1. By Ryan Johnson

2. General Overview  NTD  >20% of human population infected  Locally underestimated  Public health crucial

3. Trichuris Nematodes Coevolved with Man  Infects old and new world monkeys  Discovered in 1740

4. Morphology

5. Fecal-Oral Transmission  Soil to mouth

7. Embryonic Development Must Occur Outside of the Human 3 weeks later I won’t be able to hatch in your stomach if you eat me now. Gimme 3 weeks! Time’s up… …EAT ME!!!

9. Signs and Symptoms  Light infestation – asymptomatic  Severe infestation – GI problems

10. Treatment  Mebendazole

11. Prevents Microtubule Polymerization

14. Preventive Chemotherapy  Heaviest burden on kids  Treatment 2x a year  1 dose = fraction USD

19.  http://en.wikipedia.org/wiki/Trichuriasis http://en.wikipedia.org/wiki/Trichuriasis  Fernando, Ranjan L; Tropical infectious diseases : epidemiology, investigation, diagnosis and management; London : Greenwich Medical Media, 2004.  http://www.who.int/intestinal_worms/en/index.html http://www.who.int/intestinal_worms/en/index.html  Hutchinson, et al; Clinical Trial of Mebendazole, A Broad-spectrum Anthelminthic; http://www.ncbi.nlm.nih.gov/pmc/articles/PMC168191 8/pdf/brmedj01446-0019.pdf/?tool=pmcentrez http://www.ncbi.nlm.nih.gov/pmc/articles/PMC168191 8/pdf/brmedj01446-0019.pdf/?tool=pmcentrez  Miller, et al; Mebendazole, An Effective Anthelmintic for Trichuriasis and Enterobiasis; http://jama.ama- assn.org/cgi/reprint/230/10/1412.pdf