Presentation on theme: "Optoelectronics & Microsystems Lab"— Presentation transcript:
1 Optoelectronics & Microsystems Lab Politecnico di Milano, Dip. Elettronica e Informazione, Milano, Italy
2 STAFF COVA, S. Full Professor GHIONI, M. Full Professor ZAPPA, F. Associate ProfessorGIUDICE, A. Post-Doc Research AssociateRECH, I. Post-Doc Research AssociateLABANCA, I. Research AssociateGALLIVANONI, A. Research AssociateTISA, S. Ph.D. StudentRESTELLI, A. Ph.D. StudentTOSI, A. Ph.D. StudentGULINATTI, A. Ph.D. Student
3 Core Know-How Microelectronic Detectors and Circuits Measurement Techniques and Instrumentationfor detecting and measuring optical signalswith ultra-high sensitivityand picosecond resolution
4 Recent AchievementUltrasensitive CE-Microchip apparatus for DNA fragment separation collaboration with M. Chiari, CNR Inst. of Chemistry and Molecular Recognition, MilanoReference:I. Rech, A. Restelli, S. Cova, M. Ghioni, M. Chiari, ad M. Cretich,“Microelectronic Photosensors for Genetic Diagnostic Microsystems”Journal of Sensors and Actuators – B , in press 2004
6 Detection limit (@ S/N=3) : 1pM CE Separation in glass microchiprun buffer: TAPS-TRIS 100mM pH 8.5.Sample : 23 mer oligonucleotide labelled with CY 5Detection limit S/N=3) : 1pMcorresponds to < 30 molecules in the injection volume of 50pL
7 Looking inside the apparatus... Compact & low-cost set-up with:Fully automated operationLaser diode excitation of fluorescenceControlled chip temperatureDual wavelength detectionDual HV power supply (0-5kV)Confocal optical schemeRemote controlProblem debug via internet
9 Recent AchievementMicroelectronic Single-Photon Detector for studies on Single-Molecule Dynamicscollaboration with X. Sunney Xie, Harvard University, Dept. of Chemistry and Chemical BiologyReference:H. Yang, G. Luo, P. Karnchanaphanurach, T.M. Louie, I. Rech, S.Cova, L. Xun, and X. Sunney Xie,“Single-Molecule Protein Dynamics on Multiple Time Scales Probed by Electron Transfer”, SCIENCE, Oct.10, 2003, Vol.302,
10 even the best commercially available Photon Counting Modules Xie’s idea: Measuring the delay of the fluorescence photon with respect to the laser excitation with picosecond-resolution, good efficiency and low-noise makes possible to probe the Single-Molecule Protein Dynamics by means of a correlation analysis of the delay fluctuations in real timeHowever:even the best commercially available Photon Counting ModulesDO NOT provide adequate performance!
11 SPTM Single Photon Timing Module for Single-Molecule Experiments FWHM=60psHigh Time-resolution: 60psLow Dark Counts: down to 5 c/sQuantum Detection Efficiency: 500nmSingle power supply +15VControlled Temperature (Peltier cell)Software controlled settingsRS-232 data transmission
12 Recent AchievementNon-invasive testing of ULSI Circuits by Ultrasensitive Picosecond Time-Resolved Luminescence Measurements collaboration with IBM T.J. Watson Research Center, Yorktown Heights, NYReference:Stellari F., Zappa F., Cova S., Porta C., Tsang J.C.,"High-Speed CMOS Circuit Testing by 50ps Time-Resolved Luminescence Measurements"IEEE Trans. Electron Devices, 48, (2001)
13 Recent AchievementPhoton-Counting Quadrant Detectors and Electronics for Adaptive Optics Systems of Advanced Telescopes collaboration with D.Bonaccini, ESO European Southern Observatory, Garching, D and R. Biasi, Microgate, Bolzano, IReference:development of the STRAP (System for Tip-tilt Removal with Avalanche Photodiodes) for the VLT Observatory, Cerro Paranal, Chile
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