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Pre-Tx 18 F-FDOPA PET Pre-Tx T1+C Post-Tx 18 F-FDOPA PET Difference Post-Pre Tx 18 F-FDOPA PET IOIS: 3401 Benjamin M. Ellingson, Ph.D., Dept. of Radiological.

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Presentation on theme: "Pre-Tx 18 F-FDOPA PET Pre-Tx T1+C Post-Tx 18 F-FDOPA PET Difference Post-Pre Tx 18 F-FDOPA PET IOIS: 3401 Benjamin M. Ellingson, Ph.D., Dept. of Radiological."— Presentation transcript:

1 Pre-Tx 18 F-FDOPA PET Pre-Tx T1+C Post-Tx 18 F-FDOPA PET Difference Post-Pre Tx 18 F-FDOPA PET IOIS: 3401 Benjamin M. Ellingson, Ph.D., Dept. of Radiological Sciences, David Geffen School of Medicine at UCLA, 2011 POSITRON EMISSION TOMOGRAPHY PARAMETRIC RESPONSE MAP (PET-PRM) RESPONDERChange in 18 F-FDOPA Signal + Increase - Decrease

2 Pre-Tx T1+C Difference Post-Pre Tx 18 F-FDOPA PET IOIS: 3401 Benjamin M. Ellingson, Ph.D., Dept. of Radiological Sciences, David Geffen School of Medicine at UCLA, 2011 POSITRON EMISSION TOMOGRAPHY PARAMETRIC RESPONSE MAP (PET-PRM) Change in 18 F-FDOPA Signal + Increase - Decrease

3 Pre-Tx 18 F-FDOPA PET Pre-Tx T1+C Post-Tx 18 F-FDOPA PET Difference Post-Pre Tx 18 F-FDOPA PET IOIS: 2383 Benjamin M. Ellingson, Ph.D., Dept. of Radiological Sciences, David Geffen School of Medicine at UCLA, 2011 POSITRON EMISSION TOMOGRAPHY PARAMETRIC RESPONSE MAP (PET-PRM) NON-RESPONDERChange in 18 F-FDOPA Signal + Increase - Decrease

4 Pre-Tx T1+C Difference Post-Pre Tx 18 F-FDOPA PET IOIS: 2383 Benjamin M. Ellingson, Ph.D., Dept. of Radiological Sciences, David Geffen School of Medicine at UCLA, 2011 POSITRON EMISSION TOMOGRAPHY PARAMETRIC RESPONSE MAP (PET-PRM) NON-RESPONDERChange in 18 F-FDOPA Signal + Increase - Decrease

5 Benjamin M. Ellingson, Ph.D., Dept. of Radiological Sciences, David Geffen School of Medicine at UCLA, 2011 POSITRON EMISSION TOMOGRAPHY PARAMETRIC RESPONSE MAP (PET-PRM) NON-RESPONDER Change in 18 F-FDOPA Signal + Increase - Decrease RESPONDER Pre-Tx DOPA Tumor Volume = 117.5 mL DOPA PRM % Decreasing DOPA Uptake = 93.0% % Increasing DOPA Uptake = 7.0 % Pre-Tx DOPA Tumor Volume = 18.3 mL DOPA PRM % Decreasing DOPA Uptake 72.8% % Increasing DOPA Uptake = 27.2 %

6 Benjamin M. Ellingson, Ph.D., Dept. of Radiological Sciences, David Geffen School of Medicine at UCLA, 2011 POSITRON EMISSION TOMOGRAPHY PARAMETRIC RESPONSE MAP (PET-PRM) % Change in 18 F-FDOPA Signal + 100% - 100% RESPONDER > 50% Change % Decreasing DOPA Uptake = 93.0% % Decreasing > 25% change = 47.9% % Decreasing > 50% change = 18.2% % Increasing DOPA Uptake = 7.0 % % Increasing > 25% change = 0.9% % Increasing > 50% change = 0.0% > 25% Change All Changes

7 Benjamin M. Ellingson, Ph.D., Dept. of Radiological Sciences, David Geffen School of Medicine at UCLA, 2011 POSITRON EMISSION TOMOGRAPHY PARAMETRIC RESPONSE MAP (PET-PRM) % Change in 18 F-FDOPA Signal + 100% - 100% NON-RESPONDER > 50% Change % Decreasing DOPA Uptake = 72.8% % Decreasing > 25% change = 31.9% % Decreasing > 50% change = 2.7% % Increasing DOPA Uptake = 27.2 % % Increasing > 25% change = 3.2% % Increasing > 50% change = 0.05% > 25% Change All Changes

8 Benjamin M. Ellingson, Ph.D., Dept. of Radiological Sciences, David Geffen School of Medicine at UCLA, 2011 POSITRON EMISSION TOMOGRAPHY PARAMETRIC RESPONSE MAP (PET-PRM) % Decreasing DOPA% Increasing DOPA

9 Benjamin M. Ellingson, Ph.D., Dept. of Radiological Sciences, David Geffen School of Medicine at UCLA, 2011 POSITRON EMISSION TOMOGRAPHY PARAMETRIC RESPONSE MAP (PET-PRM) NON-RESPONDER Change in 18 F-FDOPA Signal + Increase - Decrease RESPONDER VOLUME OF DECREASING DOPA UPTAKE = 7.4 mL VOLUME OF INCREASING DOPA UPTAKE = 1.2 mL VOLUME OF DECREASING DOPA UPTAKE = 175.5 mL VOLUME OF INCREASING DOPA UPTAKE = 0.8 mL

10 XXXX 18 F-FDOPA PET Parametric Response Maps (PET PRMs) Change in PET Signal -5000+ 5000 Baseline: 3/10/09 Benjamin M. Ellingson, Ph.D., Dept. of Radiological Sciences, David Geffen School of Medicine at UCLA, 2011 10/20/09 3/30/10 10/12/10 2/15/11

11 XXXX 18 F-FDOPA PET Parametric Response Maps (PET PRMs) Baseline: 3/10/09 Benjamin M. Ellingson, Ph.D., Dept. of Radiological Sciences, David Geffen School of Medicine at UCLA, 2011

12 Pre-Tx 18 F-FDOPA PET Pre-Tx T1+C Pre-Tx 18 F-FLT PET Combined 18 F-FLT and 18 F-FDOPA FLTDOPAFLT+DOPA IOIS: 3401 Benjamin M. Ellingson, Ph.D., Dept. of Radiological Sciences, David Geffen School of Medicine at UCLA, 2011 MALIGNANT MARKER MAPS ( 18 F-FLT and 18 F-FDOPA )

13 Benjamin M. Ellingson, Ph.D., Dept. of Radiological Sciences, David Geffen School of Medicine at UCLA, 2011 MALIGNANT MARKER MAPS ( 18 F-FDOPA + CBV + ADC )

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