1. Leukosan® SkinLink | Bridging the gaps in wound closure Leukosan ® SkinLink Clinical Case Documentation

2. Leukosan® SkinLink | Bridging the gaps in wound closure Content Dermatology and Venerology Accident Surgery Obstetrics and Gynaecology Oral and Maxillofacial General and Visceral Surgery Otolaryngology (ENT) / Head and Neck Surgery Paediatric Surgery Plastic Surgery Orthopaedics Emergency Room

3. Leukosan® SkinLink | Bridging the gaps in wound closure Ankle Fracture Day of Surgery Day 4, post SurgeryDay 14, post Surgery Patient Age:22 Sex:male Wound Type of Wound:Surgical incision due to distal ankle fracture Length of Wound:approximately 10 cm Treatment Hospital:University of Rostock, Germany date:16.04.2006 Surgeon/ Doctor:Dr. Helms/Prof. Dr. Mittlmeier Type of Treatment: Plate osteosynthesis Wound closure:SkinLink (6 closures, size large) plus subcutaneous sutures Wound healing No complications; SkinLink closures were removed on day 14 post surgery; Patient and surgeon were highly satisfied as regards application, wound closure performance, healing status and wearing comfort. Accident Surgery

4. Leukosan® SkinLink | Bridging the gaps in wound closure Radius Fracture Day 4, post Surgery Day 16, post Surgery Additional follow up Patient Age:74 Sex:female Wound Type of Wound:Surgical incision due to distal radius fracture Length of Wound:approximately 7 cm Treatment Hospital:University of Rostock, Germany date:08.06.2006 Surgeon/ Doctor:Dr. Helms/Prof. Dr. Mittlmeier Type of Treatment:Plate osteosynthesis Wound closure:SkinLink (7 closures, size small) plus subcutaneous sutures Wound healing SkinLink closures were removed on day 13 post surgery; healing process without complications. Formation of one minor tension blister; Patient and surgeon were highly satisfied as regards application, wound closure performance, healing status and wearing comfort. Day of Surgery Accident Surgery

5. Leukosan® SkinLink | Bridging the gaps in wound closure Melanoma Excision Day of Surgery Day 9, post Surgery Patient Sex:female Wound Type of Wound:Surgical incision, upper arm Length of Wound:approximately 4 cm Treatment Hospital:San Gerardo Hospital, Monza, Italy date:31.05.2006 Surgeon/ Doctor:Dr. Confalonieri Type of Treatment:surgical excision (melanoma) Wound closure:SkinLink (4 closures, size small) plus subcutaneous sutures Wound healing SkinLink closures were removed on day 9 post surgery; No post surgical complications. Patient and surgeon were highly satisfied as regards application, wound closure performance and healing. Plastic Surgery Day of Surgery

6. Leukosan® SkinLink | Bridging the gaps in wound closure Mammary Reconstruction Day of Surgery Day 7, post Surgery Patient Sex:female Wound Type of Wound:Surgical incision Length of Wound:approximately 10 cm Treatment Hospital:San Gerardo Hospital, Monza, Italy date:22.05.2006 Surgeon/ Doctor:Dr. Confalonieri Type of Treatment:mammary reconstruction Wound closure:SkinLink (3 closures, size large) plus subcutaneous sutures Wound healing SkinLink closures were removed on day 7 post surgery; No post surgical complications. Patient and surgeon were highly satisfied as regards application, wound closure performance and healing status. Plastic Surgery Day of Surgery

7. Leukosan® SkinLink | Bridging the gaps in wound closure Inguinal Hernia Day of SurgeryDay 8, post Surgery Paediatric Surgery Patient Age:2 Sex:male Wound Type of Wound:Surgical incisions right and left, above groin crease Length of Wound:2 and 5 cm Depth of Wound:1 and 1.5 cm Treatment Hospital:UMC St Radboud, Nijmegen, NL Date:23.05.2006 Surgeon/ Doctor:Dr. Severijnen Type of Treatment:Inguinal hernia - surgery Wound closure:SkinLink (2 and 4 closures, size small) plus subcutaneous sutures Wound Healing Follow up visit on day 8 post surgery; No post surgical complications. Surgeon satisfied with healing status and cosmesis. Day of Surgery

8. Leukosan® SkinLink | Bridging the gaps in wound closure Shoulder Surgery Day 3, post SurgeryDay 7, post Surgery Orthopaedics Patient Age:40 Sex:female Wound Type of Wound:Surgical incision Length of Wound:approximately 6 cm Depth of wound:1 cm Treatment Hospital:Orthopaedic practice, Hamburg Date:23.06.2006 Surgeon/ Doctor:Dr. Weinhardt Type of Treatment:Surgery, shoulder Wound closure:SkinLink (3 closures, size small) plus subcutaneous sutures Wound Healing Follow up visits on day 3 and 7 post surgery; No post surgical complications. Surgeon and patient highly satisfied with wound closure performance, healing status, wearing comfort and cosmesis. Day of Surgery

9. Leukosan® SkinLink | Bridging the gaps in wound closure Foot Surgery Day 5, post Surgery Patient Age:69 Sex:female Wound Type of wound:surgical incision Length of Wound:approximately 6 cm Depth of Wound:1 cm Treatment Hospital:Orthopaedic practice, Hamburg Date:02.06.2006 Surgeon/ Doctor:Dr. Weinhardt Type of Treatment:Surgery, foot Wound closure:SkinLink (3 closures, size small) plus subcutaneous sutures Wound Healing Follow up visits on day 3 and 5 post surgery; Change of one closure due to excessive bleeding; No post surgical complications. Surgeon and patient satisfied with wound closure performance, healing status and wearing comfort. Day 3, post Surgery Orthopaedics