  Vitamin B 6  Bromocriptine  Monoamine oxidase inhibitors  Synthetic progestational agents  Spironolactone  Massage therapy  Chiropractic therapy  Calcium

22. Treatment of PMS (Continued)  Primrose oil  Prostaglandin synthesis inhibitors  Medical and surgical oophorectomy  Alprazolam (Xanax)  Naltrexone: opiate antagonist  Fluxetine (Prozac)

24. With a placebo response rate in patients with PMS ranging between 20% and 50%, it is essential that double-blind, randomized trials be conducted to assess therapeutic effectiveness.