AF Survey Final Report AUGUST 2014 Prepared by:. www. russellresearch.com 1 Study Overview The purpose of this study was to evaluate the impact of Atrial.

AF Survey Final Report AUGUST 2014 Prepared by:

www. russellresearch.com 1 Study Overview The purpose of this study was to evaluate the impact of Atrial Fibrillation (AFib)-related stroke on patients and caregivers, and to evaluate physician perceptions toward treatment and patient understanding of issues surrounding the condition. Specific research objectives were to:  Understand the impact of AFib-related stroke on patients and caregivers  Measure awareness of facts surrounding AFib and stroke  Uncover the barriers to communication between patients/caregivers and providers related specifically to AFib and stroke  Identify barriers in understanding risk factors  Determine steps taken to learn more about AFib  Evaluate experiences living with AFib and experiencing stroke To meet those objectives, Russell Research, an independent survey research firm, conducted a telephone and online study among the following populations: 507 Physicians  202 Cardiologists (sample error of +/- 6.9 percent)  101 Electrophysiologists (sample error of +/- 9.8 percent)  53 Neurologists (sample error of +/- 13.5 percent)  151 Primary Care Physicians/Internal Medicine/Family Medicine (referred to as “General Practitioners” in the report) (sample error of +/- 8.0 percent)  At a 95 percent confidence level, a margin of sample error of +/- 4.4 percent applies to the total physician sample. 499 Atrial Fibrillation patients  248 Atrial Fibrillation-only (sample error of +/- 6.2 percent)  251 Stroke Survivors (sample error of +/- 6.2 percent)  At a 95 percent confidence level, a margin of sample error of +/- 4.4 percent applies to the total patient sample. 203 Caregivers of Stroke Survivors with Atrial Fibrillation At a 95 percent confidence level, a margin of sample error of +/- 6.9 percent applies to the total caregiver sample. Interviewing for the study was conducted from May 27 – July 3, 2014. Introduction and Methodology

www. russellresearch.com 2 Sample Criteria In order to qualify for study inclusion, respondents were screened to meet the following criteria: Physicians  Ages 25 or older  Have treated 10 or more AFib-related stroke patients in the past year (25 or more for Neurologists)  Spend 70% or more of their time in clinical practice or direct patient care  Board certified or board-eligible  No pharmaceutical manufacturer employees in household  Regularly see Atrial Fibrillation patients (Stroke patients for Neurologists)  Average patient age is 18 or older Atrial Fibrillation Patients  Have been diagnosed with Atrial Fibrillation  Stroke Survivors have experienced a stroke in the past Caregivers  Currently a caregiver for someone who has been diagnosed with Atrial Fibrillation and has experienced a stroke in the past Introduction and Methodology

www. russellresearch.com 3 Sample Source & Methodology Respondents for the study were sourced and interviewed as follows: Physicians: Online Methodology  Cardiologists: M3 Medical Market Research  Electrophysiologists: M3 Medical Market Research & Heart Rhythm Society  53 Neurologists: M3 Medical Market Research & National Stroke Association  151 General Practitioners: M3 Medical Market Research Atrial Fibrillation Patients  Atrial Fibrillation Patients: Conducted online, sample provided by Survey Sampling International & Research Now  Stroke Survivors: Conducted online and via telephone, sample provided by National Stroke Association, Survey Sampling International & Research Now Caregivers  Conducted online and via telephone, sample provided by National Stroke Association, Survey Sampling International & Research Now Introduction and Methodology

www. russellresearch.com 4 Statistical Notation The statistical significance of a result in this survey is the probability that the observed relationship (e.g., between variables) or a difference (e.g., between means) in a sample occurred by pure chance, and that in the population from which the sample was drawn, no such relationship or differences exist. Using less technical terms, one could say that the statistical significance of a result tells us something about the degree to which the result is "true". More technically, the value of the p-value represents a decreasing index of the reliability of a result. The higher the p-value, the less we can believe that the observed relation between variables in the sample is a reliable indicator of the relation between the respective variables in the population. Specifically, the p-value represents the probability of error that is involved in accepting our observed result as valid, that is, as "representative of the population." For example, a p-value of.05 (i.e.,1/20) indicates that there is a 5% probability that the relation between the variables found in our sample is a "fluke." The following statistical notations are used throughout the report: =Indicates figure is significantly higher than other sub-group at a 95% confidence level (i.e. p-value of.05 or less). C = Cardiologists E = Electrophysiologists N = Neurologists P = General Practitioner (PCP/IM/FM) Statistical Notation

www. russellresearch.com 5 Detailed Findings Executive Summary

www. russellresearch.com 6 Physicians A majority of physicians believe most Atrial Fibrillation patients don’t usually understand their increased risk of stroke and feel most patients underestimate the impact ischemic stroke can have on their lives.  Virtually all physicians (97%) agree that AFib-related ischemic stroke can have devastating outcomes.  More than one-half of physicians (55%) indicate their typical Atrial Fibrillation patient does not usually understand their risk of ischemic stroke due to Atrial Fibrillation.  Nine in ten physicians (90%) believe that many Atrial Fibrillation patients underestimate the impact an AFib-related stroke could have on their everyday lives.  Four in five physicians (79%) believe many AFib patients are in denial about their risk of experiencing an ischemic stroke. Reducing the risk of Atrial Fibrillation-related ischemic stroke is almost always the primary objective when prescribing anticoagulation therapy. A variety of compliance barriers exist, and typically vary by specialty.  More than four in five physicians (85%) indicate their primary objective when prescribing anticoagulation therapy to patients with Atrial Fibrillation is to reduce the risk of AFib-related ischemic strokes.  However, bleeding (65%) and the overall safety profile of medication (62%) are leading concerns when prescribing anticoagulation therapy. Additionally, three in five Neurologists (62%) identify minimizing the risk of hemorrhagic stroke as a primary concern.  Four in five physicians (79%) believe too many patients underestimate the importance of adhering to their prescribed therapy for reducing the risk of AFib-related ischemic stroke.  Risk of bleeding is the largest compliance barrier for Electrophysiologists (35%) and Cardiologists (31%), while monitoring anti-coagulation effect is the most common barrier for Neurologists (53%) and General Practitioners (36%). Executive Summary

www. russellresearch.com 7 Physicians (Cont’d.) Physicians typically initiate conversations about the increased risk of AFib-related stroke and treatment. They see a variety of barriers to educating patients about their condition and seek support as they try to provide counsel.  Nine in every ten conversations (90%) between physicians and patients about increased risk of AFib-related stroke and available treatments are initiated by physicians.  Other than personally discussing their situation with patients (87% discuss condition, 82% to discuss treatment), there are no other widely used methods of patient education. Written materials are used by one-half of physicians (52%) for information on the condition, and less than one-half use them to educate about treatment options (45%).  In these discussions, the two most widely perceived barriers to educating Atrial Fibrillation patients is that they believe once their symptoms are being treated, the risk of AFib-related stroke goes away (43%) and patients feeling that the risks outweigh the benefits for medications reducing the risk of AFib-related stroke (41%).  More than four in five physicians (83%) wish they had more information/educational materials to share with their Atrial Fibrillation patients that discuss stroke risk associated with Atrial Fibrillation.  In terms of specific materials, three in four physicians (76%) would like to have educational brochures, pamphlets, or posters as resources to discuss stroke risk and treatment options with their Atrial Fibrillation patients and caregivers, and more than two in five (44%) would like web-based illustrations/animation. Further, many physicians believe their colleagues are not doing enough to educate patients about the risk of ischemic stroke in Atrial Fibrillation patients and urge their peers to be mindful of the risk.  Three in four physicians (76%) regularly advise or remind their colleagues of the increased risk for ischemic stroke among Atrial Fibrillation patients.  Two in three physicians (67%) feel many of their colleagues don't do enough to educate Atrial Fibrillation patients about the risks of AFib-related ischemic strokes. Executive Summary

www. russellresearch.com 8 Atrial Fibrillation Patients The impact of Atrial Fibrillation and related stroke can be devastating, with a majority of survivors not even diagnosed prior to experiencing a stroke. Survivors wish they had known more about stroke, as there is a widely held belief that experiencing a stroke was worse than they could have imagined.  Three in five survivors (61%) did not know they suffered from Atrial Fibrillation prior to experiencing a stroke.  Only one-third of stroke survivors who spoke with their physician about Atrial Fibrillation (35%) discussed the impact of AFib-related stroke on everyday life.  Five in six stroke survivors (83%) wish they had known more about reducing the risk of an AFib-related stroke prior to experiencing a stroke.  More than three in four stroke survivors (77%) indicate their life has not been the same since experiencing an AFib-related stroke, and nearly three in four (73%) agree that experiencing a stroke was worse than they had imagined.  Although two-fifths of survivors don’t go out as much since having a stroke (40%) and have experienced depression (39%), three in five (60%) have attempted to live healthier lives. Meanwhile, an alarming percentage of Atrial Fibrillation-only patients are not aware of nor understand the differences between different types of stroke, and couldn’t recognize the symptoms if one were to occur.  Less than one-half of Atrial Fibrillation-only patients (45%) are aware there are different stroke types, and less than two-fifths (38%) are familiar with ischemic stroke. When provided with a description, less then three in ten (28%) identified an obstruction within a blood vessel supplying blood to the brain as ischemic stroke.  One-third of Atrial Fibrillation-only patients (32%) don’t believe they would be able to describe the most common symptoms of stroke. Most patients will eventually have a discussion with their physician about the increased risk of ischemic stroke, however many important issues are left out of conversation.  More than four in five Atrial Fibrillation patients (85%) have had a discussion with their physician about the increased risk of stroke due to Atrial Fibrillation.  However, more than one-third of patients (36%) were not initially informed by their physician that they may be at an increased risk of stroke.  Additionally, only two-thirds of AFib-only patients (65%) and less than one-half of survivors (48%) have discussed the risk of AFib-related stroke with and without medication.  On average, patients who have discussed the issue with their patients indicate they initiate the conversation 47% of the time – far different than reported by physicians (10%). Executive Summary

www. russellresearch.com 9 Atrial Fibrillation Patients (Cont’d.) Atrial Fibrillation patients are eager for information about how to reduce their personal risk of ischemic stroke. Despite this eagerness, many are not receiving materials that could provide further education.  Five in six AFib-only patients (87%) will seek to find out everything they can about Atrial Fibrillation and reducing their risk of AFib-related stroke.  More than four in five of all Atrial Fibrillation patients (82%) would be interested in learning more about how to reduce their risk of AFib-related ischemic stroke.  Less than one-half of patients (48%) indicate their physician gave them written materials to read regarding Atrial Fibrillation and the increased risk of AFib-related stroke.  Four in five AFib-only patients (80%) would like to have more information to take charge of their Atrial Fibrillation and learn about reducing the risk of AFib-related stroke. There are a wide range of important facts about Atrial Fibrillation-related stroke that are unknown to a relatively high percentage of patients.  More than two in three Atrial Fibrillation patients (68%) were not previously aware that AFib- related strokes are nearly twice as likely to be fatal or disabling as non-AFib-related strokes.  More than one-third of Atrial Fibrillation patients (36%) were not previously aware that you can have 5 times greater risk for stroke if you are living with untreated Atrial Fibrillation.  Less than three in ten Atrial Fibrillation patients (27%) believed women had a higher risk of Atrial Fibrillation-related stroke than men. Despite a lack of information, a high percentage of patients have taken medication and are compliant.  Six in seven patients who have discussed Atrial Fibrillation-related stroke with their physician (87%) have taken medication to reduce their risk of stroke. Oral anticoagulants (72%) are most commonly prescribed.  More than nine in ten patients who have taken medication (92%) regularly take their prescribed treatment to reduce their risk of AFib-related stroke.  Two in five patients who discussed an increased stroke risk with physicians (39%) named using a treatment that reduces the risk of a stroke caused by a blood clot in the brain to be the most important quality, and three in five (59%) named it as one of their two most important qualities.  Motor limitations are of primary concern in experiencing a stroke – one-third of patients (32%), including two-fifths of AFib-only patients (40%), indicated losing the ability to move, talk, or some other physical function concerns them most about having a stroke. Executive Summary

www. russellresearch.com 10 Caregivers Caregivers tend to provide assistance and care for stroke survivors who are in “worse shape” than the average survivor.  On average, caregivers are providing assistance to survivors during 47% of their everyday activities. Survivors that were interviewed had indicated they required assistance 12% of the time, with three-fifths (61%) not requiring any assistance at all.  One in seven caregivers (14%) provide assistance 100% of the time survivors are doing everyday activities, and one in two (50%) provide assistance at least half of the time survivors are doing everyday activities.  The survivors in their care are more likely to have experienced a range of limitations:  92% experienced motor limitations within their first 6 months, compared to 81% of the overall survivor population  94% of these survivors still experience motor limitations, compared to 80% of the overall population  81% experienced cognitive limitations within their first 6 months, compared to 52% of the overall survivor population  69% experienced sensory limitations within their first 6 months, compared to 54% of the overall survivor population  43% experienced vision limitations within their first 6 months, compared to 31% of the overall survivor population This situation places a crushing burden on caregivers which impacts personal time, relationships and emotions.  More than nine in ten caregivers (92%) feel they have a lot more responsibilities since becoming a caregiver.  Nine in ten caregivers (91%) agree that their lives have not been the same since the person in their care experienced an AFib-related stroke.  Six in seven caregivers (86%) couldn’t have imagined the amount of work it takes to care for a stroke survivor.  Two in three caregivers (66%) don’t have as much time to do activities or hobbies that bring them joy.  Three in five caregivers (60%) feel like they have more to do than they can handle.  More than two in three caregivers (68%) feel their relationship is different with their patient since they suffered a stroke.  Nearly three in five caregivers (56%) feel more socially isolated. Executive Summary

