1. Medical Technology and Life Sciences: Research, Investment and Industry Collaboration – Turning a Vision into Reality Open Innovation, Metaconnecting and Investing for Impact - “A Brave New World” Professor Alan Barrell Centre for Entrepreneurial Learning University of Cambridge Advisory Board MedCity London Chairman Eagle Genomics Ltd Chairman Bactest Ltd - SME of the Year 2014

2. Aiming to become the global leading hub for life sciences in the western world within 30 years. MedCity will act as “the front door” to one of the world’s leading collections of Life Sciences talent, research and expertise, enabling this resource to grow further and expand the economic benefits of these activities. MedCity’s objective is to improve the attractiveness of London and the Greater South East (GSE) as a destination for life science research, development and commercialisation. To enable ALL appropriate centres of bioscience excellence to connect, collaborate and co-ordinate – and to optimise local and inward investment

3. A key programme for the Mayor and London Assembly and Greater London Authority Leveraging an unparalled pool of academic and business talent in the life science sector

4. The Cambridge Phenomenon 50 Years of Innovation and Enterprise My international activities are based in Cambridge, The University and The Cambridge Cluster and Phenomenon Witnessed the evolution of one successful Entrepreneurial Ecosystem. Excited to be joined up through MedCity, Tech City with others in London Oxford the South East Natonwide and beyond. Witnessed the evolution of one successful Entrepreneurial Ecosystem. Excited to be joined up through MedCity, Tech City with others in London Oxford the South East Natonwide and beyond. Working with entrepreneurs across borders and boundaries – collaboration, synergy and symbiosis beat just competing with each other.

5. London and the South East – Super Strong Life Science and Tech Clusters  Leading Research Universities – partnering with industry – “spinning out and starting up”  Value of the NHS as an integrated system – test bed for research and population studies  Wave of investment – new Institutes – eg Crick and Imperial West – promoting collaboration and innovation  Huge appetite for cross-disciplinary work – Science, Engineering, Life Sciences, IT/Computer Science  Growing SME network  Strong Govt. support and investment community favoured by excellent tax incentives  Developing Alternative Finance Industry boosting sources of funds for research and start ups

6. “Brain Circulation and Knowledge Sharing Across Borders and Functions” “Open Innovation Thinking” and Action to match Extending the mindset and “metaconnecting” And Open Innovation brought Culture Change to Cambridge the University and the Community and other Communities…. Starting with MINDSET – Belief in “A World Without Borders”

7. Diverse Global Prospects are enhanced and multiplied by being connected in London and other Centres in UK  World Leadership in key areas of Science, Technology and Research  Between us connected with numerous leading centres in key areas of development – in all science and technology sectors  Strong links with Americas and Asia – as well as Europe  Top UK Universities attracting Top graduates and researchers  Still a very attractive market for FDI – should be aiming to attract more  The NHS remains a brand of high repute worldwide – a brand to build businesses upon We must encourage the mindset of more connecting at all levels – and of outreach, especially in the next generation

8. Lets take a step back…..Learning from History and Achievement - What do all great change makers have in common? “IMAGINATION” – said Einstein – “and it is more important than knowledge. Knowledge is limited – Imagination encircles the World” We have an abundance of Imagination between us.

9. “You look at things and ask - why? but I dream of things that never were and ask…. George Bernard Shaw why not?” Then there is Entrepreneurship…. All the great Leaders and change agents who have “made a difference” have been “Why Not” people. Entrepreneurship is a mindset. A mindset being nurtured in our life science centres here.

10. Getting to Specifics - Today and The Future - Converging Revolutions Three Pervasive Technology Platforms BIO TECH Pharmaceuticals Diagnostics Research/Info Tools Industrial Genomics Bioinformatics Proteomics INFO TECH Hardware Software Communications NANO TECH Electrical Structural Biomedical Energy & Environment Biosensors Biochips Bioelectronics Microfluidics Nanobiotechnology Drug Delivery Nanodevices Nanosensors Nanoelectronics Open Innovation enables…. Transfer of tacit knowledge Life Sciences and Digital Technology + Entrepreneurial Mindset – changing the world of Healthcare at all levels

11. Proximity of Learning, Research and Practical Application “The Innovation Campus” R&DEducation Applications Where open innovation, symbiosis, synergy, knowledge transfer, and new companies can thrive. Connecting our campuses multiplies capability

12. “Clusters of Creativity for Growth” - Open Innovation is at the heart of the growth of Technology Based Clusters and Hi Tech Regions – where we find Common Characteristics....in centres like London, Cambridge, Oxford “Clusters of Creativity for Growth” - Open Innovation is at the heart of the growth of Technology Based Clusters and Hi Tech Regions – where we find Common Characteristics....in centres like London, Cambridge, Oxford Knowledge Centers Entrepreneurs & Role Models Money Capital Markets Infrastructure Cluster Policy Presence of International Companies Networks Government Quality of Life MindsGlobal Mindset….and Minds without Borders – Global Mindset….and Scale – Size – Populations 0.5 – 1 million common Source – Gibbons – Stanford Univ.2001

