1. Voltaren and Cataflam Voltaren and Cataflam Tehran, Iran Dr. Narges Alavi, Brand Manager

2. Agenda | Presentation Title | Presenter Name | Date | Subject | Business Use Only2  Differentiation between Voltaren & Cataflam  Indications ( Acute & Chronic Pain)  Voltaren Messages  Cataflam Messages  Dosage forms  Prices

4. Class -Diclofenac Sodium, a derivative of phenyl acetic acid.

5. Properties | Presentation Title | Presenter Name | Date | Subject | Business Use Only5  Inhibits prostaglandin (PG) biosynthesis. PGs largely contribute to causation of inflammation, pain and fever.  A non-steroidal compound with pronounced anti- rheumatic, anti-inflammatory, analgesic and antipyretic properties.

6. Voltaren In Rheumatic Disease | Presentation Title | Presenter Name | Date | Subject | Business Use Only6 Gives marked relief from: - Pain at rest.- Pain on movement. - Morning stiffness.- Swelling of joints. 2. Provides an improvement of function.

7. Kinetics of the different dosage forms

8. Voltaren Indications in CHRONIC pain | Presentation Title | Presenter Name | Date | Subject | Business Use Only8  Inflammatory and degenerative forms of rheumatism.  Rheumatoid arthritis.  Osteoarthritis & Spondylarthritis.  Juvenile Rheumatoid Arthritis.  Ankylosing Spondylitis.

9. Voltaren Dosage | Presentation Title | Presenter Name | Date | Subject | Business Use Only9  Ideal daily dose: 150 mg.  Long term Therapy: 75-100 mg daily  In 2 - 3 fractional doses or once daily  Starting dose: 100-150 mg daily (in milder cases: 75-100 mg daily)

10. Voltaren forms in Iran Voltaren Retard 100mg Voltaren SR 75mg Voltaren EC 50mg

11. 40 years More than billion patients use. In more than 140 countries

12. Voltaren Messages | Presentation Title | Presenter Name | Date | Subject | Business Use Only12  Demonstrated in over 3900 trials which make it the standard reference drug for testing new NSAIDs.  Continues to demonstrate a favourable safety profile  Wide range of forms & strengths.  The original one from the house of NSAIDs.  Concentrations in synovial fluid are higher than concentrations in the plasma & remain higher for up to 12 hrs.  Has a strong analgesic effect.

13. 13 CATAFLAM

14. Cataflam Class | Presentation Title | Presenter Name | Date | Subject | Business Use Only14 It belongs to the NSAID’s class. “diclofenac potassium, a derivative of phenylacetic acid”.

15. Cataflam Indications In ACUTE Pain | Presentation Title | Presenter Name | Date | Subject | Business Use Only15  CATAFLAM will be positioned as the FAST RELIEF for Non-Rheumatic Pain indication 1. URTI 2. Sprain & Strain. 3. Dental Pain 4. Dysmenorrhea

16. 16 Cataflam 50 | Business Use Only- Mean Peak Plasma After 3.8 µmol/L reached in 20-60 Min AUCHalf That of Injection Protein Binding99.7% (Chiefly to Albumin :99.4%) T 1/2 1-2 h Site Of Inflammation8-12 h Excretion60% Urine 40% Faeces CATAFLAM Pharmacokinetics

17. Rapid Pain Relief observed within 10 minutes with Cataflam 17

18. Cataflam Dosage | Presentation Title | Presenter Name | Date | Subject | Business Use Only18 CATAFLAM 50 MG  2- 3 Tabs daily ( 100 – 150 mg) ( over 14 yrs ).  Before meals.  Forms: 20 tab

19. Cataflam for ACUTE PAIN & RAPID Pain Relief 19

20. Voltaren & Cataflam Price list 20

21. Thank you