www. russellresearch.com 11 Caregivers (Cont’d.) Despite this burden, caregivers are dedicated to assisting the survivor in their care and stay informed about Atrial Fibrillation and associated stroke risks, including being an active participant in the survivor’s medical care. Most of these caregivers are knowledgeable about ischemic stroke.  Nearly nine in ten caregivers (86%) indicated they were aware there were different types of strokes.  Three in four caregivers (76%) are familiar with ischemic stroke, and two-fifths are very familiar. Additionally, more than two in three caregivers (68%) were able to correctly identify an ischemic stroke as being caused by an obstruction within a blood vessel supplying blood to the brain.  Four in five caregivers (82%) accompany the survivor in their care to doctor’s appointments always or most of the time.  More than three in four caregivers who attend doctor visits (78%) indicate the survivor’s physician has directly discussed Atrial Fibrillation and the increased risk of stroke, and more than three-fifths of caregivers (62%) have themselves discussed the increased risk of stroke due to Atrial Fibrillation with the physician.  On average, caregivers indicated more than three in four (78%) conversations about treatments to reduce the risk of Atrial Fibrillation related stroke are initiated by the physician. This is more in line with what physicians have reported (90% of conversations) compared to Atrial Fibrillation patients (53%). A majority of caregivers have not received written information from physicians and have been forced to search for it on their own. This has led to most caregivers reporting that they would have liked to had more information.  After the survivor in their care was diagnosed with Atrial Fibrillation, four in five caregivers (81%) tried to find out everything they could about it and reducing AFib-related stroke risk.  Less than two in five caregivers who attend doctor visits (38%) indicate physicians have given written materials to read regarding Atrial Fibrillation or the increased risk of AFib-related stroke.  Seven in ten caregivers (69%) have personally sought out information related to Atrial Fibrillation or AFib-related strokes.  Of caregivers who have researched Atrial Fibrillation, more than three-quarters (77%) obtained information from an association or website related specifically to heart conditions or AFib-related stroke and a slight majority (54%) looked at written materials.  Nine in ten caregivers (89%) would have liked to have had more information about Atrial Fibrillation and learned more about AFib-related stroke. Executive Summary

www. russellresearch.com 12 Caregivers (Cont’d.) Beyond information, many caregivers indicate they could benefit from various types of other assistance.  Five in six caregivers (83%) wish they had more support and information to take care of the survivor in their care.  Seven out of ten caregivers (70%) would find physical help useful in helping provide care.  More than three in five caregivers would find home modifications (63%), financial assistance (63%) and respite care (62%) useful in helping provide care. Executive Summary

www. russellresearch.com 13 Detailed Findings: Physicians

www. russellresearch.com 14 Number of Atrial Fibrillation Patients See Per Year Detailed Findings: Physicians Base: Total Respondents (n=507) 1a. In an average 12 month time period, how many patients with Atrial Fibrillation (AFib) do you see? Electrophysiologists and Cardiologists see far more AFib patients than Neurologists and General Practitioners.  On average, physicians see a total of 160 Atrial Fibrillation patients each year. This ranges from 98 patients per year among Neurologists to 215 patients seen by the average Electrophysiologist.  More than two-fifths of physicians (42%) see 200 or more Atrial Fibrillation patients each year.  Seven in ten Electrophysiologists (73%) see 200 or more Atrial Fibrillation patients each year.  More than nine in ten Neurologists (92%) see less than 200 Atrial Fibrillation patients each year. Specialty Cardio- logist Electro- physiologist Neuro- logist PCP/ Internal/ Family Total Respondents (202)(101)(53)(151) %% CENP Under 100 1896057 100 to 199 29183226 200 or more 5373817 Mean 18721598108 EENPCNPCEE Mean: 160 CNPNP

www. russellresearch.com 15 Percentage of Atrial Fibrillation Patients With History of Stroke Detailed Findings: Physicians Base: Total Respondents (n=507) 1b. And what percentage of your AFib patients have had a history of stroke? The majority of AFib patients seen by Neurologists have a history of stroke.  On average, one-fifth of Atrial Fibrillation patients seen by physicians (20%) have a history of stroke.  More than one-half of patients seen by Neurologists (53%) have a history of stroke.  One-fifths of patients seen by General Practitioners (21%) have a history of stroke.  One in seven patients seen by Cardiologists (15%) have a history of stroke.  One in ten patients seen by Electrophysiologists (10%) have a history of stroke, and one-half of EPs (51%) indicate less than 10% of their Atrial Fibrillation patients have a history of stroke. Specialty Cardio- logist Electro- physiologist Neuro- logist PCP/ Internal/ Family Total Respondents (202)(101)(53)(151) %% CENP 1% to 9%3351-17 10% to 24%50432144 25% to 100%1867939 Mean15105321 NENPCEPCE N CNPN Mean: 20%

www. russellresearch.com 16 Types of Oral Treatments Prescribe To Atrial Fibrillation Patients to Reduce Risk of Stroke Detailed Findings: Physicians Base: Total Respondents (n=507) 2. In terms of reducing the risk of stroke in Atrial Fibrillation, what types of oral treatment options do you currently prescribe to your at-risk patients? Oral anticoagulants are universally prescribed to reduce the risk of stroke in Atrial Fibrillation patients.  Physicians universally prescribe oral anticoagulants to Atrial Fibrillation patients to reduce the risk of stroke (100%).  Four-fifths of physicians (79%) prescribe antiplatelets to Atrial Fibrillation patients to reduce the risk of stroke.

www. russellresearch.com 17 Oral Treatment Share of Prescription Detailed Findings: Physicians Base: Total Respondents (n=507) 3. What percentage of the time do you prescribe each of the following oral treatment options to your at-risk patients with Atrial Fibrillation to reduce their risk of stroke? Oral anticoagulants are prescribed in the vast majority of cases when treating at-risk patients with Atrial Fibrillation.  Four-fifths of oral treatment prescriptions (80%) made by physicians to at- risk patients with Atrial Fibrillation are oral anticoagulants.  Nearly nine in ten oral treatment prescriptions (88%) made by Electrophysiologists to at-risk patients with Atrial Fibrillation are oral anticoagulants.  More than one-quarter of oral treatment prescriptions (27%) made by General Practitioners to at-risk patients with Atrial Fibrillation are antiplatelets. Specialty Cardio- logist Electro- physiologist Neuro- logist PCP/ Internal/ Family Total Respondents (202)(101)(53)(151) %% CENP Oral anticoagulant 82887873 Antiplatelet17122227 PPCE

www. russellresearch.com 18 Primary Objective When Prescribing Anticoagulation Therapy Detailed Findings: Physicians Base: Total Respondents (n=507) 4. Of the following options, which best describes your primary objective when prescribing anticoagulation therapy for patients with Atrial Fibrillation? Reducing the risk of AFib-related ischemic stroke is almost always the primary objective when physicians prescribe anticoagulation therapy.  More than four in five physicians (85%) indicate their primary objective when prescribing anticoagulation therapy to patients with Atrial Fibrillation is to reduce the risk of AFib-related ischemic strokes.  Seven percent of physicians indicate their primary objective when prescribing anticoagulation therapy to patients with Atrial Fibrillation is the overall safety profile of the medication.  Three percent of physicians indicate their primary objective when prescribing anticoagulation therapy to patients with Atrial Fibrillation is to minimize potential adverse effects.  Three percent of physicians indicate their primary objective when prescribing anticoagulation therapy to patients with Atrial Fibrillation is to minimize the risk of hemorrhagic strokes.

www. russellresearch.com 19 Bleeding and the overall safety profile are leading concerns when prescribing anticoagulation therapy.  A patient’s bleeding risk is of primary concern to two in three physicians when prescribing anticoagulation therapy (65%) and it is the greatest concern to one in four physicians (25%).  The overall safety profile of the medication is of primary concern to more than three in five of physicians when prescribing anticoagulation therapy (62%) and it is the greatest concern to more than one in four physicians (27%).  Minimizing the risk of hemorrhagic strokes is of primary concern to one in two physicians when prescribing anticoagulation therapy (50%) and it is the greatest concern to one in seven physicians (14%).  Compliance is of primary concern to one in two physicians when prescribing anticoagulation therapy (49%) and it is the greatest concern to eight percent of physicians. Concerns When Prescribing Anticoagulation Therapy Detailed Findings: Physicians Base: Total Respondents (n=507) 5a.When using anticoagulants to reduce the risk of stroke resultant from atrial fibrillation, what are your primary concerns? 5b.When using anticoagulants to reduce the risk of stroke resultant from atrial fibrillation, what do you see as the greatest concern?

www. russellresearch.com 20 Neurologists tend to have a broader range of concerns than other physicians when prescribing anticoagulation therapy.  Three in five Neurologists (62%) indicate minimizing the risk of hemorrhagic strokes is of primary concern when prescribing anticoagulation therapy. This is a significantly higher percentage when compared to Electrophysiologists (45%) and General Practitioners (46%), and was also higher when compared to Cardiologists (52%).  One in two Neurologists (49%) indicate reversibility of the anticoagulant effect is of primary concern when prescribing anticoagulation therapy. This is a significantly higher percentage when compared to Electrophysiologists (28%) and Cardiologists (34%), and was also higher when compared to General Practitioners (35%). Primary Concerns When Prescribing Anticoagulation Therapy Detailed Findings: Physicians Base: Total Respondents (n=507) 5a.When using anticoagulants to reduce the risk of stroke resultant from atrial fibrillation, what are your primary concerns? Total ConcernsSpecialty Total Cardio- logist Electro- physiologist Neuro- logist PCP/ Internal/ Family Total Respondents (507)(202)(101)(53)(151) %%% CENP Patient's bleeding risk65 5968 Overall safety profile of the medication6263626461 Minimizing the risk of hemorrhagic strokes 5052456246 Compliance4948415356 Potential Adverse Events4543355552 Cost4339484047 Reversibility of the anticoagulant effect 3534284935 Food and drug interactions29 263428 Dosing schedule for the patient2728242330 Patient preference20 161523 Need for dual anti-platelet therapy1923241113 PPCEE E EP

www. russellresearch.com 21 Case Study Treatment Recommendation Detailed Findings: Physicians Base: Total Respondents (n=507) 6. Based on your experience, which of the following would you recommend for reducing this patient’s risk of stroke in atrial fibrillation? When presented with a case study for reducing the risk of stroke in Atrial Fibrillation, an oral anticoagulant is selected for treatment by a majority of physicians.  Based on the case study, nearly two in three physicians (64%) would recommend an oral anticoagulant for reducing the patient’s risk of stroke in Atrial Fibrillation.  Based on the case study, nearly one in seven physicians (13%) would recommend a high-dose aspirin for reducing the patient’s risk of stroke in Atrial Fibrillation.  Based on the case study, nearly one in seven physicians (13%) would recommend a low-dose aspirin for reducing the patient’s risk of stroke in Atrial Fibrillation.  Based on the case study, seven percent of physicians would recommend a dual antiplatelet for reducing the patient’s risk of stroke in Atrial Fibrillation. A 67 year old woman with hypertension presents with recurrent episodes of paroxysmal atrial fibrillation. She has no other past medical history. This patient has a CHADS2 score of 1 (hypertension) and CHA2DS2VASc score of 3 (hypertension, woman, age >65)

www. russellresearch.com 22 Treatment Conversation Initiation Percentage Share Detailed Findings: Physicians Base: Total Respondents (n=507) 7. Thinking about conversations you have had with your patients with Atrial Fibrillation about their increased risk of AFib-related stroke and available treatments, what percentage of the time would you say conversations are initiated by you versus those initiated by patients? Physicians almost always initiate discussions about the increased risk of AFib-related stroke and available treatments.  Nine in every ten conversations (90%) between physicians and patients about increased risk of AFib-related stroke and available treatments are initiated by physicians.  One in every ten conversations (10%) between physicians and patients about increased risk of AFib-related stroke and available treatments are initiated by patients.

www. russellresearch.com 23 Risk of bleeding and other adverse events are often viewed as the leading barrier to initiating therapy.  A patient’s bleeding risk is the greatest barrier to three in ten physicians (31%) when initiating therapy to reduce the risk of stroke in patients with Atrial Fibrillation, and is within the three greatest concerns to more than one in two physicians (56%).  The risk of adverse events is the greatest barrier to nearly one in seven physicians (13%) when initiating therapy to reduce the risk of stroke in patients with Atrial Fibrillation, and is within the three greatest concerns to more than one in three physicians (35%).  Patient resistance is the greatest barrier to one in seven physicians (14%) when initiating therapy to reduce the risk of stroke in patients with Atrial Fibrillation, and is within the three greatest concerns to three in ten physicians (30%).  Affordability is the greatest barrier to one in ten physicians (10%) when initiating therapy to reduce the risk of stroke in patients with Atrial Fibrillation, and is within the three greatest concerns to one in three physicians (33%). Three Greatest Barriers When Initiating Therapy To Reduce Risk Of Stroke Detailed Findings: Physicians Base: Total Respondents (n=507) 8. From your experience, which of the following do you view as the greatest, second greatest and third greatest barriers when initiating therapy to reduce the risk of stroke in patients with atrial fibrillation?

