1. serum Se concentrations of Americans NHANES III data (1988-94) n= 16,749 reduced cancer risk adequate 1.5 mcg/kg/d 96 mcg (w), 120 mcg (m)

2. Is Se safe? signs first sign is “garlic breath” other are dermatologic (pathological nails, brittle hair, skin rash) chronic dietary intakes >1000 ug/day signs are reversible on reduction of Se exposure NOAEL (EPA) blood level: 1000 ng Se/ml intake: 853 mcg Se/d (adult, male) (5 mcg Se/kg BW/d) these levels are cautious; much greater than normally observed findings from NPC trial (285-300 mcg Se/d) no dermatologic signs no abnormal serum enzymes a few complaints of mild gastrointestinal upset

3. endpoints for various Se doses

4. IOM 2000: UL = 400 mcg/d

5. IOM UL 400 mcg/d practical UL 400-125 = 275 mcg/g

6. UL cancer protection half-dose practical UL cancer protection RDA

7. practical UL cancer protection direct use health blending RDA

8. UL RDA practical UL cancer protection cancer protection half-dose meeting the RDA

9. UL RDA practical UL cancer protection cancer protection half-dose providing selenium

10. UL RDA practical UL cancer protection cancer protection half-dose providing selenium for blending

11. chemoprevention/safety information on sources of Se safetyefficacysafetyefficacy +++++ Se-yeast + Se-methylselenocysteine ++ selenomethionine ++ Na 2 SeO 4 ++++++++++ Na 2 SeO 3 human clinical trials animal model studies source