1. Hormones chemical substances produced in small quantities in one part of an organism and then transported to another part of an organism where they bring about a physiological response

2. Hormones in Animals secreted by –specialized nerve cells called neurosecretory cells neurons that receive signals from other neurons and respond by releasing hormones –specialized cells called endocrine cells usually organized into an endocrine gland

3. Glands Secretory organs Endocrine glands –Produce hormones and secrete them into body fluids –Are ductless Exocrine glands –Produce variety of substance –Convey them directly to the target via ducts

5. Interaction of Nervous System and Endocrine System often cooperate and interact to maintain homeostasis of the individual some endocrine glands are controlled by the nervous system –Hypothalamus –pituitary gland (master gland) Many tropic hormones that stimulate growth in their target organs

7. Nervous Endocrine System System More structurally complexless complex Network of neurons branching organized into glands throughout the body Neurons conduct electrical signalshormones released into directly to the target the blood and travel throughout the body but only affect target Very fast conduction of signalmay take minutes to hours to days for response to occur

8. Nervous Systems Three Main Functions: 1. Sensory Input 2. Integration 3. Motor Output

9. Two Main Parts of Nervous Systems Central nervous system (CNS) –brain and spinal cord –integration Peripheral nervous system (PNS) –network of nerves extending into different parts of the body –carries sensory input to the CNS and motor output away from the CNS

10. Two Cell Types in Nervous Systems Neurons –Cells that conduct the nerve impulses Supporting Cells - Neuroglia

11. Neuron

12. Supporting Cells - Neuroglia provide neurons with nutrients, remove wastes Two important types in vertebrates –Oligodendrocytes – myelin sheath in CNS –Schwann cells -myelin sheath in PNS

13. Myelin Sheath Formation

15. Conduction of the Nerve Impulse Membrane Potential –Voltage measured across a membrane due to differences in electrical charge –Inside of cell is negative wrt outside Resting potential of neuron = -70 mV

16. Figure 48.6 Measuring membrane potentials

18. 1. Carrier in membrane binds intracellular sodium. 2. ATP phosphorylates protein with bound sodium. 3. Phosphorylation causes conformational change in protein, reducing its affinity for Na +. The Na + then diffuses out. 4. This conformation has higher affinity for K +. Extracellular K + binds to exposed sites. 5. Binding of potassium causes dephosphorylation of protein. Extracellular Intracellular ATP ADP PiPi P + K+K+ Na + 6. Dephosphorylation of protein triggers change to original conformation, with low affinity for K +. K + diffuses into the cell, and the cycle repeats. PiPi PiPi PiPi Sodium-Potassium Pump

19. Excitable Cells Neurons & muscle cells Have gated ion channels that allow cell to change its membrane potential in response to stimuli

21. Gated Ion Channels Some stimuli open K+ channels –K+ leaves cell –Membrane potential more negative –hyperpolarization Some stimuli open Na+ channels –Na+ enters cell –Membrane potential less negative –depolarization

22. Gated Ion Channels Strength of stimuli determines how many ion channels open = graded response

23. Nerve Impulse Transmission

24. Action Potentials Occur once a threshold of depolarization is reached –-50 to –55 mV All or none response (not graded) –Magnitude of action potential is independent of strength of depolarizing stimuli Hyperpolarization makes them less likely

25. Membrane potential (mV) 2. Rising Phase Stimulus causes above threshold voltage +50 0 12 3 –70 Time (ms) 1. Resting Phase Equilibrium between diffusion of K + out of cell and voltage pulling K + into cell Voltage-gated potassium channel Potassium channel Voltage-gated sodium channel Potassium channel gate closes Sodium channel activation gate closes. Inactivation gate opens. Sodium channel activation gate opens 3. Top curve Maximum voltage reached Potassium gate opens 4. Falling Phase Potassium gate open Undershoot occurs as excess potassium diffuses out before potassium channel closes Equilibrium restored Na + channel inactivation gate closes K+K+ Na + Na + channel inactivation gate closed

26. Refractory Period During undershoot the membrane is less likely to depolarize Keeps the action potential moving in one direction

