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Infrafrontier The European infrastructure for phenotyping and archiving of model mammalian genomes Coordinator: Prof. Martin Hrabé de Angelis Project Office:

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Presentation on theme: "Infrafrontier The European infrastructure for phenotyping and archiving of model mammalian genomes Coordinator: Prof. Martin Hrabé de Angelis Project Office:"— Presentation transcript:

1 Infrafrontier The European infrastructure for phenotyping and archiving of model mammalian genomes Coordinator: Prof. Martin Hrabé de Angelis Project Office: Dr. Michael Raess, Dr. Ana de Castro Helmholtz Zentrum München

2 European Strategy Forum on Research Infrastructures

3 ESFRI roadmap BBMRI – biobanking EATRIS – translational research ECRIN – clinical trials ELIXIR – bioinformatics Infrafrontier – animal disease models INSTRUCT – structural biology EU-OPENSCREEN – chemical biology BLS4 – high security labs Euro-BioImaging - bioimaging EMBRC – marine biology Firstroadmap in 2006 Firstroadmap in 2006 Firstroadmap in projects Update in Dec2008 Update in Dec2008 Update in Dec projects

4 Grand Challenges - Understand genetic and environmental impact on human health - Develop novel strategies for diagnosis, prevention and therapies

5 Current Biology Why mouse? Mouse genome fully sequenced 95% similarity of the genes of mice and men Easy to breed and handle in captivity Extensive toolbox for manipulating the mouse genome

6 Why mouse? Mouse models achieve high impact Publications on Mouse Models

7 Shortage on capacities and access: Phenotyping (characterising mouse models) Mouse Clinics EUMODIC, Infrafrontier Archiving and Dissemination of mice and data Repositories EMMA, Infrafrontier The challenge

8 Required capacities Archiving and distribution Phenotyping 1500 p.a. 420 p.a p.a. 350 p.a.

9 Access to phenotyping data and mouse models Infrafrontier Phenomefrontier Archivefrontier + emerging centres Infrafrontier: two main parts Systemic Phenotyping Archivefrontier/EMMA Archiving / Distribution Access to phenotyping services, data and mouse models

10 Capacity building required!

11 Osteogenesis imperfecta A group of genetic bone disorders... Noted People with OI Jazz pianist Michel Petrucciani Actor writer and ethicist Peter Radke... In the mouse model: Bisphosphonate treatment … reverses bone phenotype … but does not lower mortality

12 The German Mouse Clinic Nature Methods 2005, Nature Genetics 2005, Nature Genetics 2008, Cell 2009

13 - Mutation in collagen I Bone phenotype Mineralisation defect Bone deformity fractures Beaded ribs Reduced Bone mineral content & decreased bone mineral density Systemic Lung phenotype Heart phenotype Reduced fat mass & increased lean mass Metabolic alterations Mouse model for Osteogenesis imperfecta

14 12 European Countries + Canada Research Institutions + Funding Agencies Infrafrontier partners

15 Infrafrontier partners

16 Infrastructure Large Project Smaller Project

17 Very large Project: International Mouse Phenotyping Consortium (IMPC)

18 Infrafrontier and IMPC Keep in mind: Infrafrontier is a BMS research infrastructure, NOT a single project Infrafrontier has a different and broader portfolio than IMPC (infrastructure for bottom-up and top-down projects) State of the art research infrastructures are highly dynamic entities

19 Official start:01 March months until: 28 February Mio funding by the European Commission Infrafrontier preparatory phase

20 Infrafrontier implementation

21 Infrafrontier implementation

22 Access to mouse resources and data

23 Operation Costs Cohort Breeding 23,000 – 30,000 per line Cohort Breeding 23,000 – 30,000 per line Phenotyping 15,000 – 20,000 per line Phenotyping 15,000 – 20,000 per line Mouse Archiving 3,500 – 4,400 per line Mouse Archiving 3,500 – 4,400 per line Mouse Distribution 1,100 – 2,100 per line Mouse Distribution 1,100 – 2,100 per line ES Cell Distribution ? per line ES Cell Distribution ? per line User Fees 1,100 – 1,700 User Fees 1,100 – 1,700 User Fees 500 –700 User Fees 500 –700 User Fees to be developed User Fees to be developed

24 New mouse clinics and EMMA nodes Established facilities New facilities

25 Physical Infrastructure Personnel Operation Technology Development Integration of national & European funds National infrastructure funds National and European Projects Funding Strategy

26 MS European Commission Central Coordination MS MS = Member State Decentralised funding model

27 Governance Infrafrontier ERIC (Boards)

28 Governance Infrafrontier ERIC (Tasks)

29 More Information ….

30 Resource Sharing Policy The Rome Agenda: Funding organizations should … cover the costs of deposition of materials arising from projects as part of the project budget. Funding agencies should … ensure appropriate data- sharing plans at the outset of projects …

31 More Information …. Coordinator: Prof. Dr. Martin Hrabé de Angelis Project Office: Dr. Michael Raess Dr. Ana de Castro Helmholtz Zentrum München Institute of Experimental Genetics Ingolstädter Landstrasse Neuherberg

32 Infrafrontier The European infrastructure for phenotyping and archiving of model mammalian genomes Coordinator: Prof. Martin Hrabé de Angelis Project Office: Dr. Michael Raess, Dr. Ana de Castro Helmholtz Zentrum München

33 Scope of Activities

34 Constructing Required Capacities Mouse Clinics Initial Investment (100 mouse lines): ~ 15,000,000 for Construction ~ 5,000,000 for Equipment Adding capacities for 100 lines ~ 6,500,000 Mouse Clinics Initial Investment (100 mouse lines): ~ 15,000,000 for Construction ~ 5,000,000 for Equipment Adding capacities for 100 lines ~ 6,500,000 EMMA Repository Initial Investment (100 mouse lines): ~ 6,600,000 for Construction ~ 2,000,000 for Equipment Adding capacities for 100 lines ~ 1,300,000 EMMA Repository Initial Investment (100 mouse lines): ~ 6,600,000 for Construction ~ 2,000,000 for Equipment Adding capacities for 100 lines ~ 1,300,000

35 Maintaining Capacities Mouse Clinics Maintaining and Updating Equipment ~ 20% of Purchasing Price per year Mouse Clinics Maintaining and Updating Equipment ~ 20% of Purchasing Price per year EMMA Repository Cryo-Archive (100 mouse lines): ~ 10,000 per year Maintaining and Updating Equipment ~ 10% of Purchasing Price per year EMMA Repository Cryo-Archive (100 mouse lines): ~ 10,000 per year Maintaining and Updating Equipment ~ 10% of Purchasing Price per year

36 Infrafrontier project – key objectives Preparation to meet increasing demands for phenotyping and archiving – capacity building Developing a business plan based on a sustainable funding concept Identification of the most suitable legal form Providing a strategic plan for the construction phase Reaching a legal agreement between all partners

37 Implementation Preparatory Phase Key deliverables WP2 – Strategy and Governance WP3 – Legal Work WP4 – Financial Work & Funding WP2 WP3 Legal Work MoU Strategic Plan Draft Strategic Plan WP4 Finance Business Plan Legal status Update


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