1. Lectures on Computational Biology HC Lee Computational Biology Lab Center for Complex Systems & Biophysics National Central University EFSS II National DongHua University Hualien, 2002 July 1-5

2. What is Computational Biology? The use of computational techniques to model biological systems at various levels of complexity - atomic, metabolic, cellular and pathologic.

3. Central dogma for molecular biology DNA RNA Protein

4. Yeast alanyl transfer RNA DNA

5. Standard Genetic Code

6. Amino acid codes Name, 3-letter and single-letter codes Aspartic Acid Asp D Glutamic Acid Glu E Phenylanine Phe F Glycine Gly G Alanine Ala A Cystine Cys C Histidine His H Isoleucine Ile I Lysine Lys K LeucineLeu L Methionine Met M Asparagine Asn N Proline ProP GlutamineGln Q Arginine Arg R SerineSerS Threonine Thr T Valine Val V Tryptophan Trp W Tyrosine Tyr Y

7. A protein cartoon Sperm whale myoglobin (1MBN)

8. The Protein Folding Problem

9. Central Paradigm Central paradigm for Bioinformatics

10. Lecture 1 Sequence Alignment

11. Lecture 2 Hidden Markov Model

12. Lecture 3 Molecular Evolution and Phylogeny

13. Lecture 4 Microarray & Analysis