1. WG 3: Impact assessment ► 9 members – good discussions ► Xenobiotics in the Urban Water Cycle ?? COST 636 Xenobiotics in the Urban Water Cycle – Kick-off meeting DTU 7-9 Sept. 2005 37

2. WG 3 – Impacts and assessment area ► Impacts  adverse effects on ecosystems and humans induced by xenobiotics ► Assessment area – urban water  wastewater ► municipal ► industrial? ► hospital?  stormwater  surface water  groundwater  drinking water  ”recreational” water ► bathing water  recycling water ► ”who” is impacted? who is hit (target/non-target) COST 636 Xenobiotics in the Urban Water Cycle – Kick-off meeting DTU 7-9 Sept. 2005 37

3. Xenobiotics? Man-made chemicals or materials not produced in nature and not normally considered a constituent component of a specified biological system. The term is usually applied to manufactured chemicals. (Van Leeuwen & Hermens, 1995) COST 636 Xenobiotics in the Urban Water Cycle – Kick-off meeting DTU 7-9 Sept. 2005 37

4. WG 3 – xenobiotics ► Xenobiotics covered by WG3  man-made chemicals in ”forms” or amounts not normally found in nature ► xenobiotic organic compounds ► heavy metals  strong urban source ► input FROM urban areas  WG1 ► background concentrations.... ► Chemicals  grouping/tracers (use, chemical structure, distribution)  matrix  WG 1 (source)  priority pollutants (e.g. WFD) COST 636 Xenobiotics in the Urban Water Cycle – Kick-off meeting DTU 7-9 Sept. 2005 37

5. WFD in WG 3 ► the legal frame  but not scientific ► retrospective... not proactive ► toolbox-development ► stakeholders as driving force ► groundwater – surface water interaction ► ecotoxicological status vs ecological status ► threshold limit values across Europe COST 636 Xenobiotics in the Urban Water Cycle – Kick-off meeting DTU 7-9 Sept. 2005 WFD WG3 37

6. Long-term objective for WG3 ► Conceptual framework for impact assessment for xenobitics in the urban water cycle ► Biotests as analytical tool ► Are we measuring the right thing?  Common research project...  Marie Curie proposal... COST 636 Xenobiotics in the Urban Water Cycle – Kick-off meeting DTU 7-9 Sept. 2005 37

7. Action plan 2006-2008 ► Plan for 2006  Meeting in March/April 2006 – in Luxembourg (??)  WG3 in Freiburg in Oct 2006 (only WG3!!) ► Activities 2007 & 2008  Themes – 2 meeting/yr  Conceptual framework – building blocks ► Activities between meetings  Before 1 st meeting: Background papers ► what’s the status of applying biotests for impact assessment around Europe (and North America) (draft by Zita Vosyliené) ► state-of-the-art for complex mixture assessment (Sureyya Meric) ► impact assessment relation to WFD (Verena Höckele) ► overview of the ”impact assessment” expertises within the group – 3-4 lines of expertises, key publication, test methods available, ongoing project (Anders Baun provide outline, collects input, write intro)  Identification opportunities for exchange of human resources  Identification of common topics for training courses COST 636 Xenobiotics in the Urban Water Cycle – Kick-off meeting DTU 7-9 Sept. 2005 37

8. Themes in 2006 1 st meeting Impact thresholds in the environment & humans  methods from molecular level  whole organisms  ecosystem  which methods exist? state-of-the-art  what do they tell us?  do we really use the appropriate methods to evaluate the impacts we are interested in  do we have the methods for this?  do we have the relevant expertises represented in WG3  going beyond what we take for granted... ways of evaluating results (e.g. statistical significance)  link to WFD? COST 636 Xenobiotics in the Urban Water Cycle – Kick-off meeting DTU 7-9 Sept. 2005 37

9. Themes in 2006 2 nd meeting Complex composition – how is dealt with in different countries?  Impact of the whole sample is the only relevant thing...!?  WET – whole effluent testing – not only xenobiotics give rise to adverse effects  Chem. anal. vs effects  TIE – Toxicity Identification Evaluation ► Groupwise fractionation techiques ► Source tracking – gaining knowledge about composition  Treatment efficiency – tox before and after cleaning  WG2  Concentrations – continous discharge vs. intermittent discharges COST 636 Xenobiotics in the Urban Water Cycle – Kick-off meeting DTU 7-9 Sept. 2005 37

10. 2007-2008 WG 3 – list of ”discussion words” ► Bioavailability – exposure concentration  chemical vs biological methods ► By-products, degradation products, metabolites ► Existing bioassays for monitoring discharges – WFD ► Human toxicology – drinking water issues ► Water vs sediments ► Risk management ► Urban area – defined by space or activities? ► Test batteries ► Ring testing – biological and chemical... not in WG3 ► Sinks – long-term vs. short-term storage WG1  dynamics ► Training courses/schools QA/QC ► Particles ► Scales  average human vs. ecosystem (”½ pregnant woman”)  dilution  does the tests/chem analyses make sense? ► site specific vs. generic ► spatial ► temporal ► extrapolation ► uncertainty ► How to select chemicals?  task force with members from WG1-4  largest possible list?  national lists of PP ► How to choose methods? COST 636 Xenobiotics in the Urban Water Cycle – Kick-off meeting DTU 7-9 Sept. 2005 37