www. russellresearch.com 24 The greatest barrier to initiating therapy often differs by physician specialty.  Patient resistance is the greatest barrier to nearly three in ten Electrophysiologists (28%), a significantly higher percentage when compared to all other physician segments.  Patient risk of bleeding is the greatest barrier to more than two in five Neurologists (43%), a significantly higher percentage when compared to General Practitioners (26%) and Electrophysiologists (23%).  Routine lab work required for monitoring is the greatest barrier to one in nine General Practitioners (11%), a significantly higher percentage when compared to Cardiologists (5%) and Electrophysiologists (1%). Greatest Barrier When Initiating Therapy To Reduce Risk Of Stroke Detailed Findings: Physicians Base: Total Respondents (n=507) 8. From your experience, which of the following do you view as the greatest, second greatest and third greatest barriers when initiating therapy to reduce the risk of stroke in patients with atrial fibrillation? Greatest BarrierSpecialty Total Cardio- logist Electro- physiologist Neuro- logist PCP/ Internal/ Family Total Respondents (507)(202)(101)(53)(151) %%% CENP Patient risk of bleeding 3135234326 Patient resistance 14152828 Risk of adverse events 1310112115 Affordability 10111747 Routine lab work required for monitoring 651611 Prior authorizations or managing insurance coverage 67825 Patient risk of falling 54385 Patient tolerability 32125 Time to counsel patients on medication risks and benefits 31424 Drug-drug interactions 22--5 Unsure of patient's stroke risk 21163 Unsure of patient's bleed risk 22142 Lack of patient education resources 21221 Dietary restrictions 11--1 Lack of samples 11--1 Time to counsel patients on dietary restrictions 101-1 NPECNPCEPCCEENP

www. russellresearch.com 25 Electrophysiologists particularly see different barriers to therapy initiation.  Patient resistance is one of the three greatest barriers to nearly one in two Electrophysiologists (48%), a significantly higher percentage when compared to all other physician segments.  Affordability is one of the three greatest barriers to nearly one in two Electrophysiologists (47%), a significantly higher percentage when compared to all other physician segments.  Separately, patient risk of falling is one of the three greatest barriers to more than one in two Neurologists (53%), a significantly higher percentage when compared to all other physician segments. Detailed Findings: Physicians Base: Total Respondents (n=507) 8. From your experience, which of the following do you view as the greatest, second greatest and third greatest barriers when initiating therapy to reduce the risk of stroke in patients with atrial fibrillation? Top Three Greatest BarriersSpecialty Total Cardio- logist Electro- physiologist Neuro- logist PCP/ Internal/ Family Total Respondents (507)(202)(101)(53)(151) %%% CENP Patient risk of bleeding 5654 6056 Risk of adverse events 3532334238 Affordability 3335471330 Patient risk of falling 3135225326 Patient resistance 3033481720 Routine lab work required for monitoring 2519152640 Prior authorizations or managing insurance coverage 2022 1121 Drug-drug interactions 131271716 Time to counsel patients on medication risks and benefits 11818811 Unsure of patient's bleed risk 10 8198 Patient tolerability 10134119 Dietary restrictions 67448 Unsure of patient's stroke risk 645137 Lack of patient education resources 67825 Time to counsel patients on dietary restrictions 44225 Lack of samples 34223 Other 113-- NENPECNP CPCEPEPCNCEE Three Greatest Barriers When Initiating Therapy To Reduce Risk Of Stroke

www. russellresearch.com 26 Greatest Barrier to Patient Compliance Detailed Findings: Physicians Base: Total Respondents (n=507) 9. From your experience, what do you see as the greatest barrier to patient compliance in treatment therapy to reduce the risk of ischemic stroke due to AFib? Monitoring anticoagulation effect and risk of bleeding are the largest compliance barriers, though it varies by physician specialty.  Monitoring anticoagulation effect is the greatest barrier to patient compliance for nearly three in ten physicians (28%), including more than one in two Neurologists (53%) and more than one in three General Practitioners (36%).  Patient concern about the risk of bleeding is the greatest barrier to patient compliance for one in four physicians (26%), including more than one in three Electrophysiologists (35%) and three in ten Cardiologists (31%).  Patient concern about cost is the greatest barrier to patient compliance for one in six physicians (17%), including one in five Electrophysiologists (21%) and Cardiologists (20%), and one in six General Practitioners (16%). However, it is the greatest barrier to only two percent of Neurologists. Specialty Cardio- logist Electro- physiologist Neuro- logist PCP/ Internal Family Total Respondents(202)(101)(53)(151) %% CENP Monitoring anticoagulation effect 22145336 Patients are concerned about the risk of bleeding 31352314 Patients are concerned about cost 2021216 Patient belief that they are at low-risk for stroke due to atrial fibrillation 10181312 Patients experiencing side effects due to the medication 86811 Dietary restrictions43-5 Patients are more concerned about AFib symptom management 32-5 Number of daily doses12-2 PPNNCEPCEN

www. russellresearch.com 27 Level of Patient Understanding Regarding Increased Risk of Ischemic Stroke Due to Atrial Fibrillation Detailed Findings: Physicians Base: Total Respondents (n=507) 10. Overall, which of the following statements accurately describes your typical patient’s understanding of how Atrial Fibrillation increases their risk of ischemic stroke? A majority of AFib patients don’t usually understand their risk of ischemic stroke.  When asked to best describe the typical patient’s understanding of how Atrial Fibrillation increases their risk of ischemic stroke, more than one in two physicians (55%) indicate their average AFib patient does not usually understand their risk.  One in three physicians (34%) indicate their average AFib patient is actively looking for ways to reduce their risk of ischemic stroke.  One in five physicians (19%) indicate their typical AFib patient is very knowledgeable about their risk of ischemic stroke.  Two in three Electrophysiologists (65%) indicate their average AFib patient does not usually understand their risk of ischemic stroke.  Two in five Neurologists (43%) and General Practitioners (40%) indicate their average AFib patient is actively looking for ways to reduce their risk of ischemic stroke.  One in four Cardiologists (25%) indicate their typical AFib patient is very knowledgeable about their risk of ischemic stroke. Specialty Cardio- logist Electro- physico -logist Neuro- logist PCP/ Internal/ Family Total Respondents (202)(101)(53)(151) %% CENP Average AFib patients do not usually understand their risk of ischemic stroke due to AFib 51654956 Average AFib patients are actively looking for ways to reduce their risk of ischemic stroke due to AFib 32264340 Typical AFib patients are very knowledgeable about their risk of ischemic stroke due to AFib 25131715 CEPEE

www. russellresearch.com 28 Patient Consideration Importance Detailed Findings: Physicians Base: Total Respondents (n=507) 11. How important do you think the following considerations are for your patients with Atrial Fibrillation? Physicians believe a wide range of treatment option considerations are deemed important by Atrial Fibrillation patients.  Virtually all physicians indicate patients find it important to reduce the risk of stroke due to atrial fibrillation (96%).  More than nine in ten physicians indicate patients consider minimizing the risk of hemorrhagic stroke to be important (93%).  More than nine in ten physicians indicate patients consider being able to follow the treatment or dosing regimens to be important (92%).  More than nine in ten physicians indicate patients consider being able to afford their medication to be important (92%).  More than nine in ten physicians indicate patients consider understanding Atrial Fibrillation and the associated risk of stroke to be important (92%).  Nine in ten physicians indicate patients consider reducing the symptoms of Atrial Fibrillation to be important (90%).

www. russellresearch.com 29 Ways Attempt To Educate Patients With AFib About Specifics Of Condition & Increased Risk Of Atrial Fibrillation-Related Stroke Detailed Findings: Physicians Base: Total Respondents (n=507) 12. In which, if any, of the following ways do you try to educate your patients with Atrial Fibrillation about the specifics of their condition and their increased risk of AFib-related stroke? Direct discussion is the most universal method used to educate Atrial Fibrillation patients about increased risk of AFib-related stroke.  Nearly nine in ten physicians (87%) educate AFib patients about their condition by personally discussing the situation with them directly.  One in two physicians (52%) educate AFib patients about their condition by giving them written material to read.  Two in five physicians (40%) educate AFib patients about their condition by having a nurse, educator, or other professional in their office discuss their situation with them.  One in five physicians (21%) educate AFib patients about their condition by directing them to associations or websites related specifically to heart conditions or AFib-related stroke.

www. russellresearch.com 30 The belief that risk goes away, risks of treatment outweigh benefits, and difficulty in understanding the situation are all common barriers to patient education.  More than one in five physicians (22%) believe the primary barrier to educating Atrial Fibrillation patients is the feeling that the risks outweigh the benefits for medications reducing the risk of AFib- related stroke, and two in five (41%) view it as a barrier overall.  One in five physicians (22%) believe the primary barrier to educating Atrial Fibrillation patients is they think that once their symptoms are being treated, the risk of AFib-related stroke goes away, and more than two in five (43%) view it as a barrier overall.  One in six physicians (17%) believe the primary barrier to educating Atrial Fibrillation patients is they have trouble understanding what physicians are trying to explain to them, and two in five (40%) view it as a barrier overall. Barriers To Educating Patients About Condition and Increased Risk for AFib-related stroke Detailed Findings: Physicians Base: Total Respondents (n=507) 13a. What do you see as barriers in terms of trying to educate your patients with Atrial Fibrillation about the specifics of their condition and their increased risk of AFib-related stroke? 13b. And what do you see as the primary barrier in terms of trying to educate your patients with Atrial Fibrillation about the specifics of their condition and their increased risk of AFib-related stroke?

www. russellresearch.com 31 Ways Attempt To Educate Patients With Atrial Fibrillation About Treatment Options Detailed Findings: Physicians Base: Total Respondents (n=507) 14. In which, if any, of the following ways do you try to educate your patients with Atrial Fibrillation about treatment options to reduce the risk of AFib-related stroke? Patient discussion and to a lesser extent, giving written materials, are the most common methods used to educate patients about treatment options.  More than four in five physicians (82%) attempt to educate AFib patients about treatment options by personally discussing the situation with them directly.  More than two in five physicians (45%) attempt to educate AFib patients about treatment options by giving them written material to read.  More than one in three physicians (36%) attempt to educate AFib patients about treatment options by having a nurse, educator, or other professional in their office discussion their situation with them.  One in five physicians (20%) attempt to educate AFib patients about treatment options by directing them to associations or websites related specifically to heart conditions or AFib-related stroke.

www. russellresearch.com 32 Barriers To Educating Patients About Treatment Options Detailed Findings: Physicians Base: Total Respondents (n=507) 15a. What do you see as barriers in terms of trying to educate your patients with Atrial Fibrillation about treatment options to reduce the risk of AFib-related ischemic stroke? 15b. And what do you see as the primary barrier in terms of trying to educate your patients with Atrial Fibrillation about treatments options to reduce the risk of ischemic stroke? Difficulty in understanding key issues, believing risks of treatment outweigh benefits of medication, and the belief that risk goes away once treated are all common barriers to patient education about their potential treatment options to reduce the risk of AFib-related stroke.  One in five physicians (21%) believe the primary barrier to educating Atrial Fibrillation patients about treatment options is the feeling that the risks outweigh the benefits for medications reducing the risk of AFib-related stroke, and nearly two in five (37%) view it as a barrier overall.  One in five physicians (19%) believe the primary barrier to educating Atrial Fibrillation patients about treatment options is they have trouble understanding what physicians are trying to explain to them, and two in five (39%) view it as a barrier overall.  Nearly one in six physicians (16%) believe the primary barrier to educating Atrial Fibrillation patients about treatment options is they think that once their symptoms are being treated, the risk of AFib-related stroke goes away, and more than one in three (36%) view it as a barrier overall.

www. russellresearch.com 33 Resources Would Like At Disposal To Discuss Stroke Risk and Treatment Options With Patients Detailed Findings: Physicians Base: Total Respondents (n=507) 16. What resources would you like to have to discuss stroke risk and treatment options with your Atrial Fibrillation patients/caregivers? The vast majority of physicians would like to have educational materials to discuss stroke risk and treatment options with patients.  Three in four physicians (76%) would like to have educational brochures, pamphlets, or posters as resources to discuss stroke risk and treatment options with their Atrial Fibrillation patients and caregivers.  More than two in five physicians (44%) would like to have web-based illustrations or animations as resources to discuss stroke risk and treatment options with their Atrial Fibrillation patients and caregivers.  One in three physicians (33%) would like to have interactive videos as a resource to discuss stroke risk and treatment options with their Atrial Fibrillation patients and caregivers.  One in four physicians (25%) would like to have on-demand FAQs as a resource to discuss stroke risk and treatment options with their Atrial Fibrillation patients and caregivers.

www. russellresearch.com 34 Atrial Fibrillation Statement Agreement Detailed Findings: Physicians Base: Total Respondents (n=507) 17. How much do you agree or disagree with each of the following statements in terms of treatment of Atrial Fibrillation? Physicians see devastating outcomes from ischemic stroke and see Atrial Fibrillation patients underestimate or live in denial about their risk. Further, many physicians believe their colleagues are not doing enough to educate about these risks, and would like more information themselves.  Virtually all physicians (97%) agree that AFib-related ischemic stroke can have devastating outcomes.  Nine in ten physicians (90%) agree that many Atrial Fibrillation patients underestimate the impact an AFib-related stroke could have on their everyday lives.  More than four in five physicians (83%) wish they had more information/educational materials to share with their Atrial Fibrillation patients that discuss stroke risk associated with Atrial Fibrillation.  Four in five physicians (79%) believe many AFib patients are in denial about their risk of experiencing an ischemic stroke and four in five (79%) believe too many underestimate the importance of adhering to their prescribed therapy for reducing the risk of AFib-related ischemic stroke.  Three in four physicians (76%) regularly advise or remind their colleagues of the increased risk for ischemic stroke among Atrial Fibrillation patients, and two in three (67%) feel many of their colleagues don't do enough to educate Atrial Fibrillation patients about the risks of AFib-related ischemic stroke.

www. russellresearch.com 35 Detailed Findings: Physicians Base: Total Respondents (n=507) Specialty Total Cardio- logist Electro- physico- logist Neuro- logist PCP/ Internal/ Family Total Respondents(507) (202) (101)(53)(151) % %% Male 8491897475 Female 169112625 Mean Age 4748474546 Primary Care/Internal Medicine/Family Practice (net) 30---100 Primary care physician 7---23 Internal medicine 7---23 Family practice 16---55 Cardiologist 40100--- Electrophysiologist 20-100-- Neurologist 10--100- Years In Practice Less than 1 to 9 years 33 364525 10 to 19 years 3733353047 20 or more years 3034302528 Mean # AFib Patients Treat 13517911891105 Mean % of Time In Clinical Practice 94 92 97 Board-certified 9798979197 Board-eligible 32393 Mean Patient Age 6263 6260 Primary Work Location Private practice 6463414985 Hospital 3336514912 Skilled nursing facility; LTAC 112-- Other 2-523 Stroke Center Affiliation Joint Commission certified comprehensive stroke center 49-- - Joint Commission certified primary stroke center 42-- - CARF - certified stroke center 4--4- None of the above 17-- - Physician Profile NPCEPNPCE CNENPCEN NNCPPP PE PCENCC

www. russellresearch.com 36 Detailed Findings: Patients

www. russellresearch.com 37 Type & Number of Strokes Experienced Detailed Findings: Patients E. What type of stroke did you experience? F. In total, how many strokes have you experienced? Mean: 2 Base: Total Stroke Survivors (n=251) Ischemic strokes are most common and a considerable percentage of survivors experience multiple strokes.  A slight majority of survivors (53%) have experienced an ischemic stroke.  One in six caregivers (16%) indicate the person in their care has experienced a hemorrhagic stroke.  More than one in three survivors (35%) have experienced a Transient Ischemic Attack (TIA).  Nearly two in five survivors (37%) have experienced multiple strokes.

