We think you have liked this presentation. If you wish to download it, please recommend it to your friends in any social system. Share buttons are a little bit lower. Thank you!
Presentation is loading. Please wait.
Published bySofia Harper
Modified over 3 years ago
Overwhelming fungal infection in a Toll deficient background
Comparison of structures of CD14, Toll and IL-1RTIR domain Leucine rich domains NF-kB Leucine rich domains Ig-like domains CD14 IL-1R GPI anchor Cell membrane TIR domain NF-kB
Nature, Vol 388, 24 july 1997,
Toll-like receptors 1 2 3 4 5 6 7 8 9 10 ssRNA IMQ CpG IMQ dsRNAFlagellin LPS LP PG, LP Zym, LP 1 2 3 4 5 6 7 8 9 10
Modèle proposé Complexe ternaire : 1 homodimères + ARNdbPermet le chevauchement des TIR engageant la signalisation.
Parallels between IL-1 and Spz functionsMicrobial inducers ProSpz Spaetzle Drosophila NF-kB Drosomycin IL-1 NF-kB TLR PGRP-SA GNBP-1 Toll Mammals NF-kB IL-1R Defensin IL-1
hKIR TREM Ig-SF NCR m PIR h LIR (ILT) NKRP-1 mLY49 NKG2D C-type Lectins Mannose Rec. (MR, Endo180, DEC205, PLA2R) DC-SIGN receptors Dectin-2 (NCCL) Langerin BDCA-2 (DLEC) TLR Others (LRR, CARD,…) NOD molecules TLR
Toll-like receptors Bridging the innate and adaptive immune responses June 1, 2005 MIMG 261 Stephan Krutzik, Ph.D.
TNF superfamily TNF: produced by macrophages, monocytes, lymphocytes, fibroblasts upon inflammation, infection, injury, environmental challenges.
Toll-Like Receptors (TLR). Toll-Like Receptor Signaling Toll receptor initially discovered in Drosophila as important receptor in dorso-ventral embryonic.
RECOGNITION BY SOLUBLE MOLECULES MANNOSE BINDING LECTIN.
EPITHELIAL CELLS Pattern recognition receptors (PRR) Cytokine, chemokine secretion NEUTROPHIL GRANULOCYTES Phagocytósis Intracellular cytotoxicity MONOCITE.
Toll-like receptors: recent advances, open questions and implications for aspergillosis control. Frank Ebel Max-von-Pettenkofer-Institut, Munich, Germany.
Sinuses Trachea Lungs AIRWAY SYSTEM EYE Oral cavity Esophagus Stomach Alimentary tract GASTROINTESTINAL SYSTEM Demage Infection Mucus glycoproteins, proteoglycanes,
Manifestation of Novel Social Challenges of the European Union in the Teaching Material of Medical Biotechnology Master’s Programmes at the University.
3RD SEMINAR INNATE IMMUNITY: ANTIVIRAL STATE, KILLER CELLS, THE COMPLEMENT SYSTEM.
TOLL-LIKE RECEPTORS. Toll-like receptors & Host-Pathogen Interaction O’Neill, Luke A.J. “Immunity’s Early-Warning System”. Scientific American, Jan (2005),
RECOGNITION BY THE INNATE IMMUNE SYSTEM. FUNCTIONAL ATTRIBUTES OF INNATE AND ADAPTIVE IMMUNITY.
Response of the Innate Immune System to Pathogens: Pattern Recognition Receptors.
An integrated model of the recognition of Candida albicans by the innate immune system Nature Reviews / Microbiology Volume 6 / January 2008 Lab of Biochemistry,
INNATE IMMUNİTY. If any invader penetrate the body’s first line defense mechanisms: The second line or the first line immunologic defense Innate immunity.
Protein Protein Interactions: The Inflammasome Mark D. Wewers, M.D. Davis Heart and Lung Research Institute.
1 Innate immunity Abul K. Abbas University of California San Francisco FOCiS.
The TLR5 1174C>T Polymorphism in Melioidosis Infection Chief of Medicine Conference 10/2/12 Presented by Amy Dickey, MD R2, Internal Medicine Principal.
Innate Immunity1 Self-Test Questions: A: both B1: all B2-3: 1 - 6, 9 B4: B5: B6: 1 Review on your own: Clathrin-mediated endocytosis Endomembrane.
Innate vs. Adaptive Immunity Primitive (found in all multicellular organisms) Directed towards types of molecules Effectors are broadly reactive Response.
Novel signaling paradigm regulating TOLL- like receptors in innate immune cells Samar Abdulkhalek and Myron R. Szewczuk*. Dept. Biomedical and Molecular.
Antigen recognition in innate and adaptive immunity Diversity in antigen recognition receptors.
THE TWO „ARMS” OF THE IMMUNE SYSTEM INNATE/NATURAL IMMUNITY ACQUIRED IMMUNITY.
Biochemical Markers in the inflammatory response Dr Claire Bethune Consultant Immunologist Derriford Hospital.
TLR X-ray structures Harma Brondijk Bio-informatics course 2009.
TWO ARMS OF THE IMMUNE SYSTEM INNATE IMMUNITY ACQUIRED IMMUNITY.
Chapter 14: Innate Immune System. Overview of Immune Defenses First-line defenses: – Intact, healthy skin and mucous membranes – Normal microbiota.
Receptors of the innate immune system Nadine Sündermann.
Interferons Type I IFN IFN-ω IFN- IFN- IFN- IFN- IFN- IFN- Type II IFN IFN- Type III IFN IFN- IL B IFN- IL IFN- IL.
1Biol 466Toll-7 Project Determining the role of Toll-7 in Drosophila melanogaster through RNAi Biol466, Spring 2004 Cassandra Kleve.
Lecture 2 Innate immunity General features of innate immunity Example of an inducible innate immune mechanism interferon Example of a preformed innate.
Innate immunity Properties of innate immunity Recognition of microbes by innate immune system –structures that are recognized (“molecular patterns”) –receptors.
The Innate Immune Response to Bacterial and Fungal Infections.
Lecture on Innate Immunity and Inflammation Evolutionary View Epithelial barriers to infection Four main types of innate recognition molecules:TLRs, CLRs,
Topics Sensor systems Phagocytosis Inflammation Interferons Fever.
How is the Immune Response Initiated? What are the ligands and receptors? Infectious-Nonself Model –Charles Janeway Jr. –Cold Spring Harbor Symp. Quant.
1 Vol. 02. p Vol. 02. p Vol. 02. p.30.
1 Vol. 01. p Vol. 01. p Vol. 01. p.20.
1 Vol. 03. p Vol. 03. p Vol. 03. p.21.
1 Vol. 02. p Vol. 02. p Vol. 02. p.19.
1 Vol. 03. p Vol. 03. p Vol. 03. p.16.
1 Vol. 03. p Vol. 03. p Vol. 03. p.35.
1 Vol. 02. p Vol. 02. p Vol. 02. p.10.
1 Vol. 01. p Vol. 01. p Vol. 01. p.14.
LE MOMENT. Calcul des moments LE MOMENT Calcul des moments.
Chapter 2. Innate immunity. The response to an initial infection Figure Innate immunity - Early induced response - Adaptive immune response.
Molecular signalling in inflammation 2 lectures 2 nd Med Molecular Medicine Andrew Bowie, School of Biochemistry and Immunology.
Date of download: 7/8/2016 Copyright © 2016 McGraw-Hill Education. All rights reserved. Cellular signaling pathways for production of inflammatory cytokines.
© 2017 SlidePlayer.com Inc. All rights reserved.