1. 1 ANATOMY AND TIME Barry Smith

2. 2 SNAP AND SPAN

3. 3 To understand relations between universals Reference to times and instances are important A derives from B concept A derives from concept B

4. 4 Official OBO definition term: derived_from definition: Any kind of temporal relationship, such as derived_from, translated_from

5. 5 Better Definition A derives from B for any instance x of A there is some instance y of B such that x exists earlier than y and

6. 6 What is an anatomy standardization for? Anatomy: across species (human, mouse) (SAEL) across time (development, growth, aging) from generic (normal + abnormal) to instance-based) Tied to: genomic clinical (disease pathways)

7. 7 FMA = (AT, ASA, ATA, Mk) AT = Anatomy Taxonomy ASA = Anatomical Structural Abstraction Mk = Metaknowledge

8. 8 FMA = (AT, ASA, ATA, Mk) ATA, or Anatomical Transformation Abstraction describes the time-dependent morphological transformations of the concepts represented in the taxonomy during the human life cycle, which includes prenatal development, postnatal growth and aging;

9. 9 FMA = (AT, ASA, ATA, Mk) ATA, or Anatomical Transformation Abstraction describes the time-dependent morphological transformations of the concepts represented in the taxonomy during the human life cycle, which includes prenatal development, postnatal growth and aging;

10. 10 single-cell zygote multi-cell zygote morula early blastocyst gastrula new born infant adolescent young adult

11. 11 A sequence of SNAP ontologies

12. 12 together with SPAN ontologies for processes/transformations physiological processes development processes aging processes growth processes SNAP

13. 13 each of these at a plurality of levels of granularity physiological processes SNAP molecular subcellular cellular

14. 14 SNAP time

15. 15 time canonical vs. instantiated

16. 16 time undeformed  deformed

17. 17 time undeformed  deformed these are not instances

18. 18 time undeformed  deformed WINDOWS ON REALITY

19. 19 time undeformed  deformed SYMBIOSIS OF KNOWLEDGE ABOUT UNIVERSALS AND INSTANCES

20. 20 time undeformed  deformed

21. 21 time undeformed  deformed human chimpanzee mouse fly yeast bacteria

22. 22 time undeformed  deformed human chimpanzee mouse fly yeast bacteria

23. 23 A Proposed Standardization relations

24. 24 A Proposed Standardization OBO Relations Ontology

25. 25 A Proposed Standardization OBO Relations Ontology is part of is member of (a collection) is location of -- is contained in … is connected to is later than – is simultaneous with … is bearer of is function of causes is functioning of