13. Importance and Value of Intermingling – crossing boundaries, co-relating and co-creating

14. Product Development Evolution and the Money Supply Chain From Idea to Marketplace The Commercialisation of Research and Ideas Little /no cost R&D POC Grants TSB Some EU Bus. Angels VC “A” Round VC “B” Round “Catapult Centres” & Seed Funds “Catapult Centres” & Seed Funds A developing coherence and integration of processes, skills and ££££. Closer connections and exchanges between Business Angels, Venture Investors and Alternative Finance

15. The Biomedical Industry Pharmaceutical – drugs Biotechnology – drugs, technologies and services Regenerative medicine/stem cells - therapies, technologies and services Medical – devices, diagnostics, equipment, services Digital systems – Telemedicine and E-Health Great strength and diversity – in the South East Connected internationally

16. Key Research and Practice area - Regenerative Medicine Proximity to patientsProximity to patients Access to clinical expertiseAccess to clinical expertise Proximity to clinical facilitiesProximity to clinical facilities South of England Technology Innovation Centres and collaborationSouth of England Technology Innovation Centres and collaboration Investing for long haul R&D and Innovation

17. New Era of Personalised Medicine emerging Drug failures New reimbursement models End of the blockbuster? Patients/Volunteers -Records -Samples Data mining Pathology Imaging Pre-clinical Clinicians Clinical facilities Diagnostics expertise We have strength in depth and international connections in all key fields

18. Medical Devices/Equipment More sophisticatedMore sophisticated Closer relationships between developer and end-userCloser relationships between developer and end-user Co-developmentCo-development Embedded labs in hospitalsEmbedded labs in hospitals Beta- testingBeta- testing Market pull –v- technology pushMarket pull –v- technology push International Companies and Research Excellence

19. Aftercare Call Centre CCS/PCS District Council Home equipment Social Care GP Services Community Health Services Hospital Discharge GP receptionist The Service County Council The Future – for all Nations - Supported Self-Care Imperative of driving Digital Health

20. The Internet + Innovation and Entrepreneurship = Seismic CHANGE and PROGRESS Supports Technology Convergence and Innovative Alternative Finance – where London and UK lead Europe and the World Tim Berners Lee

21. Connected Health Life-tech and Health Smart Mobility Smart Materials Food and Technology High Tech Systems Dehydration or lack of food Your clothes Play the Smoking App Converging, Connecting and Collaborating Enabling Future Positive Directions….

22. Looking at some real specifics…. New initiatives – new “ABC” – in Healthcare – cross disciplinary collaboration in practice….

23. Next Generation – better connected to optimise life science development opportunities.

24. Bringing Ultrasound applications together Ultrasound TreatmentUltrasound Imaging UltruniqVision: “Restoring the quality of life for Alzheimer’s patients everywhere” Next generation connecting across the South East and the World

25. Partnership with industry on Life Science start ups and acceleration - Cambridge, Oxford, London Universities – new business generation within partnership with Industry – and Astra Zeneca support and incubation……… Accelerate Cambridge

26. Many other examples of groundbreaking developments ……just two more highlighted here which impact cancer diagnosis and treatment…. OWLSTONE NANOTECH Developing a “breathalyser” that can detect chemicals in the breath that indicate lung cancer – enabling early diagnosis. LIGHTPOINT MEDICAL Developing imaging technology that allows the accurtae real-time detection of cancerous tissues during surgery, described as “the holy grail” of cancer treatment.

27. Expansion on the grand scale at “Imperial West”

28. The Francis Crick Institute – Leading Edge Medical Research World class teams connected with other leaders in other UK and International Centres – breaking new ground in Cancer Research and other key areas

29. Research Leadership at UCL too….

30. UCL, Imperial College, Kings London, Cambridge and Oxford “Better Together” Convergence, Collaboration and Co-ordination

31. Digital Healthcare and Medical Education – Leading Edge The Future Here and Now – at Imperial College

32. New Jobs / New Markets DUTCH GAME GARDEN BREDA Creative Skills STEM Skills Business Skills DUTCH GAME GARDEN BREDA Creative Skills STEM Skills Business Skills REACTOR Creative Skills STEM Skills Business Skills REACTOR Creative Skills STEM Skills Business Skills CURSOR Creative Skills STEM Skills Business Skills CURSOR Creative Skills STEM Skills Business Skills SE Asia Germany, N Europe Education > Skills > Accelerators Production Teams, Mentorship, Entrepreneurship Competitions, Festivals, Contracts Start-Ups < Skills < Education Baltic Region, Russia Will include Digital Healthcare A new Digital Incubator – South of England JV with European Partners – at Anglia Ruskin University Will embrace Digital Healthcare and is one of a number

33. Joined Up Systems and Societies achieve more Joined Up Systems and Societies achieve more Clusters of Creativity can become SUPERCLUSTERS

34. MedCity – Aiming to bring Leadership in Life Sciences to Great Britain

35. In Pursuit of Excellence ! – Final Thoughts “ Excellence can be achieved, if we: Care more than others think is wise, Risk more than others think is safe, Dream more than others think is practical, Expect more than others think is possible.” Deborah Johnson-Ross Deborah Johnson-Ross Setting the Highest Standards PEOPLE make the difference - ours are amongst the best!

36. Thank You for Listening alan@alanbarrell.com www.alanbarrell.com