27. Propagation of Action Potential Action potential are very localized events DO NOT travel down membrane Are generated anew in a sequence along the neuron

28. Cell membrane Cytoplasm resting repolarized depolarized + + + + + + + + + – – – – – – – – – + + + + + + + + + – – – – – – – – – – – + + + + + + + + + – – – – – – – + + + + + + + – – – – – – – – – + + + + – – + + + + + – – + + – – – – – + + + + + – – + + – – – – – + + – – + + + + – – – + + – – – – + + + – – + + – – – + + + + – – + + + – – – – + + + + + + + – – – – – – – – – + + – – + + + + + + + + + – – – – – – – Na + K+K+ K+K+ K+K+ K+K+ K+K+ K+K+

29. Saltatory Conduction

30. Transfer of Nerve Impulse to Next Cell Synapse –the gap between the synaptic terminals of an axon and a target cell

31. Transfer of Nerve Impulse to Next Cell Electrical synapses –Gap junctions allow ion currents to continue Chemical synapses –More common –Electrical impulses must be changed to a chemical signal that crosses the synapse

32. Synapses

33. Neurotransmitters

34. Human Cerebrum Cerebellum Spinal cord Cervical nerves Thoracic nerves Lumbar nerves Femoral nerve Sciatic nerve Tibial nerve Sacral nerves Nerve net Nerve cords Associative neurons Brain Giant axon Mollusk Echinoderm Central nervous system Peripheral nerves Brain Ventral nerve cords Radial nerve Nerve ribs Cnidarian Flatworm Earthworm Arthropod Diversity of Nervous Systems

35. PNS CNS Brain and Spinal Cord Sympathetic nervous system "fight or flight" Parasympathetic nervous system "rest and repose" Somatic nervous system (voluntary) Sensory neurons registering external stimuli Autonomic nervous system (involuntary) Sensory Pathways Motor Pathways central nervous system (CNS) peripheral nervous system (PNS) Sensory neurons registering external stimuli

36. Constrict Secrete saliva Dilate Stop secretion Dilate bronchioles Speed up heartbeat Increase secretion Empty colon Increase motility Empty bladder Slow down heartbeat Constrict bronchioles Sympathetic ganglion chain Stomach Secrete adrenaline Decrease secretion Decrease motility Retain colon contents Delay emptying Adrenal gland Bladder Small intestine Large intestine Spinal cord ParasympatheticSympathetic

38. Vertebrate Central Nervous System Spinal Cord –Receives info from skin & muscles –Sends out motor commands for movement & response Brain –More complex integration –Homeostasis, perception, movement, emotion, learning

39. Vertebrate Central Nervous System White matter –Internal part of brain & external part of spinal cord –Myelinated axons Gray matter –Cell bodies of neurons

40. Figure 48.16x Spinal cord

41. Vertebrate Central Nervous System Cerebrospinal Fluid –Fills central canal of spinal cord and ventricles of brain –Shock absorption

42. Functions of Spinal Cord Carrying information to and from the brain Integration of simple responses –Reflexes Unconscious programmed response to stimuli

43. Quadriceps muscle (effector) Spinal cord Dorsal root ganglion Gray matter White matter Monosynaptic synapse Sensory neuro Nerve fiber Stretch receptor (muscle spindle) Skeletal muscle Stimulus Response Motor neuron

44. Evolution of Vertebrate Brain Evolved from a set of three bulges at the anterior end of spinal cord –Forebrain (cerebrum) –Midbrain (optic lobe) –Hindbrain (cerebellum & medulla oblongata) Regions have been further subdivided structurally and functionally

45. Vertebrate Brains Olfactory bulb CerebrumThalamus Optic tectum Cerebellum Spinal cord Medulla oblongata Pituitary Hypothalamus Optic chiasm Forebrain (Prosencephalon) Midbrain (Mesencephalon) Hindbrain (Rhombencephalon)

46. Vertebrate Brains The relative sizes of different brain regions have changed as vertebrates evolved -Forebrain became the dominant feature