www. russellresearch.com 38 How Long Ago Most Recent Stroke Took Place Detailed Findings: Patients Base: Total Stroke Survivors (n=251) G. How long ago did your most recent stroke take place? Mean: 3.6 years Most survivors experienced a stroke less than 5 years ago.  Seven in ten survivors (69%) experienced their most recent stroke less than 5 years ago.  One in seven survivors (14%) experienced their most recent stroke less than 1 year ago.

www. russellresearch.com 39 Time And Activities Where Assistance Is Required Detailed Findings: Patients Base: Total Stroke Survivors (n=251) H.When it comes to everyday activities (such as bathing, dressing, or toileting), keeping in mind you may need more help in some areas, on average what percentage of the time do you need assistance? I. For what type(s) of everyday activities do you need assistance at least some of the time? Base: Total Stroke Survivors Needing Assistance (n=99) Mean: 12% While a majority of survivors don’t require assistance, those who do usually need it for activities outside of the home.  Two in five survivors (39%) require assistance in everyday activities.  One in two survivors who require assistance (51%) need assistance with driving.  One in two survivors who require assistance (49%) need assistance with shopping.  Two in five survivors who require assistance (41%) need assistance with moving/mobility.  More than one in three survivors who require assistance (36%) need assistance with taking medication.

www. russellresearch.com 40 Activities Experienced Difficulty Within First 6 Months Following Stroke Detailed Findings: Patients J. Did you experience difficulty or limitations with any of the following in the first six months OR as a result of your stroke? Total Total Stroke Survivors(251) % Experienced Limitations (net) 88 Motor (subnet) 81 Impaired balance 56 Walking 51 Speech 46 Hand movement 44 Leg movement 39 Arm movement 37 Affect (subnet) 60 Depression or sadness 45 Insomnia 29 Loss of appetite 20 Uncontrollable laughing or crying 20 Sensory (subnet) 54 Numbness 39 Tingling 30 Pain 28 Cognition (subnet) 52 Memory 45 Maintaining attention 31 Calculation abilities 19 Language (subnet) 33 Writing 27 Reading 22 Vision (subnet) 31 Impaired vision 26 Blindness 6 Other 3 Incontinence 18 Other 2 No limitations 12 Motor limitations, along with depression and memory issues, are the most common difficulties in the first six months following a stroke.  Four in five survivors (81%) indicate they experienced one or more motor limitations within the first 6 months of suffering a stroke.  More than one-half of survivors (56%) experienced impaired balance within the first 6 months of suffering a stroke.  One in two survivors (51%) experienced walking limitations within the first 6 months of suffering a stroke.  Nearly one-half of survivors (45%) experienced depression or sadness within the first 6 months of suffering a stroke.  Nearly one-half of survivors (45%) experienced memory issues within the first 6 months of suffering a stroke.

www. russellresearch.com 41 Motor Limitations Currently Experience Detailed Findings: Patients Base: Total Stroke Survivors Who Have Experienced Motor Limitations (n=204) K. You {mentioned/indicated} that you had experienced motor limitations as a result of your stroke. Which of the following limitations, if any, are you still experiencing? Motor limitations, and specifically balance issues, persist beyond the initial months of suffering a stroke.  Four in five survivors who initially experienced motor limitations (80%) continue to suffer from them.  One-half of survivors who initially experienced motor limitations (51%) continue to suffer from impaired balance.  Nearly two in five survivors who initially experienced motor limitations (37%) continue to suffer from walking limitations.  Nearly two in five survivors who initially experienced motor limitations (37%) continue to suffer from hand movement limitations.

www. russellresearch.com 42 Awareness of Atrial Fibrillation Prior To Stroke Detailed Findings: Patients Base: Total Stroke Survivors (n=251) 1a. Did you know that you had Atrial Fibrillation prior to experiencing a stroke? Most survivors did not know they had Atrial Fibrillation prior to experiencing a stroke.  Two in five survivors (39%) knew they suffered from Atrial Fibrillation prior to experiencing a stroke.  Three in five survivors (61%) did not know they suffered from Atrial Fibrillation prior to experiencing a stroke.

www. russellresearch.com 43 How Life Has Changed Since Atrial Fibrillation Diagnosis Detailed Findings: Patients Base: Total Respondents (n=499) 1b. How has your life changed, or what are you doing differently, since you were diagnosed with Atrial Fibrillation? Atrial Fibrillation Only Stroke Survivors Total Respondents(248)(251) % Has Changed (net) 8589 Getting healthier – more exercise, eating right 5258 Do everything I can to learn about reducing my risk of stroke due to Atrial Fibrillation 4653 Do everything I can to learn about Atrial Fibrillation 4843 Don't go out as much 1335 Afraid to exercise or do other strenuous activity 1724 Joined a support group 415 Taking medications 22 No changes 1511 A slight majority of AFib patients have attempted to become more healthy since diagnosis, however survivors are more likely to stay in more and join a support group.  More than one in two Atrial Fibrillation patients (55%) have attempted to get healthier since being diagnosed.  One in two Atrial Fibrillation patients (49%) indicate they have done everything they can to learn about reducing their risk of stroke due to Atrial Fibrillation since being diagnosed.  More than two in five Atrial Fibrillation patients (45%) indicate they have done everything they can to learn about Atrial Fibrillation since being diagnosed.  Stroke survivors (35%) are nearly three times as likely as AFib-only patients (13%) to indicate they don’t go out as much since being diagnosed.  One in seven stroke survivors (15%) have joined a support group since being diagnosed with Atrial Fibrillation, a significantly higher percentage when compared to AFib-only patients (4%).

www. russellresearch.com 44 Conditions Think Individual with Atrial Fibrillation Would Be At Increased Risk For Experiencing Detailed Findings: Patients Base: Total Respondents (n=499) 2. Which, if any, of the following conditions do you think a person with Atrial Fibrillation would be at an increased risk for experiencing? Atrial Fibrillation Only Stroke Survivors Total Respondents (248)(251) % Stroke7881 Irregular heartbeat8571 Heart palpitations7257 Heart attack4553 Difficulty breathing/ shortness of breath 5443 High blood pressure4152 Chronic fatigue4251 Fainting4333 Sleep apnea2730 None of the above16 Most Atrial Fibrillation patients understand there is an increased risk of stroke, regardless of whether they’ve experienced one in the past.  Four in five Atrial Fibrillation patients (80%) believe a person with Atrial Fibrillation would be at an increased risk of stroke.  Nearly four in five Atrial Fibrillation-only patients (78%) believe a person with Atrial Fibrillation would be at an increased risk of stroke  Stroke survivors are significantly more likely than AFib-only patients to believe a person with Atrial Fibrillation would be at increased risk of high blood pressure (52% vs. 41%) and chronic fatigue (51% vs. 42%).  AFib-only patients are significantly more likely than stroke survivors to believe a person with Atrial Fibrillation would be at increased risk of irregular heartbeat (85% vs. 71%), heart palpitations (72% vs. 57%), difficulty breathing (54% vs. 43%), and fainting (43% vs. 33%).

www. russellresearch.com 45 Conditions Physician Indicated At Increased Risk For Experiencing As Result Of Atrial Fibrillation Detailed Findings: Patients Base: Total Respondents (n=499) 3. When you were first diagnosed with Atrial Fibrillation, which, if any, of the following did your physician indicate you may be at an increased risk for experiencing as a result of Atrial Fibrillation? Atrial Fibrillation Only Stroke Survivors Total Respondents(248) (251) % Stroke6167 Irregular heartbeat6450 Heart palpitations4333 Heart attack2737 High blood pressure1934 Difficulty breathing/ shortness of breath 2823 Chronic fatigue1426 Fainting1817 Sleep apnea1416 None of the above414 A considerable percentage of Atrial Fibrillation patients were not informed by a physician of their increased risk of stroke.  Nearly two in three Atrial Fibrillation patients (64%) were informed by a physician that they may be at increased risk of stroke as a result of Atrial Fibrillation – more than one-third (36%) were not informed.  Nearly three in five Atrial Fibrillation patients (57%) were informed by a physician that they may be at increased risk of irregular heartbeat as a result of Atrial Fibrillation.  Atrial Fibrillation-only patients are significantly more likely than stroke survivors to indicate they were informed of an increased risk of irregular heartbeat (64% vs. 50%) and heart palpitations (43% vs. 33%) as a result of Atrial Fibrillation.  Stroke survivors are significantly more likely than Atrial Fibrillation-only patients to indicate they were informed of an increased risk of heart attack (37% vs. 27%), high blood pressure (34% vs. 19%) and chronic fatigue (26% vs. 14%) as a result of Atrial Fibrillation.

www. russellresearch.com 46 Condition Concern Detailed Findings: Patients Base: Total Respondents (n=499) 4a. How concerned are you in terms of experiencing any of the following as a result of Atrial Fibrillation? Atrial Fibrillation Only Stroke Survivors Total Respondents(248) (251) % Stroke8186 Irregular heartbeat8162 Heart attack7264 Heart palpitations7253 Difficulty breathing/ shortness of breath 6650 High blood pressure5857 Chronic fatigue56 Fainting5136 Sleep apnea4236 Most Atrial Fibrillation patients are concerned about experiencing a stroke, while AFib-only patients have a wider range of concerns than stroke survivors.  More than four in five Atrial Fibrillation patients (84%) are concerned about stroke as a result of Atrial Fibrillation.  More than seven in ten Atrial Fibrillation patients (72%) are concerned about irregular heartbeat as a result of Atrial Fibrillation.  Atrial Fibrillation-only patients are significantly more likely than stroke survivors to be concerned about irregular heartbeat (81% vs. 62%), heart palpitations (72% vs. 53%), difficulty breathing/shortness of breath (66% vs. 50%), and fainting (51% vs. 36%) as a result of Atrial Fibrillation.

www. russellresearch.com 47 Ways Life Has Changed Since Having A Stroke Detailed Findings: Patients Base: Total Stroke Survivors (n=251) 4b. How has your life changed, or what are you doing differently, since having a stroke? Although many survivors experience negative emotional consequences, a majority aim for positive change.  Three in five stroke survivors (60%) are getting healthier since having a stroke.  One in two stroke survivors (48%) are doing everything they can to learn about Atrial Fibrillation since experiencing a stroke.  Two in five stroke survivors (40%) don’t go out as much since experiencing a stroke.  Two in five stroke survivors (39%) have experienced depression since experiencing a stroke.

www. russellresearch.com 48 Stroke Type Familiarity Detailed Findings: Patients Base: Total Respondents (n=499) 5a. How familiar are you with the term Ischemic Stroke? 5b. How familiar are you with the term Hemorrhagic Stroke? 5c. How familiar are you with the term Transient Ischemic Attack (TIA)? A slight majority of AFib patients are familiar with ischemic stroke.  More than one in two survivors (55%) indicate familiarity with ischemic stroke.  One in two survivors (51%) indicate familiarity with hemorrhagic stroke.  Two in three survivors (65%) indicate familiarity with Transient Ischemic Attack (TIA). 55 51 65 IHHHTT

www. russellresearch.com 49 Stroke Type Familiarity Detailed Findings: Patients Base: Total Respondents (n=499) 5a. How familiar are you with the term Ischemic Stroke? 5b. How familiar are you with the term Hemorrhagic Stroke? 5c. How familiar are you with the term Transient Ischemic Attack (TIA)? Most Atrial Fibrillation-only patients are not familiar with ischemic stroke.  More than three in five AFib-only patients (62%) are not familiar with ischemic stroke.  More than three in five AFib-only patients (62%) are not familiar with hemorrhagic stroke.  Stroke survivors are significantly more likely than Atrial Fibrillation-only patients to be familiar with transient ischemic stroke (TIA) (78% vs. 51%), ischemic stroke (72% vs. 38%), and hemorrhagic stroke (63% vs. 38%). 72 63 78 == Ischemic === Hemorrhagic ===== TIA ==== 5138

www. russellresearch.com 50 Stroke Type Identification: Obstruction Within Blood Vessel Supplying Blood to the Brain Detailed Findings: Patients Base: Total Respondents (n=499) 5d. To the best o f your knowledge, which type of stroke occurs as a result of an obstruction (i.e., clot or blockage) within a blood vessel supplying blood to the brain? Most Atrial Fibrillation-only patients are unaware of the definition of ischemic stroke.  Overall, two-fifths of Atrial Fibrillation patients (42%) correctly identified an ischemic stroke as being caused by an obstruction within a blood vessel supplying blood to the brain.  Less than three in ten AFib-only patients (28%) correctly identified an ischemic stroke as being caused by an obstruction within a blood vessel supplying blood to the brain.  Stroke survivors were significantly more likely than Atrial Fibrillation-only patients to properly identify ischemic stroke (55% vs. 28%). Atrial Fibrillation Only Stroke Survivors Total Respondents (248)(251) % Ischemic Stroke2855 Transient Ischemic Attack (TIA) 1314 Hemorrhagic Stroke1511 Don't know/not sure4421

www. russellresearch.com 51 Stroke Type Identification: Ruptured Blood Vessel That Bleeds Into Surrounding Brain Detailed Findings: Patients 5e. To the best of your knowledge, which type of stroke occurs as a result of a weakened blood vessel that ruptures and bleeds into the surrounding brain? AFib-only patients are more likely to be able to correctly identify hemorrhagic stroke.  Two in three Atrial Fibrillation patients (66%) correctly identified a hemorrhagic stroke as being the result of a ruptured blood vessel that bleeds into the surrounding brain.  Three in four stroke survivors (75%) correctly identified a hemorrhagic stroke as being the result of a ruptured blood vessel that bleeds into the surrounding brain.  Nearly three in five Atrial Fibrillation-only patients (58%) correctly identified a hemorrhagic stroke as being the result of a ruptured blood vessel that bleeds into the surrounding brain.  Stroke survivors were significantly more likely than Atrial Fibrillation-only patients to properly identify hemorrhagic stroke (75% vs. 58%). Base: Total Respondents (n=499) Atrial Fibrillation Only Stroke Survivors Total Respondents (248)(251) % Hemorrhagic Stroke5875 Transient Ischemic Attack (TIA) 77 Ischemic Stroke34 Don't know/not sure3215

www. russellresearch.com 52 Stroke Type Believed To Occur Most Often In AFib Patients Detailed Findings: Patients Base: Total Respondents (n=499) 5f. In AFib, which type of stroke do you think occurs more often? A majority of patients were unable to identify ischemic stroke as the most common type of stroke.  Two in five Atrial Fibrillation patients (41%) believe ischemic stroke occurs most often in people diagnosed with Atrial Fibrillation.  Three in ten Atrial Fibrillation patients (31%) are unsure what type of stroke occurs most often in people diagnosed with Atrial Fibrillation.

