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Mammalian Liver tissue: X.

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Presentation on theme: "Mammalian Liver tissue: X."— Presentation transcript:

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8 Mammalian Liver tissue: X

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16 (note: no ATP required!)

17 Glycogenin: catalyzes glucose transfer from UDP-glucose (red) to tyr 194 (blue); Mn 2+ (green) required to stabilize UDP leaving group

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19 Rabbit muscle Phosphorylase Kinase γ (catalytic) subunit active fragment complexed with ATP and a heptapeptide (RQMSFRL).

20 Phosphorylase kinase δ subunit (calmodulin)

21 As with glycogen phosphorylase: (a) phosphorylase kinase found in two isoforms in both muscle/liver tissues either active or inactive for glycogen breakdown (b) these isoforms differed by phosphorylation

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23 Catalytic (C) subunit of mouse protein kinase A (PKA) complexed with ATP and a peptide inhibitor (Ser→Ala)

24 Regulatory (R) subunit of bovine protein kinase A (PKA) complexed with 2 cyclic-AMP molecules (activate C*R dissociation)

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