6 and 8 November, 2006 Chapter 18 Gene Regulation During Development.
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6 and 8 November, 2006 Chapter 18 Gene Regulation During Development
Overview Differences in cell type are fundamentally differences in gene expression. These expression differences are often monitored using microarray hybridization. Differential gene expression is initiated by asymmetrical mRNA distribution, cell- cell contact, or by diffusible signals. Gradients of signaling molecules can give location information to cells. Asymmetrically distributed mRNAs use the cytoskeleton for localization. Drosophila embryogenesis is a well-understood system of animal development. A morphogen gradient controls dorsal-ventral orientation in Drosophila. Asymmetrically distributed mRNAs control anterior-posterior orientation and ultimately segmentation. Segmentation also depends on the interplay of regulators at the control regions of genes. Bioinformatics tools are useful in identifying genes that are developmentally regulated.