www. russellresearch.com 53 Prior Awareness of Different Stroke Types Detailed Findings: Patients Base: Total Respondents (n=499) 5g. Prior to today, were you aware there were different types strokes? AFib-only patients are less knowledgeable than survivors in terms of stroke types.  Overall, two in three Atrial Fibrillation patients (65%) indicated prior awareness of different types of strokes.  Stroke survivors are significantly more likely to be aware of the existence of different types of strokes (74% vs. 55% of Atrial Fibrillation-only patients).

www. russellresearch.com 54 Future Stroke Concern Detailed Findings: Patients Base: Total Respondents (n=499) 6a. How concerned are you that you might experience an AFib-related Ischemic Stroke in the future? 6c. How concerned are you that you might experience a Hemorrhagic Stroke in the future? 6e. How concerned are you that you might experience an AFib-related Transient Ischemic Attack (a mini-stroke) in the future? Most patients are concerned about experiencing a stroke in the future.  Three in four Atrial Fibrillation patients (76%) are concerned they might experience an ischemic stroke in the future.  Three in four Atrial Fibrillation patients (75%) are concerned they might experience a Transient Ischemic Attack (TIA) in the future.  Two in three Atrial Fibrillation patients (65%) are concerned they might experience a hemorrhagic stroke in the future. Atrial Fibrillation Only Stroke Survivors Total Respondents (248)(251) % Ischemic stroke76 Transient Ischemic Attack 7675 Hemorrhagic stroke6763

www. russellresearch.com 55 Interest In Learning More About Reducing Risk Of Stroke Detailed Findings: Patients Base: Total Respondents (n=499) 6b. How interested would you be in learning more about how to reduce your risk of an AFib-related Ischemic Stroke? 6d. How interested would you be in learning more about how to reduce your risk of a Hemorrhagic Stroke? 6f. How interested would you be in learning more about how to reduce your risk of an AFib-related Transient Ischemic Attack (a mini-stroke)? Patients want to learn more about reducing risk of all types of stroke.  More than four in five Atrial Fibrillation patients (82%) are interested in learning more about reducing the risk of ischemic stroke.  More than four in five Atrial Fibrillation patients (82%) are interested in learning more about reducing the risk of Transient Ischemic Attack.  Three in four Atrial Fibrillation patients (76%) are interested in learning more about reducing the risk of hemorrhagic stroke.  A significantly higher percentage of Atrial Fibrillation-only patients are interested in learning more about reducing the risk of Transient Ischemic Attack (86% vs. 78% of survivors) and hemorrhagic stroke (83% vs. 69%). Atrial Fibrillation Only Stroke Survivors Total Respondents (248)(251) % Ischemic stroke8579 Transient Ischemic Attack 8678 Hemorrhagic stroke8369

www. russellresearch.com 56 Primary Concern About Having A Stroke Detailed Findings: Patients Base: Total Respondents (n=499) 6g. What concerns you most about having a stroke? Motor limitations and loss of independence concern patients most when it comes to experiencing a stroke.  One-third of Atrial Fibrillation patients (32%) indicate their primary concern about having a stroke is losing the ability to move, talk, or some other physical function.  Two in five Atrial Fibrillation-only patients (40%) indicate their primary concern about having a stroke is losing the ability to move, talk, or some other physical function, significantly higher than stroke survivors (24%).  One in five stroke survivors (20%) indicate their primary concern about having a stroke is loss of independence, significantly higher than AFib-only patients (13%).  One in seven Atrial Fibrillation patients (15%) indicate their primary concern about having a stroke is being dependent on someone else.

www. russellresearch.com 57 Whether Physician Ever Discussed Increased Risk of Stroke Due To Atrial Fibrillation Detailed Findings: Patients Base: Total Not Told Of Increased Stroke Risk (n=179) 7. Has your physician ever discussed with you the increased risk of stroke due to Atrial Fibrillation? A majority of Atrial Fibrillation patients not initially told of an increased stroke risk were eventually informed by their physician.  Nearly three in five patients who were not told of an increased stroke risk (58%) have had a discussion with their physician about their increased risk of stroke due to Atrial Fibrillation.  More than three in five stroke survivors who were not told of an increased stroke risk (63%) have had a discussion with their physician about their increased risk of stroke due to Atrial Fibrillation.  More than one in two AFib-only patients who were not told of an increased stroke risk (53%) have had a discussion with their physician about their increased risk of stroke due to Atrial Fibrillation.  Overall, more than four in five Atrial Fibrillation patients (85%) have had a discussion with their physician about their increased risk of stroke due to Atrial Fibrillation. Total %85%82%88%

www. russellresearch.com 58 Atrial Fibrillation Stroke Treatment Conversation Initiation Detailed Findings: Patients Base: Total Ever Discussed Increased Stroke Risk With Doctor (n=423) 8. Thinking about conversations you have had with your physician about increased risk of AFib-related stroke and available treatments to reduce the risk of AFib-related stroke, what percentage of the time would you say conversations are initiated by you versus those initiated by your physician? Patients believe there is a near equal initiation of conversation with physicians regarding increased risk of Atrial Fibrillation-related stroke and available treatments.  On average, patients indicate they initiate nearly one-half (47%) of conversations about increased risk of AFib-related stroke and available treatments to reduce the risk of AFib-related stroke.  On average, patients indicate physicians initiate a slight majority (53%) of conversations about increased risk of AFib-related stroke and available treatments to reduce the risk of AFib-related stroke. Atrial Fibrillation Only Stroke Survivors Total Discussed Increased Risk Of Stroke With Doctor (203) (220) % Initiated by physician5650 Initiated by patient4450

www. russellresearch.com 59 Ways Physician Has Discussed Specifics of Atrial Fibrillation & Increased Risk Of Atrial Fibrillation-Related Stroke Detailed Findings: Patients 9a. In which, if any, ways has your physician discussed the specifics of your condition and increased risk of AFib-related stroke? Direct discussion and written materials are the most common form of education by physicians about increased risk of AFib-related stroke.  Six in seven Atrial Fibrillation patients (87%) indicate their physician has discussed their situation with them directly.  Less than one-half of patients (48%) indicate their physician gave them written materials to read regarding Atrial Fibrillation and the increased risk of AFib-related stroke.  One in four Atrial Fibrillation patients (25%) indicate a nurse, educator, or other professionals in their physician’s office has discussed their situation with them. Base: Total Discussed With Doctor Increased Risk of Stoke (n=423)

www. russellresearch.com 60 Level Of Satisfaction With Information Provided By Physician Detailed Findings: Patients 9b. Overall, how satisfied were you with the information provided by your physician about your condition and increased risk of AFib- related stroke? Were you… Atrial Fibrillation patients are mostly satisfied with the information that was provided to them by their physician.  Nine in ten patients (89%) are satisfied with the information provided by their physician about their condition and increased risk of AFib-related stroke.  More than nine in ten AFib-only patients (93%) are satisfied with the information provided by their physician about their condition and increased risk of AFib-related stroke, significantly higher than the level of satisfaction among stroke survivors (86%). Base: Total Discussed With Doctor Increased Risk of Stoke (n=423) 89 8693

www. russellresearch.com 61 Information Sources Would Like Physician To Provide More Often Detailed Findings: Patients 9c. Which of the following would you like more of from your physician on the specifics of your condition and increased risk of AFib- related stroke? Among patients who are dissatisfied with provided information or those who have not discussed their situation with physicians, direct discussion and written materials are both wanted.  Three in five Atrial Fibrillation patients who are dissatisfied with provided information or have not discussed their increased risk of stroke with physicians (62%) would like to discuss their situation directly with their physician.  Stroke survivors (71%) are significantly more likely than Atrial Fibrillation- only patients (53%) to want to speak with their doctor directly.  More than one in two Atrial Fibrillation patients who are dissatisfied with provided information or have not discussed their increased risk of stroke with physicians (55%) want written materials to read. Base: Total Not Satisfied With Information/Have Not Discussed With Doctor (n=122)

www. russellresearch.com 62 Topics of Discussion With Physician Regarding Atrial Fibrillation-Related Stroke Detailed Findings: Patients 10. Has your physician ever discussed with you any of the following regarding stroke? A majority of stroke survivors who spoke with a physician about increased risk of stroke never had a discussion regarding their risk with and without medication.  Less than one in two stroke survivors who spoke with their physician about Atrial Fibrillation (48%) discussed the risk of stroke with and without medication.  Two in three AFib-only patients who spoke with their physician about Atrial Fibrillation (65%) discussed the risk of stroke with and without medication – significantly higher than for stroke survivors.  One in two stroke survivors who spoke with their physician about Atrial Fibrillation (50%) discussed the symptoms of AFib-related stroke – significantly higher than for AFib-only patients (35%). Base: Total Discussed Increased Risk Of Stroke With Doctor (n=423)

www. russellresearch.com 63 Prevention of ischemic stroke is the most widely cited quality in treatment.  Two in five patients who discussed an increased stroke risk with physicians (39%) named using a treatment that reduces the risk of a stroke caused by a blood clot in the brain to be the most important quality, and three in five (59%) named it as one of their two most important qualities.  More than one in five patients who discussed an increased stroke risk with physicians (22%) named using a treatment which causes the least side effects to be the most important quality, and more than two in five (43%) named it as one of their two most important qualities.  One in seven patients who discussed an increased stroke risk with physicians (14%) named using a treatment that minimizes the risk of a stroke caused by a bleed in the brain to be the most important quality, and two in five (40%) named it as one of their two most important qualities. Most Important Qualities In Treatment Designed To Reduce Risk Of Stroke From Atrial Fibrillation Detailed Findings: Patients 11a. When discussing treatment options to reduce your risk of stroke in atrial fibrillation with your doctor, which of the following is most important to you? 11b. And when discussing treatment options to reduce your risk of stroke in atrial fibrillation with your doctor, which of the following is second most important to you? Base: Total Discussed Increased Stroke Risk With Doctor (n=423)

www. russellresearch.com 64 Whether Ever Taken Medications And Types Prescribed To Reduce Risk Of Atrial Fibrillation-Related Stroke Detailed Findings: Patients 12. Has your physician ever had you take medications to reduce the risk of AFib-related stroke? 13a. To the best of your knowledge, what type(s) of treatment options has your physician prescribed in order to reduce the risk of AFib-related stroke? Most patients who have discussed AFib-related stroke with their physician has taken oral anticoagulants for treatment.  Six in seven patients who have discussed Atrial Fibrillation-related stroke with their physician (87%) have taken medication to reduce their risk of stroke.  More than seven in ten patients who have taken medication to reduce their risk of AFib-related stroke (72%) have been prescribed an oral anticoagulant.  One in two patients who have taken medication to reduce their risk of AFib- related stroke (49%) have been prescribed an antiplatelet. Base: Total Have Taken Medication (n=369) Base: Total Discussed Atrial Fibrillation- Related Stroke Risk With Doctor (n=423)

www. russellresearch.com 65 Whether Regularly Takes Prescribed Treatment Detailed Findings: Patients Base: Total Have Taken Medication (n=369) 13b. Do you regularly take the treatment prescribed by your doctor? The vast majority of Atrial Fibrillation patients that have taken medication are compliant, with AFib-only patients comprising the small percentage who are not taking their medication.  More than nine in ten patients who have taken medication (92%) regularly take their prescribed treatment to reduce their risk of AFib-related stroke.  Atrial Fibrillation-only patients are significantly more likely than stroke survivors to have stopped taking their prescribed treatment (9% vs. 4%).

www. russellresearch.com 66 Gender Believe Has Higher Risk Of Atrial Fibrillation-Related Stroke & Whether Able To Describe Most Common Symptoms Detailed Findings: Patients Base: Total Respondents (n=499) 14.Who do you think has a higher risk of experiencing an AFib-related stroke? 15. If asked, do you believe that you would be able to describe to someone the most common symptoms of a stroke? A considerable percentage of AFib-only patients could not describe the most common stroke symptoms.  One in three Atrial Fibrillation-only patients (32%) feel they are not able to describe the common symptoms of stroke.  Nearly nine in ten stroke survivors (88%) feel they are able to describe the common symptoms of stroke. Few Atrial Fibrillation patients know that women at are at higher risk of Atrial Fibrillation-related stroke.  More than one in four Atrial Fibrillation patients (27%) believe women have a higher risk of experiencing an AFib-related stroke. Survivors (31%) are significantly more likely than AFib-only patients (23%) to believe women are at greater risk.  One in four patients (24%) believe men have a higher risk of experiencing an AFib-related stroke.  One-half of patients (49%) do not believe either gender has a higher risk of experiencing an AFib-related stroke.

