Urea is nitrogen compound, formed almost solely in the liver From the catabolism of amino acids and is the main excretion product of protein metabolism
Introducton The concentration of urea in the blood serum represent mainly a balance between urea formation from protein catabolism and urea excretion by kidney.
Introducton If kidney fail, blood urea Conc. Increase to high level and toxic condition known as (Uremia ) will result. In uremia, urea must be removed from the blood by clinical procedure called “Blood Dialysis “
Azotemia :- Is a term used for a high blood serum urea concentration Uraemia :- ( as opposed to Azotemia) Is the name given to the clinical syndrom that develops when there is nitrogen retention due to renal failure
Low Serum urea 1.Late pregnancy Due to : glomerluar filtration rate (GFR) Use of N by fetus Water retention 2. Liver disease 3.long term of protein malnutrition Increase rate of protein anabolism Long term replacement of blood loss with intravenous dextran or glucose or saline (Dilution )