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Life History Traits and Genome Structure Aerobiosis and G+C Content in Bacteria J.R. Lobry Université Claude Bernard - Lyon I CNRS UMR 5558 & INRIA Helix.

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Presentation on theme: "Life History Traits and Genome Structure Aerobiosis and G+C Content in Bacteria J.R. Lobry Université Claude Bernard - Lyon I CNRS UMR 5558 & INRIA Helix."— Presentation transcript:

1 Life History Traits and Genome Structure Aerobiosis and G+C Content in Bacteria J.R. Lobry Université Claude Bernard - Lyon I CNRS UMR 5558 & INRIA Helix FRANCE

2

3 Aerobic versus Anaerobic You need the presence of O 2 to live, you are aerobic (obligate) You need the absence of O 2 to live, you are anaerobic (obligate) [...snip...]

4 Only Anaerobic Species Anaerobic and Aerobic Species

5 Aerobic >> Anaerobic In aerobic conditions (with O 2 ) the oxydation of one molecule of glucose (respiration) yields 38 ATP (metabolic currency unit). Short generation times. In anaerobic conditions (without O 2 ) the fermentation of one molecule of glucose yields 2 ATP (metabolic currency unit). Long generation times. The generation time is a life history trait

6 Life History Traits and Genome Structure Aerobiosis and G+C Content in Bacteria J.R. Lobry Université Claude Bernard - Lyon I CNRS UMR 5558 & INRIA Helix FRANCE

7 Bacteria in the Universal Tree of Life Pseudomonas Escherichia Halobacterium Methanobacterium Desulfurococcus Halococcus Methanococcus Thermoproteus Thermus Anacystis Bacillus Physarum Crithidia Tetrahymena Prorocentrum SaccharomycesOryza Homo Drosophila Streptomyces EUCARYA ARCHAEA EUBACTERIA « BACTERIA » ?

8 Only Bacteria Bacteria and Eucarya

9 Bacterial Genomes: Circular dsDNA Here G+C = 50% The G+C content is a genome structure

10 Life History Traits and Genome Structure Aerobiosis and G+C Content in Bacteria J.R. Lobry Université Claude Bernard - Lyon I CNRS UMR 5558 & INRIA Helix FRANCE

11 Aerobiosis and G+C Content in Bacteria AerobicAnaerobic Naya et al. (2002) J. Mol. Evol., 55:260

12 Aerobiosis and G+C Content in Bacteria AerobicAnaerobic Naya et al. (2002) J. Mol. Evol., 55:260 Why?

13 Metabolic cost of amino-acids in Aerobiosis Akashi & Gojobori (2002) PNAS, 99: ATP 38.3 ATP 11.7 ATP 52.0 ATP 15.3 ATP 14.7 ATP 27.3 ATP

14 From amino-acid cost to Protein cost Akashi & Gojobori (2002) PNAS, 99:3695 Protein cost in ATP Protein concentration in cells

15 So what?

16 The growth of genomic data But available fossil DNA is < years...

17 All data are here

18 Dataset ~300 bacterial species ~1,000,000 proteins ~100,000,000 amino-acids

19 Akashi (2002) Naya (2002)

20 Interpretation Aerobic bacteria have a higher genomic G+C content than anerobic bacteria because this induces an average protein composition which is less expensive in aerobic conditions

21 Aerobiosis and G+C Content in Bacteria Life History Traits and Genome Structure J.R. Lobry Université Claude Bernard - Lyon I CNRS UMR 5558 & INRIA Helix FRANCE


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