www. russellresearch.com 67 Symptoms Of Stroke Detailed Findings: Patients 16a. To the best of your knowledge, which, if any, of the following are symptoms of someone experiencing a stroke? Base: Total Respondents (n=499) Speaking and loss of movement are the most widely thought symptoms of stroke.  Nine in ten Atrial Fibrillation patients (89%) believe sudden trouble speaking is a symptom of someone experiencing a stroke.  Six in seven Atrial Fibrillation patients (86%) believe sudden numbness/ tingling/weakness/loss of movement in face/arm/leg, especially on one side of the body is a symptom of someone experiencing a stroke.  Four in five Atrial Fibrillation patients (81%) believe sudden problems with walking or balance is a symptom of someone experiencing a stroke.  Four in five Atrial Fibrillation patients (80%) believe sudden confusion or trouble understanding simple statements is a symptom of someone experiencing a stroke.

www. russellresearch.com 68 Potential Outcomes After Having A Stroke Detailed Findings: Patients 16b. To the best of your knowledge, which, if any, of the following are possible outcomes after a stroke? Base: Total Respondents (n=499) Several potential negative outcomes are widely seen as possible after experiencing a stroke.  About four in five Atrial Fibrillation patients believe an inability to speak (82%), paralysis (80%), balance issues (80%), problems thinking (79%) and memory loss (78%) are possible outcomes after having a stroke.  More than three in four Atrial Fibrillation patients (77%) believe death is a possible outcome after having a stroke.

www. russellresearch.com 69 Potential Outcomes After Having A Stroke Detailed Findings: Patients 16b. To the best of your knowledge, which, if any, of the following are possible outcomes after a stroke? Stroke survivors see a far wider range of potential negative outcomes compared to Atrial Fibrillation-only patients.  Virtually every potential outcome after a stroke was cited by a significantly higher percentage of stroke survivors.  The largest gaps in perception were sleep disorders (59% survivors vs. 23% AFib-only patients), sudden/unpredicted episodes of crying/laughing (55% vs. 24%), fatigue (73% vs. 43%), pain (55% vs. 29%), inability to control urine or bowels (67% vs. 43%), and impulse control (52% vs. 30%). Base: Total Respondents (n=499)

www. russellresearch.com 70 Atrial Fibrillation-Only Statement Agreement Detailed Findings: Patients 17. How much do you agree or disagree with each of the following statements? Base: Atrial Fibrillation Patients Only (n=248) Virtually all Atrial Fibrillation-only patients would do whatever is needed to reduce their risk of AFib-related stroke, and most would like more information.  More than nine in ten AFib-only patients (92%) would do whatever their physician tells them in order to reduce the risk of an AFib-related stroke.  More than nine in ten AFib-only patients (92%) indicate it would not matter to them whether they had to take a treatment once or twice a day if it reduced the risk of stroked caused by a blood clot in the brain.  More than nine in ten AFib-only patients (92%) indicate that if a treatment that reduced their risk of AFib-related stroke required regular visits to their physician, they would do it (92%).  Four in five AFib-only patients (80%) would like to have more information to take charge of their Atrial Fibrillation and learn about reducing the risk of AFib-related stroke.

www. russellresearch.com 71 Atrial Fibrillation Fact Awareness (Previously Aware) Detailed Findings: Patients 18. I will now read you a list of facts about Atrial Fibrillation. Please tell me whether you were previously aware or not previously of these facts. An alarming number of Atrial Fibrillation patients do not understand the severity of AFib-related strokes.  More than two in three Atrial Fibrillation patients (68%) were not previously aware that AFib-related strokes are nearly twice as likely to be fatal or disabling as non-AFib-related strokes.  Nearly two in three Atrial Fibrillation patients (64%) were previously aware that you can have 5 times greater risk for stroke if you are living with untreated Atrial Fibrillation.  Nearly three in five Atrial Fibrillation patients (58%) were previously aware that the majority of AFib-related strokes are caused by a blood clot in the brain. Base: Total Respondents (n=499)

www. russellresearch.com 72 Stroke Statement Agreement Detailed Findings: Patients 19. How much do you agree or disagree with each of the following statements? Base: Total Stroke Survivors (n=251) Stroke survivors underestimated the impact an AFib-related stroke could have on their lives.  Five in six stroke survivors (83%) wish they had known more about reducing the risk of an AFib-related stroke prior to experiencing a stroke.  More than three in four stroke survivors (77%) agree that their life has not been the same since experiencing an AFib-related stroke.  Nearly three in four survivors (73%) agree that experiencing a stroke was worse than they had imagined.  Three in five stroke survivors (60%) sometimes feel like they are a burden to others since experiencing an AFib-related stroke.  More than three in five stroke survivors (63%) believe that there was not enough information on reducing the risk of AFib-related stroke provided to them when they was initially diagnosed with Atrial Fibrillation.

www. russellresearch.com 73 Life Changes Experienced Since Stroke Detailed Findings: Patients 20. You {mentioned/indicated} that your life has not been the same since experiencing an AFib-related stroke. In which, if any, of the following ways has your life changed? Base: Total Agree Life Has Changed Since Stroke (n=194) Activities previously done outside of the home are most often affected post-stroke.  Among survivors who indicated their life has not been the same, more than one-half (56%) indicate they can no longer do activities or hobbies that bring them joy.  Among survivors who indicated their life has not been the same, more than two in five (44%) indicate they had to give up my job or reduce my hours.  Among survivors who indicated their life has not been the same, two in five (40%) indicate it has been a financial burden.

www. russellresearch.com 74 Detailed Findings: Patients AFibStroke TotalOnlySurvivor Total Respondents(499)(248)(251) %% Gender Male 495049 Female 515051 Mean Age: 62.160.963.2 Primary Coordinator For Daily Home/Medical Care Self 839670 Family member 15426 Friend 1-2 Hired caregiver 102 Devices Own Mobile/cell phone 80 Desktop computer 727470 Laptop or netbook computer 707267 iPad or other tablet 464944 E-reader 292730 Devices Use To Access Health Information Desktop computer 55 Laptop or netbook computer 515349 iPad or other tablet 212220 Mobile/cell phone 171221 E-reader 417 None of the above 768 Marital Status Married 616358 Not Married (net) 393741 Patient Demographic Profile AFibStroke TotalOnlySurvivor Total Respondents(499)(248)(251) %% Education No College (net)201724 College (net)798375 Employment Status Employed (net)273321 Not Employed (net)726776 Median Household Income 57.863.751.1 Ethnic Background Caucasian868885 African-American658 Hispanic/Latino222 Native American222 Asian/Pacific Islander 121 Mixed ethnic background 101 Rather not answer112 Type Of Community Urban222124 Suburban586155 Rural191821 Census Region Northeast21 South383541 Midwest212318 West20

www. russellresearch.com 75 Detailed Findings: Caregivers

www. russellresearch.com 76 Type & Number of Strokes Experienced Detailed Findings: Caregivers Base: Total Respondents (n=203) E. What type of stroke did (he/she) experience? F. In total, how many strokes has (he/she) experienced? Ischemic strokes are the most common type experienced by survivors in the care of caregivers.  More than one in two caregivers (56%) indicate the person in their care has experienced an ischemic stroke.  One in five caregivers (20%) indicate the person in their care has experienced an hemorrhagic stroke.  One in five caregivers (19%) indicate the person in their care has experienced a Transient Ischemic Attack (TIA).  One in ten caregivers (10%) indicate the person in their care has experienced a combination of hemorrhagic and ischemic stroke.  More than one in two caregivers (55%) indicate the person in their care has experienced 1 stroke.  One in four caregivers (24%) indicate the person in their care has experienced 3 or more strokes. Mean: 2

www. russellresearch.com 77 Time of Survivor’s Most Recent Stroke Detailed Findings: Caregivers Base: Total Respondents (n=203) G. How long ago did (his/her) most recent stroke take place? Most caregivers are providing assistance to survivors who experienced a stroke less than 5 years ago.  Three in four caregivers (74%) are providing care to a survivor who experienced their most recent stroke less than 5 years ago.  One in five caregivers (20%) are providing care to a survivor who experienced their most recent stroke less than 1 year ago. Mean: 3 years

www. russellresearch.com 78 Time And Activities Where Assistance Is Required Detailed Findings: Caregivers Base: Total Respondents (n=203) H.When it comes to everyday activities (such as bathing, dressing, or toileting), keeping in mind that (he/she) may need more help in some areas, on average what percentage of the time do you have to provide assistance to (him/her)? I. For what type(s) of everyday activities do you need to provide assistance at least some of the time? Caregiving covers all aspects of a survivor’s life, and a considerable percentage of caregivers are providing assistance for nearly all everyday activities.  On average, caregivers are providing assistance to survivors during 47% of their everyday activities.  One in seven caregivers (14%) provide assistance 100% of the time survivors are doing everyday activities.  One in two caregivers (50%) provide assistance at least half of the time survivors are doing everyday activities.  More than four in five caregivers who provide assistance (83%) drive for survivors at least some of the time.  Four in five caregivers who provide assistance (79%) help with shopping for survivors at least some of the time.  Three in five caregivers who provide assistance (62%) help with bathing for survivors at least some of the time. Base: Total Provide Assistance (n=190) Mean: 47%

www. russellresearch.com 79 Activities Survivor Experienced Difficulty With In First 6 Months Following Stroke Detailed Findings: Caregivers J. Did (he/she) experience difficulty or limitations with any of the following in the first six months OR as a result of (his/her) stroke? Motor and cognitive limitations are most commonly observed by caregivers in the months immediately following a stroke.  More than nine in ten caregivers (92%) indicate the survivor in their care experienced one or more motor limitations within the first 6 months of suffering a stroke.  Four in five caregivers (81%) indicate the survivor in their care experienced one or more cognitive limitations within the first 6 months of suffering a stroke.  Impaired balance (71%), walking (70%), memory (70%), speech (60%), and arm movement (58%) are the most common limitations experienced as reported by caregivers. Total Total Respondents(203) % Experienced Limitations (net)97 Motor (subnet)92 Impaired balance71 Walking70 Speech60 Arm movement58 Hand movement55 Leg movement54 Cognition (subnet)81 Memory70 Maintaining attention45 Calculation abilities40 Affect (subnet)69 Depression or sadness56 Loss of appetite33 Insomnia30 Uncontrollable laughing or crying19 Sensory (subnet)62 Numbness39 Pain36 Tingling32 Language (subnet)59 Writing52 Reading44 Vision (subnet)43 Impaired vision37 Blindness4 Other3 Incontinence39 Other6 No limitations3

www. russellresearch.com 80 Motor Limitations Patient Currently Experiences Detailed Findings: Caregivers Base: Total With Patients Who Have Experienced Motor Limitations (n=186) K. You {mentioned/indicated} that (he/she) had experienced motor limitations as a result of (his/her) stroke. Which of the following limitations, if any, does (he/she) still experience? Impaired balance and walking are the motor limitations most likely to remain over time.  Two in three caregivers (65%) whose survivor initially experienced motor limitations continues to suffer from impaired balance.  Nearly two in three caregivers (58%) whose survivor initially experienced motor limitations continues to suffer from walking limitations.  Only six percent of caregivers whose survivor initially experienced motor limitations indicated they no longer experience any type of motor limitation.

www. russellresearch.com 81 Awareness of Patient’s Atrial Fibrillation Prior To Stroke And How Patient’s Life Has Changed Detailed Findings: Caregivers Base: Total Respondents (n=203) 1a. Did you know that (he/she) had Atrial Fibrillation prior to (his/her) experiencing a stroke? 1b. To the best of your knowledge, how has (his/her) life changed, or what is (he/she) doing differently, since (he/she) was diagnosed with Atrial Fibrillation? A slight majority of caregivers did not know the person currently in their care had Atrial Fibrillation prior to experiencing a stroke.  Less than one in two caregivers (47%) were aware the survivor in their care suffered from Atrial Fibrillation prior to experiencing a stroke.  More than two in five caregivers (43%) indicate the person in their care doesn’t go out as much since being diagnosed with Atrial Fibrillation.  Three in ten caregivers (29%) indicate the person in their care is getting healthier since being diagnosed with Atrial Fibrillation.  One in five caregivers (21%) indicate the person in their care is afraid to do exercise or other strenuous activity since being diagnosed with Atrial Fibrillation.  One in five caregivers (21%) indicate the person in their care is doing everything to learn about reducing risk of stroke due to Atrial Fibrillation since being diagnosed.

www. russellresearch.com 82 Conditions Personally Thought Individual with Atrial Fibrillation Was At Increased Risk For Experiencing Prior to Patient’s Stroke Detailed Findings: Caregivers Base: Total Respondents (n=203) 2. Prior to (his/her) experiencing a stroke, which, if any, of the following conditions did you personally think a person with Atrial Fibrillation would be at an increased risk for experiencing? Prior to the person in their care experiencing a stroke, a slight majority of caregivers believed a person with Atrial Fibrillation was at an increased risk of stroke.  More than one-half of caregivers (54%) believed Atrial Fibrillation caused an increased risk of stroke prior to the person in their care experiencing a stroke.  Two in three caregivers (65%) believed Atrial Fibrillation caused an increased risk of irregular heartbeat prior to the person in their care experiencing a stroke.  Nearly one in two caregivers (47%) believed Atrial Fibrillation caused an increased risk of heart palpitations prior to the person in their care experiencing a stroke.  More than two in five caregivers (45%) believed Atrial Fibrillation caused an increased risk of heart attack prior to the person in their care experiencing a stroke.

