1. Overwhelming fungal infection in a Toll deficient background

2. Comparison of structures of CD14, Toll and IL-1R
TIR
domain
Leucine rich domains
NF-kB
Leucine rich domains
Ig-like domains
CD14
IL-1R
GPI anchor
Cell
membrane
TIR
domain
NF-kB

3. Nature, Vol 388, 24 july 1997,

4. Bruce Beutler

5. Toll-like receptors 1 2 3 4 5 6 7 8 9 10 ssRNA IMQ CpG IMQ dsRNA
Flagellin
LPS LP
PG, LP
Zym, LP 1 2 3 4 5 6 7 8 9 10

7. Modèle proposé Complexe ternaire : 1 homodimères + ARNdb
Permet le chevauchement des TIR engageant la signalisation.

8. Parallels between IL-1 and Spz functions
Microbial
inducers
ProSpz
Spaetzle
Drosophila
NF-kB
Drosomycin
IL-1
NF-kB
TLR
PGRP-SA
GNBP-1
Toll
Mammals
NF-kB
IL-1R
Defensin
IL-1

9. Sang

10. hKIR
TREM
Ig-SF
NCR
m PIR
h LIR (ILT)
NKRP-1
mLY49
NKG2D
C-type
Lectins
Mannose Rec. (MR, Endo180, DEC205, PLA2R)
DC-SIGN receptors
Dectin-2 (NCCL)
Langerin
BDCA-2 (DLEC)
TLR
Others
(LRR, CARD,…)
NOD molecules
TLR