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APh161 - Lecture 2: The Rate of Things Rob Phillips California Institute of Technology (Pollard and Earnshaw)

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Presentation on theme: "APh161 - Lecture 2: The Rate of Things Rob Phillips California Institute of Technology (Pollard and Earnshaw)"— Presentation transcript:

1 APh161 - Lecture 2: The Rate of Things Rob Phillips California Institute of Technology (Pollard and Earnshaw)

2 The Hierarchy of Time Scales

3 E. Coli Cell Division: The Standard Stopwatch

4 E. Coli Cell Division: The Bacterial Growth Curve http://www-micro.msb.le.ac.uk/LabWork/bact/-4L.jpg Other ways of counting cells 0.009/min

5 The Eukaryotic Cell Cycle Pollard and Earnshaw Adapted from Murray and Hunt

6 Cell Division Movies See CD accompanying Essential Cell Biology. There are beautiful movies of cell division.

7 The Processes of the Central Dogma

8 Timing of Gene Expression: How Cells Decide What to Eat Monod thesis

9 Timing of Gene Expression Lucy Shapiro et al., Stanford

10 Putting the Stopwatch on Cell Division and Cell Motility http://cmgm.stanford.edu/theriot/movies.htmhttp://cmgm.stanford.edu/theriot/movies.htm - the place to be! These movies allow for an estimate of the rate of actin polymerization. Show movies of cell division - problem often with the movies is no timer showing how long the video lasts in real time units. The concept is to estimate the rate of microtubule polymerization.

11 A reminder on the cytoskeleton

12 Embryonic Development: Telescoping up in Time


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