www. russellresearch.com 83 Conditions Physician Indicated Patient At Increased Risk For Experiencing As Result Of Atrial Fibrillation Detailed Findings: Caregivers Base: Total Respondents (n=203) 3. Prior to (his/her) experiencing a stroke, which, if any, of the following did (his/her) physician indicate (he/she) may be at an increased risk for experiencing as a result of Atrial Fibrillation? A majority of caregivers do not believe a physician informed the person in their care of the increased risk of stroke with Atrial Fibrillation.  Two in five caregivers (39%) believe the person in their care was informed of an increased risk of stroke with Atrial Fibrillation.  One in three caregivers (34%) believe the person in their care was informed of an increased risk of irregular heartbeat with Atrial Fibrillation.  However, more than one in four caregivers (28%) don’t know what the survivor in their care was told by their physician.

www. russellresearch.com 84 Condition Concern Ratings (Very/Somewhat Concerned) Detailed Findings: Caregivers Base: Total Respondents (n=203) 4a. Prior to (his/her) experiencing a stroke, how concerned was (he/she) in terms of experiencing any of the following as a result of Atrial Fibrillation? 4b. Prior to (his/her) experiencing a stroke, how concerned were you personally in terms of (him/her) experiencing any of the following as a result of Atrial Fibrillation? Most caregivers do not believe Atrial Fibrillation-related stroke was a concern of the survivor in their care, and several conditions were of more widespread concern. Caregivers often believe they were more concerned.  One in three caregivers (34%) believe that prior to their stroke, the person in their care was concerned about stroke as a result of Atrial Fibrillation, compared to more than one-half of caregivers (56%) being concerned.  Two in five caregivers (40%) believe that prior to their stroke, the person in their care was concerned about irregular heartbeat as a result of Atrial Fibrillation, compared to three in five caregivers (60%) being concerned.  Nearly two in five caregivers (38%) believe that prior to their stroke, the person in their care was concerned about high blood pressure as a result of Atrial Fibrillation, compared to one-half caregivers (50%) being concerned.  Nearly two in five caregivers (38%) believe that prior to their stroke, the person in their care was concerned about heart palpitations as a result of Atrial Fibrillation, compared to one in two caregivers (52%) being concerned.

www. russellresearch.com 85 Ways Patient’s Life Has Changed Since Having A Stroke Detailed Findings: Caregivers Base: Total Respondents (n=203) 4c. To the best of your knowledge, how has (his/her) life changed, or what is (he/she) doing differently, since having a stroke? Caregivers observe a variety of negative life changes that occur with the survivor in their care.  More than three in five caregivers (62%) indicate the survivor in their care doesn’t go out as much since having a stroke.  One in two caregivers (51%) indicate the survivor in their care has experienced depression since having a stroke.  One in four caregivers (25%) indicate the survivor in their care is afraid to exercise or do strenuous activity since having a stroke.  However, one in three caregivers (33%) indicate the survivor in their care is getting healthier since having a stroke, and one in six (16%) indicate they do everything they can to learn about strokes..

www. russellresearch.com 86 Stroke Type Familiarity Detailed Findings: Caregivers Base: Total Respondents (n=203) 5a. How familiar are you with the term Ischemic Stroke? 5b. How familiar are you with the term Hemorrhagic Stroke? 5c. How familiar are you with the term Transient Ischemic Attack (TIA)? Caregivers are mostly familiar with several different types of stroke.  Three in four caregivers (76%) are very or somewhat familiar with ischemic stroke.  Two in five caregivers (39%) are very familiar with ischemic stroke.  More than seven in ten caregivers (72%) are very or somewhat familiar with hemorrhagic stroke.  Four in five caregivers (79%) are very or somewhat familiar with Transient Ischemic Attack (TIA). 76 72 79

www. russellresearch.com 87 Stroke Type Identification Detailed Findings: Caregivers Base: Total Respondents (n=203) 5d. To the best o f your knowledge, which type of stroke occurs as a result of an obstruction (i.e., clot or blockage) within a blood vessel supplying blood to the brain? 5e. To the best of your knowledge, which type of stroke occurs as a result of a weakened blood vessel that ruptures and bleeds into the surrounding brain? Caregivers are more likely to correctly identify a hemorrhagic stroke.  More than two in three caregivers (68%) correctly identified an ischemic stroke as being caused by an obstruction within a blood vessel supplying blood to the brain.  Four in five caregivers (80%) correctly identified a hemorrhagic stroke as being the result of a ruptured blood vessel that bleeds into the surrounding brain.  One in eight caregivers (12%) incorrectly identified a hemorrhagic stroke as being caused by an obstruction within a blood vessel supplying blood to the brain. Obstruction Within Blood Vessel Supplying Blood To The Brain Ruptured Blood Vessel That Bleeds Into Surrounding Brain

www. russellresearch.com 88 Stroke Type Believe Occurs Most Often In Atrial Fibrillation Patients and Prior Awareness of Different Stroke Types Detailed Findings: Caregivers Base: Total Respondents (n=203) 5f. In AFib, which type of stroke do you think occurs more often? 5g. Prior to today, were you aware there were different types of strokes? Half of caregivers believe ischemic strokes are most common in Atrial Fibrillation patients.  One in two caregivers (51%) believe ischemic stroke occurs most often in people diagnosed with Atrial Fibrillation.  Five percent of caregivers think hemorrhagic stroke occurs most often in people diagnosed with Atrial Fibrillation.  One in six caregivers (17%) think Transient Ischemic Attack (TIA) occurs most often in people diagnosed with Atrial Fibrillation.  More than one in four caregivers (27%) don’t know what type of stroke occurs most often in people diagnosed with Atrial Fibrillation.  Nearly nine in ten caregivers (86%) indicated they were aware there were different types of strokes.

www. russellresearch.com 89 Future Stroke Concern and Interest In Learning More About Reducing The Risk Of Stroke Detailed Findings: Caregivers Base: Total Respondents (n=203) 6a. How concerned are you that (he/she) might experience an AFib-related Ischemic Stroke in the future? 6b. How interested would you be in learning more about how to reduce the risk of an AFib-related Ischemic Stroke? 6c. How concerned are you that (he/she) might experience a Hemorrhagic Stroke in the future? 6d. How interested would you be in learning more about how to reduce the risk of a Hemorrhagic Stroke? 6e. How concerned are you that (he/she) might experience an AFib-related Transient Ischemic Attack (a mini-stroke) in the future? 6f. How interested would you be in learning more about how to reduce the risk of an AFib-related Transient Ischemic Attack (a mini-stroke)? There is near universal concern that survivors will experience additional strokes in the future.  Virtually all caregivers (96%) are very or somewhat concerned the survivor in their care will experience an ischemic stroke in the future.  Virtually all caregivers (95%) are very or somewhat concerned the survivor in their care will experience a Transient Ischemic Attack in the future.  Six in seven caregivers (86%) are very or somewhat concerned the survivor in their care will experience a hemorrhagic stroke in the future.  Virtually all caregivers (95%) are very or somewhat interested in learning more about how to reduce the reduce the risk of AFib-related ischemic stroke. Very/Somewhat Concerned Very/Somewhat Interested

www. russellresearch.com 90 Patient’s Primary Concern About Having A Stroke Detailed Findings: Caregivers Base: Total Respondents (n=203) 6g. What do you think concerns (him/her) most about having a stroke? Loss of independence and physical function are believed to be the primary concerns about having a stroke.  One in three caregivers (33%) believe the loss of independence most concerns the survivor in their care about having a stroke.  Nearly one in five caregivers (18%) believe losing the ability to move, talk, or some other physical function most concerns the survivor in their care about having a stroke.  Nearly one in seven caregivers (13%) believe death most concerns the survivor in their care about having a stroke.

www. russellresearch.com 91 Whether Physician Ever Discussed Increased Risk of Stroke Due To Atrial Fibrillation With Caregiver Detailed Findings: Caregivers Base: Total Not Told Of Increased Stroke Risk (n=124) 7b. Has (his/her) physician ever discussed with you the increased risk of stroke due to Atrial Fibrillation? Caregivers typically discuss the increased risk of AFib- related stroke with physicians.  More than three in five caregivers (62%) have discussed the increased risk of stroke due to Atrial Fibrillation with the physician treating the person in their care. Base: Total Respondents (n=203)

www. russellresearch.com 92 Frequency Accompany Patient To Doctor’s Appointments Detailed Findings: Caregivers Base: Total Respondents (n=203) 8a. How often do you typically go with (him/her) to (his/her) doctor’s appointments? Virtually all caregivers are regularly going to doctor appointments.  Two in three caregivers (66%) always accompany the survivor in their care to doctor’s appointments.  Four in five caregivers (82%) accompany the survivor in their care to doctor’s appointments always or most of the time.  Only five percent of caregivers rarely or never accompany the survivor in their care to doctor’s appointments.

www. russellresearch.com 93 Atrial Fibrillation Stroke Treatment Conversation Initiation Detailed Findings: Caregivers Base: Total Attend Doctor’s Appointments Occasionally Or More Often (n=192) 8b. Thinking about conversations (he/she) has had with (his/her) physician about increased risk of AFib-related stroke and available treatments to reduce the risk of AFib-related stroke, what percentage of the time would you say conversations are initiated by (him/her) versus those initiated by (his/her) physician? Caregivers present at doctor’s appointments indicate that most conversations about AFib-related stroke and treatment options are initiated by the physician.  On average, caregivers indicated more than three in four (78%) conversations about treatments to reduce the risk of Atrial Fibrillation related stroke are initiated by the physician.  On average, caregivers indicated nearly one in four (23%) conversations about treatments to reduce the risk of Atrial Fibrillation related stroke are initiated by the physician.

www. russellresearch.com 94 Ways Physician Has Discussed Specifics of Patient’s Atrial Fibrillation & Increased Risk Of Atrial Fibrillation-Related Stroke Detailed Findings: Caregivers 8c. To the best of your knowledge, in which, if any, ways has (his/her) physician discussed the specifics of (his/her) atrial fibrillation and increased risk of AFib-related stroke? Most caregivers have seen physicians directly discuss AFib-related stroke with the survivors in their care, however not much else is done to further their education.  More than three in four caregivers who attend doctor visits (78%) indicate the survivor’s physician has directly discussed Atrial Fibrillation and the increased risk of stroke.  Nearly two in five caregivers who attend doctor visits (38%) indicate physicians have given written materials to read regarding Atrial Fibrillation or the increased risk of AFib-related stroke.  More than one in five caregivers who attend doctor visits (22%) indicate a nurse, educator, or other professional in the physician’s office has discussed their Atrial Fibrillation situation with the patient. Base: Total Attend Doctor’s Appointments Occasionally Or More Often (n=192)

www. russellresearch.com 95 Whether Researched And Where Sought Information On Atrial Fibrillation-Related Strokes And/Or Atrial Fibrillation Detailed Findings: Caregivers Base: Total Respondents (n=203) 9a. Have you personally ever researched or sought out information on AFib-related strokes and/or Atrial Fibrillation? 9b. Where specifically did you look for information on Atrial Fibrillation and/or AFib-related strokes? Caregivers usually have conducted their own research on AFib-related strokes and/or Atrial Fibrillation, using a variety of sources to educate themselves.  Seven in ten caregivers (69%) have personally sought out information related to Atrial Fibrillation or AFib-related strokes.  Of caregivers who have researched Atrial Fibrillation, more than three in four (77%) obtained information from an association or website related specifically to heart conditions or AFib-related stroke.  Of caregivers who have researched Atrial Fibrillation, more than one in two (55%) have received information directly from the survivor’s physician.  Of caregivers who have researched Atrial Fibrillation, more than one in two (54%) looked at written materials.  Of caregivers who have researched Atrial Fibrillation, three in ten (29%) have received information from a nurse, educator, or other professional. Base: Total Have Researched (n=141)

www. russellresearch.com 96 Level Of Satisfaction With Information Provided By Physician Detailed Findings: Caregivers Base: Total Seeking Info on AFib Through Physician Directly (n=78) 9c. Overall, how satisfied were you with the information provided by (his/her) physician about (his/her) condition and increased risk of AFib-related stroke? Caregivers are generally satisfied with information provided by physicians.  Nearly one in two caregivers who received information from physicians (47%) were very satisfied with the information.  Six in seven caregivers who received information from physicians (87%) were very or somewhat satisfied with the information.

