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prevents pulmonary thrombosis prevents Is EGCG active on thrombin (Th) ? without changing coagulation parameters (proTh and Th-time) without changing.

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Presentation on theme: "prevents pulmonary thrombosis prevents Is EGCG active on thrombin (Th) ? without changing coagulation parameters (proTh and Th-time) without changing."— Presentation transcript:

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2 prevents pulmonary thrombosis prevents Is EGCG active on thrombin (Th) ? without changing coagulation parameters (proTh and Th-time) without changing coagulation parameters (proTh and Th-time) inhibitsplateletaggregationinhibitsplateletaggregation Kang et al., Throm.Res. 96, 229-237, 1999 2.2 mM ( thrombin > fibrinogen > fibrin > clot ) Garbisa 2001

3 LE Th cath.G MMP-2 uPA (Jankun 97) Differential enzyme inhibition by EGCG EGCG useful in clinical application (inflammation), preserving cathepsin G- or uPA-mediated reactions (Kang 99) Is EGCG directly active on thrombin (Th) ? MMP-12 (Demeule 00) ? other serine-proteinases metallo-proteinases other serine-proteinases metallo-proteinases (Sartor L., Pezzato E., Garbisa S., submitted to J.Leuk.Biol. 2001) Garbisa 2001


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