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Lectures on Computational Biology HC Lee Computational Biology Lab Center for Complex Systems & Biophysics National Central University EFSS II National DongHua University Hualien, 2002 July 1-5
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What is Computational Biology? The use of computational techniques to model biological systems at various levels of complexity - atomic, metabolic, cellular and pathologic.
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Central dogma for molecular biology DNA RNA Protein
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Yeast alanyl transfer RNA DNA
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Standard Genetic Code
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Amino acid codes Name, 3-letter and single-letter codes Aspartic Acid Asp D Glutamic Acid Glu E Phenylanine Phe F Glycine Gly G Alanine Ala A Cystine Cys C Histidine His H Isoleucine Ile I Lysine Lys K LeucineLeu L Methionine Met M Asparagine Asn N Proline ProP GlutamineGln Q Arginine Arg R SerineSerS Threonine Thr T Valine Val V Tryptophan Trp W Tyrosine Tyr Y
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A protein cartoon Sperm whale myoglobin (1MBN)
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The Protein Folding Problem
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Central Paradigm Central paradigm for Bioinformatics
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Lecture 1 Sequence Alignment
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Lecture 2 Hidden Markov Model
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Lecture 3 Molecular Evolution and Phylogeny
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Lecture 4 Microarray & Analysis
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