www. russellresearch.com 97 Topics of Discussion Between Patient and Physician Regarding Atrial Fibrillation-Related Stroke Detailed Findings: Caregivers 10. Has (his/her) physician ever discussed with (him/her) any of the following regarding AFib-related stroke? Risks associated with and without treatment is the most common topic of conversation between caregivers and physicians.  Seven in ten caregivers who have discussed AFib-related stroke with the survivor’s doctor (71%) talked about the risk of having AFib-related stroke with and without medication.  One in two caregivers who have discussed AFib-related stroke with the survivor’s doctor (51%) talked about the symptoms of AFib-related stroke.  Nearly one in two caregivers who have discussed AFib-related stroke with the survivor’s doctor (47%) talked about actions to take if witnessing or experiencing symptoms of AFib-related stroke.  Nearly one in two caregivers who have discussed AFib-related stroke with the survivor’s doctor (47%) talked about the impact of AFib-related stroke on everyday life. Base: Total Discussed Atrial Fibrillation-Related Stroke With Doctor (n=154)

www. russellresearch.com 98 Caregivers believe reduced risk and minimizing side effects are patients’ top priorities in treatment.  The most important Atrial Fibrillation treatment qualities to patients are that a treatment reduces the risk of a stroke caused by a blood clot in the brain (26%) and causes the least side effects (25%).  Being affordable is of lesser importance to patients, with only one-fifth of caregivers (20%) indicating it was the patient’s first or second most important treatment quality. Patient’s Most Important Qualities In Treatment Designed To Reduce Risk Of Stroke From Atrial Fibrillation Detailed Findings: Caregivers 11a. When discussing treatment options to reduce the risk of a stroke in atrial fibrillation with (his/her) doctor, which of the following is most important to (him/her)? 11b. And when discussing treatment options to reduce the risk of stroke in atrial fibrillation with (his/her) doctor, which of the following is second most important to (him/her)? Base: Total Discussed Increased Stroke Risk With Doctor (n=125)

www. russellresearch.com 99 While equally important to patients, caregivers first and foremost place importance on reducing the risk of stroke.  Nearly one-half of caregivers who have discussed treatment options with the patient’s physician (46%) indicate the most important quality in treatment is reducing the risk of a stroke caused by a blood clot in the brain, and seven in ten (69%) place it within the top two most important qualities.  One in six caregivers who have discussed treatment options with the patient’s physician (17%) indicate the most important quality in treatment is using a treatment which causes the least side effects, and nearly one-half (46%) place it within the top two most important qualities.  Being affordable is not of primary importance to caregivers, with only eight percent indicating it was their first or second most important treatment quality. Caregiver’s Most Important Qualities In Treatment Designed To Reduce Risk Of Stroke From Atrial Fibrillation Detailed Findings: Caregivers 14a. When you are discussing treatment options to reduce the risk of stroke in atrial fibrillation with (his/her) doctor, which of the following is most important to you? 14b. And when you are discussing treatment options to reduce the risk of stroke in atrial fibrillation with (his/her) doctor, which of the following is second most important to you? Base: Total Discussed Atrial Fibrillation-Related Stroke With Doctor (n=154)

www. russellresearch.com 100 Whether Patient Ever Taken Medications And Types Prescribed To Reduce Risk Of Atrial Fibrillation-Related Stroke Detailed Findings: Caregivers 12a. Has (his/her) physician ever had (him/her) take medications to reduce the risk of AFib-related stroke? 12b. To the best of your knowledge, what type(s) of treatment options has (his/her) physician prescribed (him/her) in order to reduce the risk of AFib-related stroke? Most caregivers indicate the person in their care has taken medication to reduce risk of AFib-related stroke.  More than nine in ten caregivers who have discussed Atrial Fibrillation- related stroke with a physician (92%) indicate that the physician has had the person in their care take medication to reduce their risk of AFib-related stroke.  Three in four caregivers who indicate the person in their care has taken medication to reduce their risk of AFib-related stroke (75%) indicate the survivor had been prescribed an oral anticoagulant.  Nearly two in five caregivers who indicate the person in their care has taken medication to reduce their risk of AFib-related stroke (38%) indicate the survivor had been prescribed an antiplatelet. Base: Total Have Taken Medication (n=142) Base: Total Discussed Atrial Fibrillation- Related Stroke With Doctor (n=154)

www. russellresearch.com 101 Whether Patient Regularly Takes Prescribed Treatment Detailed Findings: Caregivers Base: Total Have Taken Medication (n=142) 12c. To the best of your knowledge, does (he/she) regularly take the treatment to reduce the risk of AFib-related stroke prescribed by (his/her) doctor? Caregivers predominantly indicate those in their care are compliant with the prescribed treatment.  Nine in ten caregivers of survivors who have been prescribed mediation (89%) indicate the patient regularly takes their prescribed treatment to reduce their risk of AFib-related stroke.  Seven percent of caregivers of survivors who have been prescribed mediation indicate the patient stopped taking their prescribed treatment to reduce their risk of AFib-related stroke.

www. russellresearch.com 102 Topics of Discussion Between Caregiver and Physician Regarding Atrial Fibrillation-Related Stroke Detailed Findings: Caregivers 13. Has (his/her) physician ever discussed with you directly any of the following regarding stroke? A majority of caregivers who’ve discussed AFib with a physician covered the symptoms, impact, and actions to take.  Three in five caregivers who have discussed increased stroke risk with the patient’s physician (60%) have discussed the impact of AFib-related stroke on everyday life.  Three in five caregivers who have discussed increased stroke risk with the patient’s physician (59%) have discussed the symptoms of AFib-related stroke.  Nearly three in five caregivers who have discussed increased stroke risk with the patient’s physician (58%) have discussed the actions to take if witnessing symptoms of AFib-related stroke. Base: Total Discussed Increased Stroke Risk With Doctor (n=125)

www. russellresearch.com 103 Gender Believe Has Higher Risk Of Atrial Fibrillation-Related Stroke & Whether Able To Describe Most Common Symptoms Detailed Findings: Caregivers Base: Total Respondents (n=203) 15a. Who do you think has a higher risk of experiencing an AFib-related stroke? 15b. If asked, do you believe that you would be able to describe to someone the most common symptoms of a stroke? Caregivers almost universally believe they can detect the most common stroke symptoms.  More than nine in ten caregivers (92%) feel they are able to describe the common symptoms of stroke. Few caregivers know that women at are at higher risk of Atrial Fibrillation-related stroke.  Three in ten caregivers (30%) believe women have a higher risk of experiencing an AFib-related stroke.  One in four caregivers (25%) believe men have a higher risk of experiencing an AFib-related stroke.  Nearly one-half of caregivers (46%) do not believe either gender has a higher risk of experiencing an AFib-related stroke.

www. russellresearch.com 104 Symptoms Of Stroke Detailed Findings: Caregivers 16a. To the best of your knowledge, which, if any, of the following are symptoms of someone experiencing a stroke? Speaking and loss of movement are the most widely thought symptoms of stroke.  Virtually all caregivers (95%) believe sudden trouble speaking is a symptom of someone experiencing a stroke.  More than nine in ten caregivers (92%) believe sudden numbness/ tingling/weakness/loss of movement in face/arm/leg, especially on one side of the body is a symptom of someone experiencing a stroke.  Nearly nine in ten caregivers (88%) believe sudden problems with walking or balance is a symptom of someone experiencing a stroke.  Nearly nine in ten caregivers (88%) believe sudden confusion or trouble understanding simple statements is a symptom of someone experiencing a stroke.  More than three in four caregivers (77%) believe sudden vision changes is a symptom of someone experiencing a stroke. Base: Total Respondents (n=203)

www. russellresearch.com 105 Potential Outcomes After Having A Stroke Detailed Findings: Caregivers 16b. To the best of your knowledge, which, if any, of the following are possible outcomes after a stroke? Most caregivers believe there are a wide range of negative outcomes after experiencing a stroke.  More than nine in ten caregivers believe paralysis (93%), an inability to speak (92%), memory loss (92%), and balance issues (92%) are possible outcomes after having a stroke.  Nine in ten caregivers (90%) believe death is a possible outcome after having a stroke.  Nearly nine in ten caregivers believe recurrent stroke (88%), weakness (88%), inability to drive (87%), and weakness (86%) are possible outcomes after having a stroke. Base: Total Respondents (n=203)

www. russellresearch.com 106 Aid Would Find Helpful In Providing Care To Patient Detailed Findings: Caregivers 16c. Which of the following would you find useful in helping provide care? Physical, tangible, and financial aid would all be viewed as helpful to caregivers.  Seven out of ten caregivers (70%) would find physical help useful in helping provide care.  More than three in five caregivers would find home modifications (63%), financial assistance (63%) and respite care (62%) useful in helping provide care. Base: Total Respondents (n=203)

www. russellresearch.com 107 Patient Atrial Fibrillation Statement Agreement Detailed Findings: Caregivers 17. Thinking about the person who you care for, how much do you think (he/she) would have agreed or disagreed with each of the following statements prior to experiencing a stroke? Caregivers widely believe that prior to experiencing a stroke, the person in their care would have adhered to treatment and physician visits, regardless of cost. However, less agree that they learned all they could have about their condition.  Nine in ten caregivers (89%) believe the survivor in their care would agree that it would not matter if the treatment to reduce the risk of AFib-related stroke had to be taken once or twice a day.  Five in six caregivers (84%) believe the survivor in their care would agree that if a treatment that reduced risk of AFib-related stroke required regular visits to their physician, they would have done it.  One-half of caregivers (49%) feel their patient in their care would agree that they sought to find out everything they could about Atrial Fibrillation and AFib-related stroke risk. Base: Total Respondents (n=203)

www. russellresearch.com 108 Caregiver Atrial Fibrillation Statement Agreement Detailed Findings: Caregivers 17b. How much do you personally agree or disagree with each of the following statements regarding (his/her) Atrial Fibrillation prior to experiencing an AFib-related stroke? Caregivers would have near universally encouraged and had their loved ones adhere to treatment that would reduce the risk of AFib-related stroke. There is also regret in not having more information.  Virtually all caregivers (97%) would have encouraged their patient to follow a treatment if it required regular visits to their physician.  Nearly all caregivers (96%) believe the person in their care should do what the physician tells them to do in order to reduce the risk of AFib-related stroke.  Nine in ten caregivers (89%) would have liked to have had more information about Atrial Fibrillation and learned more about AFib-related stroke. Base: Total Respondents (n=203)

www. russellresearch.com 109 Caregiver Atrial Fibrillation Fact Awareness Detailed Findings: Caregivers 18. I will now read you a list of facts about Atrial Fibrillation. Please tell me whether you were previously aware or not previously of these facts. There is little awareness of the impact of AFib-related strokes.  More than one in five caregivers (22%) are aware that AFib-related strokes are nearly twice as likely to be fatal or disabling as non-AFib-related strokes.  One in four caregivers (25%) are aware that women with Atrial Fibrillation have a higher risk of ischemic stroke than men.  Less than one-half of caregivers (44%) are aware that you can have 5 times greater risk for stroke if you are living with untreated Atrial Fibrillation. Base: Total Respondents (n=203)

www. russellresearch.com 110 Patient Stroke Statement Agreement Detailed Findings: Caregivers 19. Thinking about the person who you care for, how much do you think (he/she) would agree or disagree with each of the following statements? Caregivers believe the people in their care underestimated how bad experiencing a stroke could be to them.  Nearly nine in ten caregivers (88%) think the survivor in their care would agree that their life has not been the same since experiencing an AFib- related stroke.  Five in six caregivers (86%) believe the survivor in their care would agree that experiencing a stroke was worse than they had imagined.  Less than three in five caregivers (55%) believe the survivor in their care would agree that having a stroke was their biggest fear.  Three in four caregivers (74%) believe the survivor in their care would agree that there was not enough information on reducing the risk of AFib- related stroke provided to the caregiver when the survivor was initially diagnosed with Atrial Fibrillation. Base: Total Respondents (n=203)

www. russellresearch.com 111 Caregiver Stroke Statement Agreement Detailed Findings: Caregivers 19b. How much do you personally agree or disagree with each of the following statements? While caregivers universally try to make the lives better of the survivors they care for, it requires more work than they thought and most would like more support and information.  Virtually all caregivers (98%) agree that since their patient experienced an AFib-related stroke, they have tried to have them focus on improving their health.  Nine in ten caregivers (91%) agree that their lives have not been the same since the person in their care experienced an AFib-related stroke.  Six in seven caregivers (86%) couldn’t have imagined the amount of work it takes to care for a stroke survivor.  Five in six caregivers (83%) wish they had more support and information to take care of the survivor in their care.  Four in five caregivers (81%) wish they had more information on Atrial Fibrillation and Stroke. Base: Total Respondents (n=203)

www. russellresearch.com 112 Patient’s Life Changes Since Stroke Detailed Findings: Caregivers 20. You had earlier mentioned that (his/her) life has not been the same since experiencing an AFib-related stroke. In which, if any, of the following ways has (his/her) life changed? Caregivers see a physical and emotional toll taken on the lives of survivors.  Three in four caregivers (75%) indicate the survivor in their care can no longer drive and needs assistance with daily activities.  Nearly three in four caregivers (73%) indicate the survivor in their care feels like they are a burden on their family.  Two in three caregivers (65%) indicate the survivor in their care feels isolated. Base: Total Agree Patient’s Life Has Changed (n=179)

www. russellresearch.com 113 Ways Caregiver’s Life Has Changed Since Patient’s Stroke Detailed Findings: Caregivers 20b. In which, if any, of the following ways has your life changed since becoming a caregiver to a stroke survivor? A majority of caregivers feel overwhelmed and have less time for themselves, and many have a different relationship with the survivor.  More than nine in ten caregivers (92%) feel they have a lot more responsibilities since becoming a caregiver.  Two in three caregivers (66%) don’t have as much time to do activities or hobbies that bring them joy.  Three in five caregivers (60%) feel like they have more to do than they can handle.  Nearly three in five caregivers (56%) feel more socially isolated.  More than two in three caregivers (68%) feel their relationship is different with their patient since they suffered a stroke. Base: Total Respondents (n=203)

www. russellresearch.com 114 Detailed Findings: Caregivers Total Total Respondents(203) % Caregiver Gender Male16 Female84 Mean Age58.6 Patient Gender Male57 Female43 Relationship To Patient Your spouse44 A family member44 A friend4 Paid caregiver4 Devices Own Desktop computer66 Laptop or netbook computer81 Mobile/cell phone86 iPad or other tablet56 E-reader29 Devices Use To Access Health Information Desktop computer52 Laptop or netbook computer61 Mobile/cell phone29 iPad or other tablet38 E-reader4 None of the above1 Caregiver Demographic Profile Total Total Respondents(203) % Marital Status Married75 Not Married (net)24 Education No College (net)12 College (net)87 Employment Status Employed (net)38 Not Employed (net)61 Median Household Income$60.7 Ethnic Background African-American4 Asian/Pacific Islander3 Caucasian88 Hispanic/Latino2 Mixed ethnic background1 Type Of Community Urban17 Suburban55 Rural28 Census Region Northeast25 South33 Midwest26 West17

AF Survey Final Report AUGUST 2014 Prepared by:. www. russellresearch.com 1 Study Overview The purpose of this study was to evaluate the impact of Atrial.

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AF Survey Final Report AUGUST 2014 Prepared by:. www. russellresearch.com 1 Study Overview The purpose of this study was to evaluate the impact of Atrial.

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Presentation on theme: "AF Survey Final Report AUGUST 2014 Prepared by:. www. russellresearch.com 1 Study Overview The purpose of this study was to evaluate the impact of Atrial."— Presentation transcript:

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