Presentation on theme: "Gene annotation: Laccases and multicopper oxidases"— Presentation transcript:
1 Gene annotation: Laccases and multicopper oxidases 4th Workshop of the Laccaria Genome ConsortiumGeorg-August-Universität, Göttingen - November 16-17, 2006P.J. Hoegger1, S. Kilaru1, P.E. Courty2, F. Martin2, U. Kües11Georg-August-University Göttingen, Germany2INRA Nancy, France
2 Multi-copper oxidase family main members: - laccases- fungi- plants- insects- bacteria- ascorbate oxidases- ferroxidases- ceruloplasmins- mammals
3 Laccase function and application Biological functions: - lignin degradation- lignification- pigment synthesis- fruiting body formation- melanin polymerization- detoxification- cuticle sclerotization- soil litter polymer degrad.Applications: - bleaching processes- bioremediation- composite wood production
4 1 type-1 Cu 1 type-2 Cu 2 type-3 Cu Trametes versicolorlaccase Lcc1Piontek et al. 2002, JBC 277,
5 Fungal laccase structure Signal sequenceSubstrate binding loopsIIIIIIIVHHHHHHHHCHHL1L2L3L4signature sequences, including copper ligands
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